Neonatal jaundice analysis of 407 cases
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[Abstract] Objective of 407 cases of neonatal hospital pathological analysis of the cause of jaundice. Methods 407 cases of newborn jaundice causes of disease classification statistics. G6PD deficiency hospital accounted for the results of the third. Conclusions Neonatal jaundice disease due to infection, followed by the breast factor, G6PD deficiency in third place.
[Keywords:] newborn; pathologic jaundice; G6PD deficiency
Department of neonatal jaundice common, if high blood unconjugated bilirubin in the neonatal period can cause encephalopathy, can often result in death or serious sequelae such as mental retardation, hearing impairment, cerebral palsy and so on. So to For each cause of jaundice in time to find
out as soon as possible intervention to prevent bilirubin encephalopathy. now our hospital in August 2008 on October -
2009 diagnosed as "pathological neonatal jaundice," the treatment of neonatal hospital 407 children were analyzed as
follows.
1 Clinical data
1.1 The diagnostic criteria of neonatal pathological jaundice [1] where one of the following conditions: (1) jaundice appeared early (24h in); (2) severe jaundice, serum bilirubin> 205??mol / L (12mg/dl); (3) jaundice too long: term
children> 2 weeks, premature children> 4 weeks; (4) jaundice retreat reproduction; (5) serum bilirubin> 26??mol / L (1.5mg/dl).
1.2 General Information of 407 cases of pathologic jaundice in newborn male and 236 cases, 171 cases of women; gestational
age 35 to 41 weeks; premature children in 18 cases, 389 cases of full-term children; onset age 0 to 2 days and 60 cases, 3 14 days of 180 cases, 167 cases from 15 to 28 days.
2 Classification of neonatal pathological jaundice and analysis of statistical results in Table 1 to 3.
Table 1 407 cases of neonatal jaundice causes of disease Table 2 G6PD deficiency Schedule 3 G6PD deficiency and the incidence of serum bilirubin values
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3 Discussion
This data showed that neonatal common cause of pathologic jaundice system infection, as China's great efforts to promote breastfeeding, breast milk jaundice gradually increased. G6PD deficiency in our hospital accounted for the etiology of neonatal pathological jaundice third, indicating that the disease should be taken seriously. G6PD deficiency [1] Department of the lack of red blood cell glucose-6-phosphate
dehydrogenase (commonly known as broad bean disease), a number of factors in the pathogenesis of more red blood cells was
mainly due to reduced coenzyme ?? generation capacity is not enough to maintain normal antioxidant ability to cope with the sudden increase in peroxidation, oxidative damage due to excessive red blood cells and hemolytic jaundice caused
extensive damage. of high incidence of Sichuan, Guangdong, Guangxi, Yunnan, Fujian, Hainan and so on. The disease is X linked incomplete dominant genetic diseases, high incidence of male to female, male and female heterozygous homozygous disease. jaundice in the newborn period usually presents earlier, jaundice, rapid development, sustained and fade over time, especially in the infection, lack of oxygen, acidosis, have oxidation characteristics of drug use or exposure to mothballs or medicine outside the yellow fruit such as
washing, can significantly increase the disease condition, the individual can cause severe hemolytic anemia and bilirubin encephalopathy. follow-up 1 case serum bilirubin> 342??mol / L male children, because family members do not listen to
discourage signature to refuse treatment, follow-up revealed a
large brain in children with movement disorders. The disease is currently no cure, focus on prevention, early detection, timely treatment of neonatal jaundice and correct anemia and
prevent the occurrence of bilirubin encephalopathy. The municipal high incidence of the disease, infants born in the maternity hospital were taken to do neonatal blood screening, screening for the disease is one of them. and neonatal
patients in the general pumping blood to do G6PD ratio method confirmed the disease, early detection of the disease can be easy to control, timely treatment and provide guidance, distribution of the disease Health prescription, specify medication and contact items Notes and carry to facilitate
future convenience sick infants and young children for treatment, medication guidance, thus reduce the occurrence of hemolysis and jaundice, is conducive to children's Healthy development.
[References] 1 Wang Mu Di. Paediatrics, 4th ed. Beijing:
People Health Press ,1997:105-108; 333-335.
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