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    Curriculum Vitae

    Name: Huaxi Xu, Ph.D.

     Professor and Acting Director,

    Neurodegenerative Disease Program

     Center for Neuroscience, Stem Cell and Aging Research

     BURNHAM INSTITUTE for MEDICAL RESEARCH

     10901 N. Torrey Pines Road

     La Jolla, California 92037.

     Professor and Dean/Director

     Institute for Biomedical Research

     Xiamen University, China.

    Home Address: 7072 Santa Fe Canyon Place,

     San Diego, CA 92129

    Contact information: E-mail: xuh@burnham.org

     858-795-5246 (Office), 858-597-5273 (Fax)

     Citizenship: U.S. citizen

EDUCATION/EXPERIENCE:

    Sept., 1981-June, 1985: Xiamen University, China.

     B.S. in Biochemistry.

Aug., 1987-Jan., 1988: Visiting Scholar.

     Division of Rheumatology.

    University of Connecticut Health Center, Farmington, CT.

Sept., 1988-May, 1993: Ph.D.

    Dept. of Anatomy and Structural Biology.

     Albert Einstein College of Medicine, New York.

     Advisor: Dennis Shields.

    May, 1993-May, 1994: Post-Doctoral Fellow.

     Dept. of Developmental and Molecular Biology,

     Albert Einstein College of Medicine.

     Advisor: Dennis Shields.

June, 1994-June 1998: Post-Doctoral Associate, Research Associate.

     Laboratory of Molecular and Cellular Neuroscience,

     The Rockefeller University, New York, NY.

     Advisor: Paul Greengard.

    Joint Appointment in Dept. of Neurology & Neuroscience,

    Cornell University Medical College, New York, NY.

    Advisor: Sam Gandy.

    July, 1998-June, 2003 Assistant Professor,

     Fisher Center for Research on Alzheimer Disease,

     The Rockefeller University, New York, NY.

    July, 2003-April, 2008 Associate Professor,

    Neurodegenerative Disease Program

    Burnham Institute for Medical Research

    May, 2008- Professor and Acting Director (March 2007 - )

    Neurodegenerative Disease Program

     Burnham Institute for Medical Research

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AWARDS/GRANTS:

     Principal Investigator, NIH R01 (NS046673), 2003-2008, 2008-2013

     Principal Investigator, NIH R01 (AG030197), 2007-2012.

     Principal Investigator, NIH R03 (AG034366), 2009-2011.

     Co-Principal Investigator, NIH R01 (NS054880), 2006-2011.

     Principal Investigator, NIH R01 (AG021173), 2004-2009.

     Alzheimer’s Association, Zenith Fellow Award, 2008-2010.

     American Health Assistance Foundation (AHAF), Alzheimer Disease Research

    Award, 2005-2007, 2008-2011.

     Alzheimer’s Association, Investigator Initiated Research Award, 2003-2007.

     Project Leader, NIH/NIA Program Project Grant (Signal Transduction and

    Alzheimer’s disease) P01-AG09464, 2001-2006.

     Principal Investigator, Research Grant from Functional Genetics, Inc. 2001-2004.

    ($200,000/year).

     Alzheimer’s Association, Investigator Initiated Research Award, 1999-2002.

     Ellison Medical Foundation New Scholars in Aging Award, 1999-2003.

     “The Ruth Salta Junior Investigator Achievement Award”, American Health

    Assistant Foundation. 2003.

     American Health Assistance Foundation (AHAF), Alzheimer Disease Research

    Award, 1999-2001.

     Research Grant Award, American Federation for Aging Research (AFAR), 1996-

    1997.

     Travel Award: the 6th International Conference on Alzheimer Disease and

    Related Disorders. 1998 Amsterdam, the Netherlands.

     Travel Award: the 5th International Conference on Alzheimer Disease and

    Related Disorders. 1996 Osaka, Japan.

     Belfer Postdoctoral Fellowship, 1993-1994, Albert Einstein College of Medicine.

