Lhasa hemorheology of polycythemia_10005

By Brian Payne,2014-11-02 09:44
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Lhasa hemorheology of polycythemia_10005

Lhasa hemorheology of polycythemia




     [Abstract] Objective To investigate the Lhasa City altitude polycythemia (HAPC hemorheology of patients. Methods 105 patients and 782 cases HAPC plateau of blood viscosity in healthy population were analyzed. Results HAPC blood relative viscosity and hematocrit than the plateau was significantly higher in healthy population. Conclusion living population due to environmental oxygen plateau, blood compensatory increase in the number of red blood cells, so that increased hematocrit and hemoglobin increased, causing the viscosity increased, so that the deformation of red blood cells decreased, caused by increased whole blood viscosity.

     [Key Words] high altitude polycythemia, hemorheology

     Tibet regional average altitude of 3,700 meters, where air pressure is low, air is thin, the oxygen content of less than 40% of the plain areas. Living in such hypoxic conditions, the body tissues and organs of oxygen supply to demand, it will compensatory increase caused by human red blood cells, so that the hematocrit increased, while hemoglobin also increased, resulting in more patients with polycythemia. To understand the high altitude polycythemia Hemorheology, we altitude of 105 patients with polycythemia disease (high altitude

    polycythemia, HAPC patients and 782 cases of high altitude results of blood rheology in healthy population were compared, patients with high altitude polycythemia increases blood viscosity, especially in hematocrit (hematocrit, HCT

    increased. now Rheology of the disease in terms of impact report is as follows.

     An object and methods

     1.1 The subjects were 105 patients in this group, all patients in our hospital, including patients with high altitude polycythemia male 99, female 6, aged 31 to 72 years,

    782 cases of the control group, derived from normal, healthy hospital one examination, 672 cases were male, female 110

    cases, aged 22 to 68 years, no other specific diseases by physical examination.

     1.2 Methods subjects fasting blood 2ml, heparin, a

    concentration of 20IU/ml, equipment used for a domestic LG-R

    tester 80A blood viscosity, hematocrit (HCT) with Wen's method, all data are (+-s) that the results were analyzed by t test.

     2 Results

     105 cases and 782 cases of healthy blood rheology control

    (+-s), see Table 1. Form 1105 cases and 782 cases were healthy blood flow changes were compared (abbreviated)

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     3 Discussion

     Hematology parameters RBC> = 6.5 ?? 1012 / L, Hb> = 200g /

    L, HCT> = 65% can be diagnosed with HAPC [1]. Patients occurs mainly in men, women and children, rare in this group of men Lord, 99 were female, only 6 cases. HAPC may occur with the oxygen content decreased RBC glutathione, methemoglobin content increased, reducing the oxygen carrying capacity of red blood cells, hypoxia increased, kidney due to hypoxia increase the secretion of erythropoietin increase, leading to increased blood viscosity, blood flow slows down, vascular resistance increased, decreased blood oxygen binding, and

    induced HAPC, the blood circulation disorder, caused by a change in the body. Therefore, the blood flow in patients with HAPC rheology has a "thick, sticky, together, pour" feature [2].

     Red blood cells with high altitude polycythemia is a

    proliferation of mainly red blood cell count and the absolute increase in blood volume, making the blood viscosity increased, compared results from Table 1, both in patients with polycythemia, the whole blood viscosity in the shear rate When the 200,30,5,1, showed significantly higher (P <0.01), HCT also showed significantly higher (P <0.01). there These results suggest that, HAPC the blood flow in patients Rheology results HCT is caused by increased blood viscosity, an important factor, normal blood hematocrit about 45%, while the total volume of red blood cells account for about 95% in

    patients with erythrocytosis due to the number of red blood cells significantly increased, platelet count increased, the total capacity of the blood more than normal 1 to 3 times,

    resulting HCT significantly increased blood viscosity can be increased from 5 to 8 times normal, resulting in deposition of blood, causing a series of clinical syndrome.

     [References] [1] General Hospital of Tibet Military Code. Altitude Diseases [M]. Lhasa: Tibet People's Publishing House, 2001,263. [2] Hao Chen, Li Xian, sub-Ren Dawa, and so

    on. Hyperbaric oxygen therapy on patients with high altitude polycythemia hemorheology [J]. Clinical Internal Medicine, 2003,20 (8) :435-436.

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