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Reference ranges revised 02232011

By Warren Anderson,2014-04-17 23:18
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Reference ranges revised 02232011

    NBS TEST CUT-OFF/REFERENCE RANGES - 2/23/2011

     Acylcarnitine Reference Range FC > 7 < 125 ;mol/L FC / ( C16 + C18:1 ) Ratio < 75 C-2 > 1.5 < 80 ;mol/L C-3 < 6.3 ;mol/L C03 / C02 Ratio < 0.3

    C-3DC < 0.4 ;mol/L C-3DC / C-10 Ratio < 5

    C-4 < 1.7 ;mol/L C-5 < 1 ;mol/L C-5 / C-3 Ratio < 0.45

    C-5:1 < 0.6 ;mol/L C-5OH < 0.9 ;mol/L C-5DC < 0.6 ;mol/L C-6 < 0.95 ;mol/L C-8 < 0.6 ;mol/L C08 / C10 Ratio none

    C-8:1 < 0.7 ;mol/L C-10 < 0.65 ;mol/L C-10:1 < 0.45 ;mol/L C-12 < 2 ;mol/L C-12:1 none

    C-14 < 1.2 ;mol/L C14:1 < 0.8 ;mol/L C14:1 / C12:1 Ratio none

    C14:2 none

    C-14OH < 0.2 ;mol/L C-16 < 10 ;mol/L C-16:1 < 1.4 ;mol/L C-16OH < 0.1 ;mol/L C16OH / C16 Ratio <0.07

    C-18 <4 ;mol/L C-18:1 <7 ;mol/L C-18:2 none

    C-18OH < 0.1 ;mol/L C-18:1OH < 0.1 ;mol/L Amino Acid Reference Range

    Glycine none

    Alanine < 1000 ;mol/L Valine none

    Valine/Phenylalanine Ratio <3.5 Leucine/Isoleucine < 250 ;mol/L Leucine/Alanine Ratio <1.3

    Phenylalanine < 155 ;mol/L Phenylalanine/Tyrosine Ratio < 1.5 Tyrosine < 850 ;mol/L Succinylacetone < 4.5 ;mol/L Methionine > 8 to < 100 ;mol/L Citrulline > 5 to < 60 ;mol/L Citrulline/Arginine Ratio < 6 Ornithine < 800 ;mol/L Ornithine/Citrulline Ratio none Arginine < 50 ;mol/L Arginine/Ornithine Ratio < 1.4 Proline < 1500 ;mol/L 5-Oxoproline none

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    NBS TEST CUT-OFF/REFERENCE RANGES - 2/23/2011

     Other Analytes Reference Range

    Immunoreactive Trypsinogen < 62 ng/mL

    Biotinidase > 10 ERU

    Galactose -1 -uridyl transferase > 50 enzyme units TSH < 25 mlU/L

     Congenital Adrenal Hyperplasia Birth Weight Urgent Cutoff Indeterminate Cutoff

    17 Hydroxyprogesterone (17 OHP) <1000g 200 nmol/L 80 nmol/L

    17 Hydroxyprogesterone (17 OHP) 1000-1499g 90 nmol/L 80 nmol/L

    17 Hydroxyprogesterone (17 OHP) 1500-2499g 80 nmol/L 55 nmol/L 17 Hydroxyprogesterone (17 OHP) >2500g 70 nmol/L 50 nmol/L

     Second Tier CAH Reference Range

    17 Hydroxyprogesterone (17 OHP) < 38 nmol/L

    Cortisol none

    Androstenedione none

    (17 OHP+Androstenedione)/Cortisol Ratio < 1

    Screen for 2nd Tier CAH based on 17-OH P level and a steroid ratio level.

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