Other Experience and Professional Memberships:

    1996- Member, Society for Neuroscience

    1997- Member, American Society for Cell Biology

    1998-2003 Treasurer, New York Alzheimer Disease Research Society 2001- Visiting/Adjunct Professorship, Tongji Medical College; Tsinghua

    University; Xiamen University; and Xiangya Medical College, China. 2003-2005 Member of the Adjunct Faculty, The Rockefeller University 2004-2008 Member, NIH Study Section (CDIN)

    2005- President, Southern California Alzheimer’s Research Society

    2006- Co-Editor-In-Chief, “Molecular Neurodegeneration”

    2007- Member of Editorial Board of The Open Biology Journal”

    2008- Member of Editorial Board of International Journal of Clinical and

    Experimental Medicine

    Ad Hoc reviewer (grants): NIH/NIA Special Emphasis Panel (SEP) on ApoE receptor program projects (ZIJ-4 J4 1) 2006-2008, NIH ICI Study Section (2006), NIH/NIA SEP

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    (AD drug discovery) review of U01 applications (2006, 2007), NIH SEP BDCN-Y 04M (2008), National Science Foundation (NSF), The NSF of China, The Alzheimer’s

    Association, The Wellcome Trust, the US Department of Veterans Affairs, The Volkswagen Stiftung Foundation, United States-Israel Binational Science Foundation, Alzheimer’s Society of Canada, National Medical Research Council (Singapore), Breast Cancer Campaign of UK, & more;

    Ad Hoc reviewer (journals): Cell, Nature Medicine, Nature Cell Biol., Neuron, Proc. Natl. Acad. Sci., J. Exp. Med., J. Biol. Chem., J. Neurosci., J. Clin. Res., Cell Death and Differentiation, Biochemistry, Mol. Cell Biol., FASEB J., Plos Medicine, Annals of Neurology, Neurology, J. Neurochem., Mol. Cell. Neurosci., Mol. Brain Res. Neurobiology of Diseases, Neurobiology of Aging, J. Neurosci Res., Cell Research, Molecular Genetics and Metabolism, Neurosci Lett, and more.

PUBLICATIONS:

    1. Xu, H., and Shields, D. (1993) Prohormone Processing in the trans-Golgi Network:

    Endoproteolytic Cleavage of Prosomatostatin and Formation of Nascent Secretory

    Vesicles in Permeabilized Cells. J. Cell Biol. 122:1169-1184.

    2. Xu, H., and Shields, D. (1994) Prohormone Processing in Permeabilized Cells:

    Endoproteolytic Cleavage Is Mediated by a Vacuolar ATPase That Generates an

    Acidic pH in the trans-Golgi Network. J. Biol. Chem. 269:22875-22881.

    3. Xu, H., and Shields, D. (1994) Prohormone Processing in Permeabilized Cells:

    Endoproteolytic Cleavage of Prosomatostatin in the trans-Golgi Network.

    Biochimie 76:257-264.

    4. Xu, H., Greengard, P., and Gandy, S. (1995) Regulated Formation of Golgi

    Secretory Vesicles Containing Alzheimer ß-Amyloid Precursor Protein. J. Biol.

    Chem. 270:23243-23245.

    5. Musch, A., Xu, H., Shields, D., and Rodriguez-Boulan, E. (1996). The Constitutive

    Pathway of VSV G Protein to the Cell Surface Is Signal Mediated in Polarized and

    Non-Polarized Cells. J. Cell Biol. 133:543-558.

    6. Xu, H., Sweeney, D., Greengard, P., and Gandy, S. (1996). Metabolism of

    Alzheimer ß-Amyloid Precursor Protein: Regulation by Protein Kinase A in Intact

    Cells and in a Cell-Free System. Proc. Natl. Acad. Sci. USA. 93:4081-4084.

    7. Xu, H., Sweeney, D., Wang, R., Thinakaran, G., Lo, A. C. Y., Sisodia, S., Greengard,

    P., and Gandy, S. (1997) Generation of Alzheimer ß-amyloid Protein in the trans-

    Golgi Network in the Apparent Absence of Vesicle Formation. Proc. Natl. Acad. Sci.

    USA. 94:3748-3752.

    8. Xu, H., Gouras, G. K., Greenfield, J. P., Vincent, B, Naslund, J., Mazzarelli, L,

    Jovanovic, J. N, Seeger, M, Relkin, N. R, Liao, F., Checler, F., Buxbaum, J. D, Chait,

    B. T., Thinakaran, G., Sisodia, S., Wang, R., Greengard, P., and Gandy, S. (1998).

    Estrogen Reduces Neuronal Generation of Alzheimer ß-amyloid Peptides. Nature

    Medicine 4:447-451.

