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CHINESEJOURNAL

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CHINESEJOURNALCHINES

    CHINESEJOURNAL

ChemicalC0nstituentsfromFlueggeavirosa

    ;WANGGuoCai,LIANGJiePing2,

    ;WANGYing2,

    ;LIQian2,YEWen-Cai’

    ;DepartmentofNaturalMedicinalChemistry,ChinaPharmaceuticalUniversity,Nanjing210009;

    ;InstituteofTraditionalChineseMedicine&NaturalProducts,JinanUniversity,Guangzhou510632,

    ;China

    ;Anewcompound,11OacetylbergeninwasisolatedfromFlueggeavirosawitheight ;knowncompounds.

    ;[FoundationItem]ThisprojectwassupportedbytheChinaPostdoctoralScienceFoun

    ;dation(No.20070410841)

    ;ChinJNatMed,2008,6(4):251-253

    ;“2

    ;i

    ;c

    ;/~N

    ;c

    ;o

    ;O

    ;ThreeTritserpeneGlycosidesfromSeaCucumberCucumariafrondosa ;Gunnerus

    ;LAMingPing,YIYangHua,LILing,LUBiDe,HANHua,WANGZengLei,GO

    NGWei

    ;ResearchCenterfo,MarineDrugs,SecondMilitaryMedicalUniversity,Shanghai ;200433,China

    ;ThreetriterpeneglycosideswereseparatedfromCucumariafrondosaandtheir ;structureswereelucidatedasfrondosideA6f1.frondosideA(2)andfrondosideAl ;f3,.FrondosideA6isnew.

    ;FoundationItem]ThisprojectwassupportedbytheNationalHighTechnology ;ResearchandDevelopmentProgramFoundation(863Program,No. ;2006AAO9Z47)andShanghaiLeadingAcademicDisciplineProject(B906) ;ChinJNatMed,2008,6(4):254-258

    ;ANewDihydrochalconeGlucosidefromLongdanXieganDecoction ;WANGYun,ZHANGZhang,YANGLi,CHOUGui.Xin,WANGZheng—Tao’,

    ;DepartmentofPharmacognos~ChinaPharmaceuticalUniversity,Nanjing210038; ;KeyLaboratoryofStandardizationofChineseMedicinesofMinistryofEducation, ;ShanghaiUniversityofTraditionalChineseMedicine,Shanghai201203,China

;Anewcompound,2.,4idmydr0xydmydrochacone3’Cglucopyranoside

    6’

    ;DDglucopyrano?side(1),withfourknowncompouds,wasisolatedfrom ;LongdanXieganDecoction.

    ;[FoundationItem]ThisprojectwassupportedbyNationalNaturalScience ;FoundationofChina(30530840)&NationalBasicResearchProgramofChina ;(2OO6CB5O47O4)

    ;ChinJNatMed,2008,6(4):259261

    ;0H0

    ;InteractionsofFufangDanshenPrescriptionwithLiposomeBiomembrane ;ZHOUPeng,LIPing,WEIYing.Jie

    ;ChinJNatMed,2008,6(4):278-282

    ;KeyLaboratoryofModernChineseMedicines,MinistryofEducation,DepartmentofPharmacognosy,ChinaPharmaceuticalUniversity,210038

    ;Nanjing,China

    ;IthasbeenfoundthattwentyfourconstitutesinFufangDanshenPrescription(FDP)interactwithliposomeobviously.Amongthem,

    ;eighteencompoundswereidentifiedincomparisonwiththestandardsintermsofUVspectrum.MSdataalongwithretentiontime.Liposome

    ;equilibriumdialysissystemcoupledwithHPLCandLC/TOF/MScouldsimplyandeffectivelyestimatetheabsorptionofmultiplecomponents

    ;inFDPinvivo,andpredictsthepotentialbioactivityofthesecomponents,andthuscontributestotheinvestigationofbioactivecompounds

    ;withcurativeeffectinFDP

    ;

    FoundationItem]ThisprojectwassupportedbytheNationalNaturalScienceFoundationofChina(No.30530870)

    ;?.W..

