Scientists with the aid of transgenic mice reveals secrets of "painless"
[abstract] class people naturally do not feel pain, they carry a rare genetic mutation.Through transgenic technology, according to the university of London to carry such genes in mice, the researchers found a painless secret recipe.
The researchers by changing the mice genes to block pain signals
Some people naturally do not feel pain, they carry a rare genetic mutation.Before people want to use drugs reproduce this without the
pain, but the effect not beautiful., according to latest news website at university college London, through transgenic technology to carry such genes in mice, the researchers have finally found a painless secret recipe.
In 2006, researchers found that Nav1.7 sodium channel is particularly critical in the pain signal path, those born can't feel pain, their Nav1.7 channel failure.But to develop block Nav1.7 drugs, analgesic effect was disappointing.
This time, the researchers will be the same litter mice into genetically modified (gm) group and the control group, make transgenic mice with no pain of mutated genes.Experiments have shown that in the transgenic mice nerve system, its own produced by opioid concentration is about two times in the control group.
To test opioid the importance in the painless, the researchers gave the lack of Nav1.7 mice with an opioid blocker (naloxone), naloxone found that they can feel the pain again.Later the researchers gave a gene variant 39 women use, naloxone results for the first time she has the pain.
John wood paper's senior author said: "after nearly 10 years after a disappointing drug experiments, now we confirmed that Nav1.7 is indeed the key factors for human pain, the secret ingredient is ancient
opioid peptides, we have combined with low doses of opioid and Nav1.7 blockers method applied for a patent. It is expected to recreate those rare genetic variants to carry a person the sense with the painless experience, we have been successful experiments in normal mice this approach."
Local anesthetic broad-spectrum sodium channel blocker in long-term pain control is not appropriate, they lead to completely numb and serious side effects, and opioid painkillers such as morphine, pain relief is very effective, but the long-term use can produce chemical dependency and drug resistance.
"Combined with Nav1.7 blockers, inhibit opioid dose needed for the pain is very low."Wood explains, "Nav1.7 failure in life will produce low concentration of opioid, without resistance, no unpleasant side effects. We hope that you can use this method for 2017 human trials, help bring millions of patients with chronic pain of the world."