    9. Gouras, G. K., Xu, H., Jovanovic, J., Fried, G., Wang, R., Buxbaum, J., Greengard,

    P., Relkin, N., and Gandy, S. (1998). Identification and regulation of the major ß-

    amyloid species secreted by cultured neurons. J. Neurochem. 71:1920-1925.

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    10. Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia,

    S. S., Greengard, P., and Xu, H. (1999). Endoplasmic Reticulum and trans-Golgi

    Network Generate Distinct Populations of Alzheimer ß-Amyloid Peptides. Proc.

    Natl. Acad. Sci. USA 96:742-747.

    11. Greenfield, J. P., Xu, H., Greengard, P., Gandy, S. and Seeger, M. (1999).

    Generation of the amyloid-β peptide N terminus in Saccharomyces cerevisiae

    expressing human Alzheimer's amyloid-β precursor protein. J. Biol. Chem.

    274:33843-33846.

    12. Greenfield, J. P., Gross, R. S., Gouras, G. K., and Xu, H. (2000). Cellular and

    Molecular Basis of ß-Amyloid Precursor Protein Metabolism. Frontiers in

    Bioscience. 5:d72-83.

    13. Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Greenfield, J. P.,

    Haroutunian, V., Buxbaumn, J. D., Xu, H., Greengard, P. and Relkin, N. R. (2000)

    Intraneuronal Aβ42 Accumulation in Human Brain. Am. J. Path. 156:15-20.

    14. Gouras, G. K.*, Xu, H.*, Gross, R., Greenfield, J. P., Hai, B., Wang, R., and

    Greengard, P. (2000) Testosterone Reduces Neuronal Secretion of Alzheimer ß-

    amyloid Peptides. Proc. Natl. Acad. Sci. USA 97:1202-1205. (*, equal contribution).

    15. Gasparini, L., Gouras, G. K., Gross R. S. Beal, M. F., Wang, R., Greengard, P., and

    Xu, H. (2001) Stimulation of beta-amyloid precursor protein trafficking by insulin

    reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase

    signaling. J. Neurosci. 21:2561-2570.

    16. Yan, R., Han, P., Miao, H., Greengard, P., and Xu, H. (2001) The transmembrane

    domain of the Alzheimer’s β-secretase (BACE1) determines its late Golgi

    localization and access to βAPP substrate. J. Biol. Chem. 276:36788-36796.

    17. Yu, C.*, Kim, S. H.*, Ikeuchi, T.*, Xu, H.*, Gasparini, L., Wang, R., and Sisodia, S.

    S. (2001) Characterization of a Presenilin-Mediated “CTF”: Evidence for Distinct

    mechanisms Involved in “β-secretase” processing of the APP and Notch 1

    transmembrane Domains. J. Biol. Chem. 276(47):43756-43760. (*, equal

    contribution).

    18. Zheng, H*, Xu, H.*, Uljon, S. N., Gross, R., Hardy, K., Gaynor, J., Lafrancois, J.,

    Simpkins, J., Refolo, L. M., Petanceska, S., Wang, H and Duff, K. (2002)

    Modulation of Aβ peptides by estrogen in mouse models. J. Neurochem. 80:191-

    196. (*, equal contribution).

    19. Greenfield, J. P., Leung, L, Cai, D., Kaasik, K., Gross, R., Rodriguez-Boulan, E.,

    Greengard, P. and Xu, H. (2002) Estrogen lowers Alzheimer’s β-amyloid peptide

    generation by stimulating trans-Golgi Network vesicle biogenesis. J. Biol. Chem.

    277:12128-12136.

    20. Gasparini, L., Netzer, W., Greengard, P., and Xu, H. (2002) Does Insulin

    Dysfunction Play a Role in Alzheimer's Disease. Trends in Pharmacological

    Sciences 23(6):288-293.

    21. Leem, J. Y., Vijayan, S., Han, P., Cai, D., Machura, M., Lopes, K.O., Veselits, M.L.,

    Xu, H., and Thinakaran, G. (2002) Presenilin 1 is required for maturation and cell

    surface accumulation of nicastrin. J. Biol. Chem. 277(21):19236-19240.