    ;

    ;J

    ;ChinJNatMed,2008,6(4):283-291

    ;IdentificationofMainChemicalComponentsofTongguanwanPrescriptionbyHPLC-ESI?MS/MS

    ;LUXinRu,QMin-Jian?,XUDeRan

    ;SchoolofTraditionalChinesePharmacy;

    ;KeyLaboratoryofModernChineseMedicines,MinistryofEducation,ChinaPharmaceuticalUniversity,Nanjing210038,China

    ;TwelvecompoundswereidentifiedinTongguanwan(aprescriptionoftraditionalChinesemedicine)byHPLCESIMS/MSwhich

    ;wereneomangiferin,mangiferin,timosaponinBII,anemarsaponinE,timosaponinB

    HI,timosaponinAIII,phellodendrine,magnoflo

    ;rine,menisperine,berberine,jatrorrhizineandpalmatine.TheresultssuggestHPLCMS

    /MSisarapidandaccuratemethodtoidentifythe

    ;compositionsofprescription.

;ChinJNatMed,2008,6(4):292-297

    ;InvestigationofPicrosideIItSImpactontheP450ActivityUsingaCocktailMethod ;XIAOYa-Jie,JIANGZhen.Zhou,YAOJinCheng,HUANGXin,HUANGJing-Feng,

    WANGTao,ZHANGLuYong

    ;TheNationalCenterforDrugScreening,ChinaPharmaceuticalUniversity,Nanjing210038,China

    ;TheeffectsofpicrosideIIonP450activitiesinratswereevaluated.Resultsshowedthattherewerenodiflferencesintheplasma

    ;concentrationsofthefiveprobesandtheircorrespondingpharmacokineticparametersinratsaftersingledosingofpicrosideII(10

    ;mg?kg..).TheAUCo.tandthedrugconcentrationofomeprazoleincreasedsignificantly(JP<O.O5)inratsaftermultipledosingofpicroside

    ;II(10mg?,orally,twicedailyfor12consecutivedays).SingleadministrationofpicrosideIIhadverylittleimpactontheactivitiesof

    ;P45OwhilemultipleadministrationofpicrosideIItendedtoinhibitCYP2Cl9activity. ;

    FoundationItem]ThisprojectwassupportedbytheSpecialFundofPublicInterestResearchofTradifionalChineseMedicine.Min,

    ;istryofFinance(No.200707008)

    ;ChinJNatMed,2008,6(4):298-301

    ;CellularAbsorptionofEmodinInfluencedbyAnthraquinOnesinHumanIntestinalCaco-2Cells

    ;LIUChunHui,JIANGZhenZhou,HUANGXin,WANGCuiFen,DUANWeiG

    ang,YAOJinCheng,LIUJing,WUXuDong,

    ;ZHANGLu—Yongl’2’3’

    ;:JiangsuCenterforDrugScreening;

    ;JiangsuCenter#,PharmacodynamicsResearchandEvaluation;

    ;KeyLaboratoryofDrugQualityControlandPharmacovigilance,MinistryofEducation,ChinaPharmaceuticalUniversity,Nanjing

    ;210009;

    ;:D~artmentofPharmacology,SoutheastUniversity,Nanying210009;

    ;DepartmentofPharmacology,YunanUniversityofTraditionalChineseMedicine,Kunming,650200,China

    ;IthasbeenfoundthattheabsorptionofemodininhumanintestinalCaco??2cellswasreducedbyaloe??emodinandphyscioncon??

    ;spicuously.Theresultssuggestthatthemixtureofemodinwithotherfreetotalrhubarbanthraquinones(TRAs)couldbemoreeffectively

    ;andsafely.

    ;[FoundationItem]ThisprojectwassupportedbythegrantfromStateAdministionofTraditionalChineseMedicineofthePeople’s

    ;RepublicofChina(0405ZP32)

    ;ChinJNatMed,2008,6(4):307-311

    ;CloningofactinPromoterandTransformationoftheMarine?SourcedFilamentousFungus

;PhomaherbarumY$4108

    ;ZHOUTian,FENGMing-Qian,WEIWenJie,TANRenXiang,SONGYong.Chun

    ;InstituteofFunctionalBiomolecules,StateKeyLaboratoryofPharmaceuticalBiotechnology,NanjingUniversity,Nanfing210093,China

    ;Theactinpromoterwassuccessfullycloned.TheoptimumparametersforelectroporationwerefoundtobeO.75kVrO.2cmca

    ;vette)involtageand400ninresistancewith9/agofplasmid,underwhichmorethan100transformantspercuvette(10recipients)could

    ;beobtained.Byusingtheendogenousactinpromoter.theelectrictransformationsystemofJP.herbarumYS4lO8wasestablished.which

    ;servedasapracticalapproachfortransgenicstudyonthisfungus.

    ;[FoundationItem1111isprojectwasspportedbytheMinistryofScienceandTechnology(NationalMarine863Projects,No.

    ;2006AA090300and2007AAO9Z4OO1

    ;

    ;

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