DOC

Traditional medicine and drug discovery

By Rebecca Hudson,2014-09-25 06:31
7 views 0
Traditional medicine and drug discoveryTrad

    Traditional medicine Traditional medicine

    and drug discovery and drug discovery

    F.Naghibi, M.Mosaddegh, F.Naghibi, M.Mosaddegh, Traditional Medicine and Materia Traditional Medicine and Materia

    Medica Research Centre Medica Research Centre

    (TMRC) (TMRC)

    Shahid Beheshti University of Shahid Beheshti University of

    Medical Sciences (SBUM) Medical Sciences (SBUM)

    Islamic Republic of Iran Islamic Republic of Iran

    LECTURE OUTLINE LECTURE OUTLINE ; The important of drugs in human ; The important of drugs in human

    being life( global drug issues) being life( global drug issues) ; Plants and drug discovery ; Plants and drug discovery ; Introducing HTS technology ; Introducing HTS technology ; conclusion ; conclusion

    The important of drug in The important of drug in

    humane being life humane being life ; Social ; Social

; Economical ; Economical

    CHALLENGES TO CHALLENGES TO

    HEALTH CARE IN A HEALTH CARE IN A

    WORLD WORLD

    OUT-OF-BALANCE OUT-OF-BALANCE ; Exploding population (6.83 bn Exploding population (6.83 bn ;

    now, 10.0 bn by 2035; a 40% now, 10.0 bn by 2035; a 40%

    increase) increase)

    ; Massive pantropical Massive pantropical ;

    deforestation deforestation

    ; Increasing fossil fuel use and Increasing fossil fuel use and ;

    global warming global warming

    ; New deadly and untreatable New deadly and untreatable ;

    global global

     diseases (SARS, Avian flu, diseases (SARS, Avian flu,

    etc) etc)

    ; Increasing drug resistance Increasing drug resistance ;

     (MRSA, VRSA) (MRSA, VRSA)

    ; Drugs for the North vs. South Drugs for the North vs. South ;

     - The Great Divide - The Great Divide

    THE GREAT HEALTH THE GREAT HEALTH

    CARE DIVIDE WHAT CARE DIVIDE WHAT

    IS IT? IS IT?

    ; In Ghana there are 110 In Ghana there are 110 ;

    people/traditional healer and 1 people/traditional healer and 1

    MD/21,000 people MD/21,000 people

    ; Per capita/year expenditures on Per capita/year expenditures on ;

    health care: US $6096; Ethiopia health care: US $6096; Ethiopia

    $ 21 $ 21

    ; Poor countries account for 56 % Poor countries account for 56 % ;

    of the global disease burden, but of the global disease burden, but

    less than 2 % of global health less than 2 % of global health

    spending spending

    ; Of 1556 new medicines Of 1556 new medicines ;

    approved in the past 30 years by approved in the past 30 years by

    the US FDA, only 1.3% (20) were the US FDA, only 1.3% (20) were

    for diseases prevalent in the for diseases prevalent in the

    developing world developing world

    ; Highly regulated Rx products vs. Highly regulated Rx products vs. ;

    Unregulated traditional Unregulated traditional

    medicines medicines

    A GLOBAL CAMPAIGN A GLOBAL CAMPAIGN

    FOR FOR

    ACCESS TO MEDICINES ACCESS TO MEDICINES

    Patents and prices Patents and prices

; The cost of originator/brand name The cost of originator/brand name ;

    antiretroviral therapy in 2000 -- antiretroviral therapy in 2000 --

    US$10,439 per patient per year, or US$10,439 per patient per year, or approx US$30 a day. approx US$30 a day.