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22. Lu, Z., Murray, J., Luo, W., Li, H., Xu, H., Backer, J. M., and Chen, Y. G. (2002)

    J. Biol. Chem.

    277(33):29363-29368.

    23. Leem J.Y., Saura C.A., Pietrzik C., Chrstianson, J., Wanamaker, C., King, L.,

    Veselits M.L., Tomita, T., Gasparini, L., Iwatsubo, T., Xu, H., Green, W.N., Koo,

    E.H., and Thinakaran, G. (2002) A role for presenilin 1 in regulating the delivery of

    amyloid precursor protein to the cell surface. Neurobiol. Dis. 11(1):64-82.

    24. Luo, Y., Smith, J. V., Netzer, W. J., Curry, K. J., Buford, J. P., Paramasivam, V.,

    Khan, I., Manceva, S. D., Xu, H., Butko, P. (2002). Inhibition of amyloid-β

    aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc.

    Natl. Acad. Sci. USA 99:12197-12202.

    25. Hakahashi, R.H., Milner, T.A., Li, F., Nam, E.E., Edgar, M.A., Yamaguchi, H., Beal,

    M.F., Xu, H., Greengard, P., and Gouras, G.K. (2002) Intraneuronal Alzheimer

    Abeta42 accumulates in multivesicular bodies and is associated with synaptic

    pathology. Am J Pathol 161:1869-1879.

    26. Dou, F., Netzer, W. J., Tanemura, K., Li, F., Hartl, F.U., Takashima, A., Gouras

    G.K., Greengard, P., and Xu, H. (2003) Chaperones increase association of tau

    protein with microtubules. Proc. Natl. Acad. Sci. USA 100:721-726.

    27. Cai, D. Leem, J.Y., Greenfield, J.P., Wang, P., Wang, R., Lopes, K.O., Kim, S.H.,

    Zheng, H., Greengard, P., Sisodia, S.S., Thinakaran, G., and Xu, H. (2003)

    Presenilin-1 regulates intracellular trafficking and cell surface delivery of APP. J.

    Biol. Chem. 278:3446-3454.

    28. Luo, W., Wang, H., Li, H., Kim, B. S., Shah, S., Lee, H. J., Thinakaran, G., Kim, T.

    W., Yu, G., and Xu, H. (2003) PEN-2 and APH-1 Coordinately Regulate Proteolytic

    Processing of Presenilin 1 in the Early Secretory Compartments. J. Biol. Chem.

    278:7850-7854.

    29. Gasparini, L and Xu, H. (2003) Potential roles of insulin and IGF-1 in Alzheimer's

    disease. Trends in Neurosciences 26(8):404-406.

    30. Dou, F., Netzer, W. J., Takashima, A., and Xu, H. (2003) Heat Shock Proteins

    Reduce Aggregation and Facilitate Degradation of Tau Protein. International

    Congress Series 1790, The Elsevier Science.

    31. Liu, S.J., Zhang, A.H., Li, H.L., Wang, Q., Deng, H.M., Xu, H., and Wang, J.Z.

    (2003) Overactivation of glycogen synthase kinase-3 by inhibition of

    phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau

    and impairment of spatial memory in vivo. J. Neurochem. 87:1333-1344.

    32. Netzer, W.J., Dou, F., Cai, D., Veach, D., Jean, S., Li, Y., Bornmann, W.G., Clarkson,

    B., Xu, H., and Greengard, P. (2003) Gleevec inhibits -amyloid production but not

    Notch cleavage. Proc. Natl. Acad. Sci. USA 100(21):12444-12449.

    33. Gasparini, L., Rusconi, L. Xu, H., del Soldato, P., and Ongini, E., (2004) Modulation

    of beta-amyloid metabolism by nonsteroidal anti-inflammatory drugs in neuronal cell

    cultures. J. Neurochem. 88:337-348.

    34. Wang, H., Luo, W-j., Zhang, Y-w., Li, Y., Thinakaran, G., Greengard, P., and Xu, H.

    (2004) Presenilins and -secretase inhibitors affect intracellular trafficking and cell

    surface localization of the -secretase complex components. J. Biol. Chem.

