Maternal ABO blood type antibody titer determination of the significance of hemolytic disease of newborns
[Keywords:] Mother child blood group incompatibility, ABO antibody titer, hemolytic
Parent child blood group incompatibility is a high-risk
pregnancies, more common ABO blood group incompatibility in, ABO blood group incompatibility hemolytic disease of newborn due to have been confirmed with the blood type theory of an important disease. Can cause miscarriage, stillbirth,
stillbirth, severe anemia, neonatal bilirubin encephalopathy, mental retardation and other diseases, has been included in an important part of perinatal care of pregnant women. For couples pregnancy ABO blood group determination and detection of maternal ABO antibody titer to understand the potency and the incidence of hemolytic disease of newborn relationship between the prevention of hemolytic disease of newborns is very valid. to improve the population quality, our hospital since March 2007 began to carry out determination of ABO blood type antibody titer (mainly for the 0-type pregnant women,
husbands blood type as A, B, AB type), are as follows.
1 Subjects and methods
1.1 Detection of objects selected from our hospital the past two years, cases of out-patient treatment of pregnant women, a total of 279 patients, aged 19 to 41 years old, average age 26.7 years, and pregnant women, blood type is 0, the husband as the A, B, AB blood type accounted for 251 cases ; the rest for other cases.
1.2 Detection Methods saline tube agglutination method, pregnant women or anti-B IgG anti-A antibody titers of the ABO
blood group testing. Antibody titer greater than 1:64 for the exception, less than 1:64 as normal.
279 cases of blood type O African pregnant women in 28
cases, the blood type antibody titers were ?? 1:64, the line is not special treatment, 19 patients without significant jaundice, other 9 patients with mild jaundice, even after untreated cases of self-improvement .251 O-blood of pregnant
women, 132 cases of exception, the serum antibody titer ABO blood group test results and the number and percentage of incidence in Table 1. Table 1 251 pregnant women, blood group titer the number of cases and development
Maternal blood group incompatibility hemolytic disease of the newborn ABO blood group incompatibility with the most common cause of neonatal hyperbilirubinemia about 20%. O-blood
of pregnant women as natural antibodies IgG, the fetus through the placental barrier into the blood, resulting in destruction of fetal red blood cells. Therefore, ABO blood group incompatibility mainly seen in the mother blood type O, while the fetal blood type is A or B cases. Such infant blood group incompatibility can cause hemolysis, severe hemolysis can
cause stillbirth, habitual abortion; neonatal hemolytic Without timely treatment, possible neonatal bilirubin encephalopathy, or even infant death. trimester maternal blood group antibody titers were measured, and early parent child
blood group incompatibility forecasting, early intervention. If the blood is only slightly higher antibody titers, TCM supplemented with vitamins and energy to support high-sugar,
you can control; heavy Integrative Medicine who the baby after birth can reduce symptoms of hemolysis, the joint Blu-ray
irradiation after birth, lose of fresh plasma, blood transfusion and other treatment, healing effect. Therefore, it is targeted for determination of ABO blood type antibody titer, low titer observed abnormalities in early intervention,
the work of prenatal and postnatal care and improve population quality is important.
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