    ; But, more than 2 billion people live on But, more than 2 billion people live on ;

    less than US$2 a day. Examples of GDP less than US$2 a day. Examples of GDP per capita (for 2002) in some developed per capita (for 2002) in some developed and developing countries: and developing countries:

    Norway/US$41,974 Sierra Norway/US$41,974 Sierra

    Leone/US$150 Leone/US$150

    US/US$36,006 US/US$36,006

    Mozambique/US$195 Mozambique/US$195

    UK/US$26,444 UK/US$26,444

    Zambia/US$361 Zambia/US$361

    WHAT ARE THE MAJOR WHAT ARE THE MAJOR KILLER DISEASES IN KILLER DISEASES IN

    THE WORLD? THE WORLD?

; AIDS: 3.1 m deaths per year, 5.5 m AIDS: 3.1 m deaths per year, 5.5 m ;

    new cases new cases ; Tuberculosis: 2 m deaths, 8 m new Tuberculosis: 2 m deaths, 8 m new ;

    cases cases

    ; Diarrheal Diseases: 1.9 m deaths, 2.7 Diarrheal Diseases: 1.9 m deaths, 2.7 ;

    bn new cases bn new cases ; Malaria: 1 m deaths, 300-500 m new Malaria: 1 m deaths, 300-500 m new ;

    cases cases

    ; Hepatitis B Virus: 1 m deaths, 10-30 m Hepatitis B Virus: 1 m deaths, 10-30 m ;

    new cases new cases

; SARS: 04/04, 8,096 cases, 774 SARS: 04/04, 8,096 cases, 774 ;

    deaths (648 in HK/China) deaths (648 in HK/China)

    ; Avian flu: 06/07, 310 cases, 189 deaths Avian flu: 06/07, 310 cases, 189 deaths ;

; Tobacco-related: 3.5 m deaths Tobacco-related: 3.5 m deaths ;

    (cancer, lung) (cancer, lung)

    A GLOBAL HEALTH A GLOBAL HEALTH

    CARE CRISIS IS CARE CRISIS IS

    COMING! COMING! ; Getting a Rx drug to market Getting a Rx drug to market ;

    costs $1 bn costs $1 bn

    ; Drugs too expensive Drugs too expensive ;

    ; No drugs for critical global No drugs for critical global ;

    diseases diseases

    ; Cannot provide the world Cannot provide the world ;

    with synthetic drugs not with synthetic drugs not

    sustainable long term sustainable long term

    The necessity of drug The necessity of drug

    discovery discovery ; Incurable diseases ; Incurable diseases

; Resistance ; Resistance

; New diseases ; New diseases

    ; Pharmaceutical industry ; Pharmaceutical industry

    business business

    Definition: Definition: Drug discovery is a knowledge Drug discovery is a knowledge

    of ; of ;

     designing, designing,

     synthesising, synthesising,

     screening, screening,

     biological testing, biological testing,

     Pharmaceutical Pharmaceutical

    evaluating, evaluating,

     to introduce a novel compound to introduce a novel compound

    or at least lead compound for or at least lead compound for

    specific disease specific disease

    Starting points for drug Starting points for drug

    discovery discovery

    ; Chemical components ; Chemical components

    ; Biotechnological components ; Biotechnological components

; Natural components ; Natural components

    Approaches to drug Approaches to drug discovery using higher discovery using higher

    plants plants

    ; Random selection followed by ; Random selection followed by

    chemical screening chemical screening

    ; Random selection followed by ; Random selection followed by

    one or more biological assays one or more biological assays ; Follow up of biological activity ; Follow up of biological activity

    reports reports

    ; Uses of database such as ; Uses of database such as

    NAPRALERT NAPRALERT

    ; Follow up of traditional uses of ; Follow up of traditional uses of

    plants plants

    What are the most important What are the most important

    Issues on traditional Issues on traditional

    medicine? medicine?

    ; Where will nations get health care if Where will nations get health care if ;

    drugs from the North are not available drugs from the North are not available

    or too costly? or too costly?

    ; Traditional medicines are a Traditional medicines are a ;

    fundamental aspect of basic health fundamental aspect of basic health

    care needs globally care needs globally

Report this document

For any questions or suggestions please email
cust-service@docsford.com