    279:40560-40566.

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    35. Xia, W. and Xu, H. Editors, Book: Amyloid Precursor Protein: A Practical Approach.

    The CRC Press (2004).

    36. Vetrivel, K.S., Cheng, H., Sakurai, K., Li, T., Nukina, N., Wong, P.C., Xu, H. and

    Thinakaran, G. (2004) Association of -secretase with lipid rafts in post-Golgi and

    endosome membranes. J. Biol. Chem. 279:44945-44954.

    37. Zhang,Y-W., Luo, W-J., Wang, H., Lin, P., Vetrivel, K.S., Liao, F., Li, F., Wong,

    P.C., Farquhar, M.G., Thinakaran, G. and Xu, H. (2005) Nicastrin Is Critical for

    Stability and Trafficking but not Association of Other Presenilin/-secretase

    Components. J. Biol. Chem. 280:17020-17026.

    38 Han, P., Dou, F., Li, F., Zhang, X., Zhang Y-W., Zheng, H., Lipton, S.A., Xu, H.*,

    and Liao*, F. F. (2005) Suppression of CDK5 activation by amyloid precursor

    protein: a novel excitoprotective mechanism involving modulation of tau

    phosphorylation. J. Neurosci. 25:11542-11552. (*, Co-correspondent Authors). 39. Wang, R, Zhang, Y-W., Sun, P., Liu, R., Xia, K., Xia, J.H., Xu, H.*, and Zhang, Z*.

    (2006) Transcriptional regulation of PEN-2, a key component of the -secretase

    complex, by CREB. Mol Cell Biol. 26:1347-1354. (*, Co-correspondent Authors). 40. Cai, D., Netzer W. J., Zhang, M., Lin, Y., Du, G., Frohman, M., Foster, D.A.,

    Sisodia, S.S., Xu, H., Gorelick, F.S., and Greengard, P. (2006) Presenilin-1 (PS1)

    uses phospholipase D1 as a negative regulator of -amyloid formation. Proc. Natl.

    Acad. Sci. 103:1941-1946.

    41. Cai, D., Zhong, M., Wang, R., Netner, W.J., Shields, D., Zheng, H., Sisodia S.S.,

    Foster, D.A., Gorlick, S.F., Xu, H.*, and Greengard, P*. (2006) Phospholipase D1

    corrects impaired APP trafficking and neurite outgrowth in familial Alzheimer’s

    disease-linked presenilin-1 mutant neurons. Proc. Natl. Acad. Sci. 103:1936-1940.

    (*, Co-correspondent Authors).

    42. Zhang, X., Li, F., Bulloj, A., Zhang, Y-W., Tong, G., Zhang, Z., Liao, F.F., and Xu,

    H. (2006) Regulation of tau phosphorylation and aggregation by tumor suppressor

    PTEN. FASEB J. 20:1272-1274.

    43. Wang, R., Zhang, Y-w, Zhang, X., Liu, R., Zhang, X., Hong, S.H., Xia, K., Xia, J.,

    Zhang, Z., and Xu, H. (2006) Transcriptional regulation of APH-1A and increased -

    secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J. 20:1275-

    1277.

    44. Wang, Z-F., Li, H-L., Li, X-C., Zhang, Q., Tian, Q., Wang, Q., Xu, H. and Wang, J-

    Z. (2006) Effects of endogenous β-amyloid overproduction on tau phosphorylation in

    cell cultures. J. Neurochem. 98:1167-1175.

    45. Vetrivel, K.S., Zhang, Y-W., Xu, H., and Thinakaran, G. (2006) Pathological and

    physiological functions of Presenilins. Mol Neurodegeneration. 1:4. 46 Zhang, X., Li, F., Zhang, Y-W., Tong, G., Zhang, Z., Liao, F.F., and Xu, H. (2006)

    Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase

    activity of PTEN increases aggregation of an FTDP-17 mutant Tau. Mol.

    Neurodegeneration. 1:7.

    47. He, G, Qing, H, Cai, F, Kwok, C, Xu, H, Yu, G, Bernstein, A, and Song, W. (2006)

    Ubiquitin-proteasome pathway mediates degradation of APH-1. J. Neurochem.

    99:1403-1412.

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    48. Xu, H.*, Wang, R., Zhang, Y-W., Zhang, X. (2006) Estrogen, beta-amyloid

    etabolism/trafficking, and Alzheimer's disease. Ann N Y Acad Sci. 1089:324-342. 49. Lin, P., Li, F., Huang, H., Zhang, Y-w., Tong, G.G., Farquhar, M.G., Xu, H. (2007)

    Calnuc binds to Alzheimer’s β-amyloid precursor protein and affects its biogenesis.

    J. Neurochem. 100:1505-1514.

    50. Zhang, Y-w., and Xu, H. (2007) Molecular and Cellular Mechanisms for

    Alzheimer's Disease: Understanding APP Metabolism. Current Molecular Medicine.

    7:687-696.

    51. Li, H.L., Wang, H.H., Liu, S., Deng, Y.Q., Zhang, Y.J., Tian, Q., Wang, X.C., Chen,

    X.Q., Yang, Y., Zhang, J.Y., Wang, Q., Xu, H., Liao, F.F., and Wang, J.Z. (2007)

    Phosphorylation of tau antagonizes apoptosis by stabilizing -catenin. Proc. Natl.

    Acad. Sci. 104:3591-3596.

    52. Zhang, X., Zhou, K., Wang, R., Cui, J., Lipton, S.A., Liao, F.F., Xu, H.*, and Zhang,

    Y-w.* (2007) Hypoxia inducible factor 1; (HIF-1;)-mediated hypoxia increases

    BACE1 expression and β-amyloid generation. J. Biol. Chem. 282:10873-10880. (*,

    Co-correspondent Authors)

    53. Gandy, S., Zhang, Y-w., Schmidt, S.D., Ikin, A., Nixon, R.A., Liao, F-F., Mathews,

    P.M., Xu, H., and Ehrlich, M.E. (2007) Aberrant Trafficking of the Alzheimer

    Amyloid-β Precursor Protein Through the Neuronal trans-Golgi Network Contributes

    to the Pathogenesis of Mutant Presenilins. J. Neurochem. 102:619-626.

    54. Zhang, Y-w. and Xu, H. (2007) Alteration of β-secretase traffic by the receptor

    tyrosine kinase signaling pathway a new mechanism for regulating Alzheimer’s β-

    amyloid production. (Research Highlight) Cell Res. 17:385-386.

    55. Zhang, Y-w., Wang, R., Liu, Q., Zhang, H., Liao, F-F., and Xu, H. (2007)

    -secretase-dependent processing of APP regulates EGFR expression.

    Proc. Natl. Acad. Sci. 104:10613-10618.

    56. Zhang, H., Wang, R., Liu, R., Hong, S., Xu, H.*, and Zhang Y-w* (2008)

    Presenilins regulate the cellular levels of tumor suppressor PTEN. Neurobiol. Aging

    229(5):653-660. (*, Co-correspondent Authors).

    57. Xiong, H., Callaghan, D., Jones, A., Walker, D.G., Lue, L-F., Beach, T.G., Sue, L.I.,

    Woulfe, J., Xu, H., Stanimirovic, D.B., and Zhang W. (2008) Cholesterol retention

    in Alzheimer’s brain is responsible for high β-and γ-secretase activities and Aβ

    production. Neurobiol. Dis. 29(3):422-437.

    58. Bulloj, A., Leal, M.C., Surace, E.I., Zhang, X., Xu, H., Ledesma, M.D., Castano,

    E.M., and Morelli, L. (2008) Detergent resistant membrane-associated IDE in

    cultured cells and brain tissue: Relevance to Abeta and insulin degradation. Mol.

    Neurodeger. 3 (1):22.

    59. Chen, Y., Zhou, K., Wang, R., Liu, Y., Kwak, Y.D., Ma, T., Thompson, R.C., Zhao,

    Y., Smith, L., Gasparini, L., Luo, Z., Xu, H., and Liao, F.F. (2009) Antidiabetic drug

    metformin (Glucophage?) increases biogenesis of Alzheimer's amyloid peptides via

    upregulating BACE1 transcription. Proc. Natl. Acad. Sci. 106(10):3907-12.

    60. Liu, Y., Zhang, Y-w., Wang, X., Zhang, H., You, X., Liao, F-F. and Xu, H. (2009)

    Intracellular trafficking of Presenilin 1 is regulated by -amyloid precursor protein

    and phospholipase D1. J. Biol. Chem. 284(18):12145-52.

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    61. Liao, F.F., and Xu, H. (2009) Insulin signaling in sporadic Alzheimer's disease.

    Science Signaling, 2(74):pe36.

    62. You, X, Zhang, Y-w, Chen, Y., Huang, X., Xu, R., Cao, X., Chen, J., Liu, Y., Zhang,

    X., and Xu, H. (2009) Retinoid X receptor-; mediates (R)-flurbiprofen’s effect on

    the levels of Alzheimer’s -amyloid. J. Neurochem. 111(1):142-9.

    63. Ma, T., Zhao, Y.B., Kwak, Y-D., Thompson, R., Luo, Z., Xu, H., and Liao, F-F.

    (2009) Statin's excitoprotection is mediated by sAPP and the subsequent attenuation

    of calpain-induced truncation events likely via Rho-ROCK signaling. J. Neurosci.

    29:11226-36.

    64. Zhang, Y-w., Liu, L., Zhang, X., Li, W-B., Chen, Y., Huang, X., Sun, L., Luo, W-j.,

    Netzer, W.J., Threadgill, R., Wiegand, G., Wang, R., Cohen, S.N., Greengard, P.,

    Liao, F-F., Li, L., and Xu, H. (2009) A Functional Mouse Retroposed Gene Rps23r1

    Inhibits Alzheimer’s -Amyloid Generation and Tau Phosphorylation. Neuron.

    64(3):328-340.

    65. Dunys, J., Sevalle, J., Giaimei, E., Pardossi-Piquard, R., Vitek, M.P., Renbaum, P.,

    Levy-Lahad, E., Zhang, Y-w., Xu, H., Checler, F., and Alves da Costal, C. (2009)

    p53-dependent control of PEN-2 promoter transactivation by presenilins. J. Cell. Sci.

    122:4003-4008.

    66. Bulloj, A., Leal, M.C., Xu, H., Castano, E.M., and Morelli, L. (2010) Insulin-

    degrading enzyme sorting in exosomes: a secretory pathway for a key brain A-

    degrading protease. J. Alzheimer’s Dis. 19(1):79-95.

    67. Kwak, Y-D., Wang, B., Pan, W., Xu, H., Jiang, X., and Liao, F-F. (2010) Functional

    interaction of PTEN and the E3 ligase NEDD4-1 during neuronal response to zinc. J.

    Biol. Chem. (in press).

    68. Zhang, Y-w., and Xu, H. (2010) Substrate check for gamma-secretase. Nat. Struct.

    & Mol. Biol. 17(2):140-141.

Patents:

    (1) “Compositions and methods for prevention and treatment of amyloid-beta peptide-

    related disorders”. Inventors: W. J. Netzer, P. Greengard and H. Xu. (Awarded) (2) “Appoptosin and uses thereof for treating neurodegenerative disease and cancer”.

    Inventors: H. Xu and Y. Chen et al. (Awarded).

    (3) FG01 and uses thereof for treating neurodegenerative disease and cancer”. Inventors:

    H. Xu et al. (Pending).

INVITED (OFFICIAL) SEMINARS:

    1996 Department of Pharmacology, University of Florida, Gainesville, FL.

    1997 Department of Cell Biology, University of Alberta, Edmonton, Canada.

    1997 Women’s Cognitive Health--The Role of Estrogen. The Bowman Gray School of

    Medicine of Wake Forest University & Wyeth-Ayerst Laboratories.

    1997 VA Puget Sound Health Care System, University of Washington, Seattle, WA.

     8

    1997 Department of Neurobiology and Anatomy, University of Rochester Medical

    Center, Rochester, NY.

    1997 Department of Physiology, University of Kentucky, Lexington, KY.

    1998 Huddinge Hospital, Karolinska Institute, Stockholm, Sweden.

1998 Merck Research Laboratories, West Point, PA.

1999 Merck Research Laboratories, Merck & Co. Inc., Rahway, NJ.

1999 Department of Pathology, Columbia University, New York, NY.

    2000 Downstate Medical Center, State University of New York at Brooklyn, Brooklyn, NY.

2000 RIKEN Brain Research Institute, Japan.

    2000 Xiamen University, Fujian Medical University and Beijing Medical University, China

    2000 School of Pharmaceutical Sciences, The University of Tokyo, Japan.

    2000 Colloquium on the Biology of Aging, Marine Biological Laboratory Woods Hole, MA.

    2000 Symposium on Cognition Enhancers, Anti-Alzheimer and Neuroprotective Drugs,

    Yale University, New Haven, CT.

    2001 International Conference on Alzheimer and related neurodegenerative diseases,

    Shanghai, China.

    2001 Chair, Young Scientists Symposium “Molecular and Cellular Basis of Alzheimer’s thdisease”. 7 World Congress of Biological Psychiatry, Berlin, Germany.

2001 Nicox Pharmaceutical Inc., Bresso, Italy.

    2001 Colloquium: General Cell Biological Functions of Presenilin and its Relationship

    to Alzheimer’s Disease. Joint Meeting of the International Society for

    Neurochemistry and the American Society for Neurochemistry, Buenos Aires,

    Argentina.

    2001 Tsinghua University and Institute of Genetics, Chinese National Academy of Science.

     rd2002 Workshop Symposium, The American Society for Neurochemistry 33 Annual Meeting,

    West Palm Beach, Florida.

    2002 VA GRECC, Dept. of Medicine, University of Wisconsin at Madison.

2002 Alzheimer Symposium, New York Academy of Sciences.

2002 International Symposium on “Molecular Mechanism and Epochal Therapeutics

    for Ischemic Stroke and Dementia”. Okayama, Japan.

    2002 XVII Reunion Annual De La Sociedad Argentina De Neuroquimica, Cordoba,

    Argentina.

    2002 Department of Immunology and Microbiology, Albert Einstein College of

    Medicine.

    2003 Institute for Biological Sciences, National Research Council, Ottawa, Canada.

     9

    2003 Department of Neuroscience, University of California at San Diego.

2003 Huffington Center on Aging, Baylor Medical College.

    2003 Keynote seminar, Nuove strategie di cure ed assistenziali al servizio del paziente

    demente, Alessandria, Italy.

    2003 Initiative on Aging, University of Illinois at Urbana Champaign.

    2004 Dept of Neurobiology, Pharmacology and Physiology, The University of

     Chicago.

    2004 The 81st Annual Meeting of Physiological Society of Japan, Sapporo, Japan.

2004 Dept. of Neuroscience, Cleveland Clinical Foundation.

    2004 Farber Neuroscience Institute, Thomas Jefferson University

    2004 Mini-Symposium Co-organizer and Speaker, Annual Meeting of Society for

     Neuroscience

     nd2004 Keynote speaker, the 2 International Symposium on the Therapeutic Approaches

    in Alzheimer’s Disease, sponsored by Korean NIH, Seoul, Korea.

    2005 The Ellison Medical Foundation Colloquium, Buck Institute.

2005 Gwangju Institute of Science and Technology, Korea.

     th2005 The 6 Biomedical Brain Research Center Symposium, Korean NIH.

2005 Dept. of Human Genetics, UCLA.

    2005 Department of Pathobiology, College of Veterinary Medicine, The University of

    Tennessee, Knoxville.

2005 RIKEN, Japan.

2005 Yokohama City University, Japan.

2006 Institute of Molecular and Cell Biology, Singapore.

    2006 The 83rd Annual Meeting of Physiological Society of Japan, Maebashi, Japan.

    2006 Center for Neurodegenerative Diseases, Emory University.

    2006 Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard

    University.

     nd2006 Ettore Majorana Foundation and Centre for Scientific Culture, 132 Advanced

    Course on “Estrogens and Human Diseases”, Erice, Sicily, Italy.

    2006 Committee on Cell Physiology Seminar Series, University of Chicago.

     nd2007 Section Chair, “Stress and Neurodegeneration”, 2 Indo-American Frontiers of

     Sciences Symposium, National Academy of Sciences, Irvine, CA.

    2007 Program of Pharmacology, Memorial Sloan Kettering Cancer Center, New York.

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