Summary by Jan Schaap
From The National Institutes of Health and The Centers for Disease Control:
; Almost 62 million Americans have at least one type of cardiovascular disease.
; Every twenty-nine seconds, an American has what doctors call a “coronary event,”
such as a heart attack. A death occurs from these events about once every minute.
; One out of every two Americans will die from cardiovascular disease.
; Cardiovascular disease claims as many lives each year as the next seven leading
causes of death combined.
; Every fifty-three seconds, someone in the United States has a stroke. A death from a
stroke takes place every three minutes.
; Cardiovascular disease affects women as well as men. Women actually outnumber
men in the prevalence of cases of cardiovascular disease and in related deaths, with
about 53 percent of the deaths from cardiovascular disease occurring in women.
Although studies repeatedly show that women are much more anxious about
developing breast cancer than cardiovascular disease, one of every 2.4 deaths in
women is caused by cardiovascular disease, compared to one in thirty from breast
“Repairing the damage wrought by cardiovascular disease without risky and often ineffective surgery had long been considered impossible. I was awarded the Nobel Prize in Medicine for making that thinking obsolete. Now we know we can reverse cardiovascular impairment naturally with the body’s own internally manufactured “wonder drug” nitric oxide. Medicine is on the brink of rethinking the protocols for treating heart disease –
largely on the basis of nitric oxide.” ~ Dr. Louis Ignarro
Nitric oxide (NO) is a powerful signaling molecule present in the cardiovascular and nervous systems as well as throughout the body. NO penetrates membranes and sends specific messages or biological signals that regulate cellular activity and instruct the body to perform certain functions. NO influences the functioning of virtually every bodily organ, including the lungs, liver, kidneys, stomach, genitals, and, of course, the heart.
Some of the many vital duties nitric oxide performs:
; VASCULAR TONE: NO MORE HIGH BLOOD PRESSURE
By enhancing the free flow of blood through the body, nitric oxide protects the blood
vessels’ smooth muscle tissue from harmful constriction as it safeguards the
health of the endothelium, resulting in no more high blood pressure.
; COAGULATION: NO MORE BLOOD CLOTS
By keeping the blood pumping regularly through the vascular system, nitric oxide
maintains the blood vessels and arteries at a prime level of cleanliness. Remember,
unhealthy vessels and arteries act like Velcro, attracting and attaching to dangerous
foreign matter; while a nitric oxide-enhanced vascular network performs like Teflon,
shedding plaque and platelets, inhibiting clots from expanding or from forming in the
; INFLAMMATION: NO MORE ATHEROSCLEROSIS
The development of atherosclerosis is a gradual, dynamic inflammatory process,
taking many years for plaque to develop. Nitric oxide can intervene early in the
process, preventing the thickening of the walls of the arteries and the buildup of fatty
; OXIDATION: NO MORE OXIDATIVE STRESS
To get a clearer image of oxygen free radicals, picture an automobile that burns
gasoline for energy, and in the process, generates exhaust filled with harmful
pollutants that can turn blue skies to brown. In much the same way, your body relies
heavily on oxygen for its energy, but as this energy is being used, it creates its own
byproduct of “exhaust” – namely free radicals. These free radicals are sometimes
ormed in excess. When that happens, this oxidative stress clearly becomes f
detrimental to your well being, damaging healthy cells and tissues, including those in
the arteries. Nitric oxide can minimize the oxidative stress that contributes to
SAY YES TO NO-BOOSTING ANTIOXIDANTS
Antioxidants act like scavengers in the body, searching for free radicals and neutralizing
them before they can cause much damage. With the primary goal of preserving and
maximizing the efficacy of nitric oxide, these are the four antioxidants you should be taking: ; VITAMIN C (Recommended dosage: 500 mg per day)
o Stimulates the healing of wounds.
o Help in the absorption of iron from the intestinal tract, thus reducing the risk
of iron-deficiency anemia.
o Plays a critical role in the production of various antibodies that can resist
bacteria and viruses.
o Guards the body against free radicals.
; VITAMIN E (Recommended dosage: 200 IU per day)
o May play an important role in interfering with the inflammatory processes
within your body, which are known to exacerbate cardiovascular disease.
o Appears to impede the formation of LDL cholesterol.
o Many studies now confirm that vitamin E can undermine oxidative stress
within the body. As it does, it neutralizes free radicals before they can cause
cardiovascular or other serious diseases.
; FOLIC ACID (Recommended dosage: 400-800 mcg per day)
o Can reduce the levels of homocysteine, an amino acid that is a risk factor for
; ALPHA LIPOIC ACID
o ALA can trigger chemical reactions in the body that increase or recycle the
levels of other key antioxidants, including vitamins C and E.
o It can increase the amount of nitric oxide, as well as improve the stability and
duration of the action of NO.
o It can facilitate glucose metabolism and is often recommended for people with
“The difference between health and illness is often a function of the level of NO in your body. NO can literally be a matter of life and death. ~ Dr. Louis Ignarro
SAY YES TO NO-BOOSTING SUPPLEMENTS
Other essential amino acids that play a critical role in the body’s ability to produce nitric oxide are L-arginine and L-citrulline. L-citrulline, as we know, is an amino acid that is utilized by the vascular endothelial cells and converted into L-arginine, thereby providing even more “fuel” to produce nitric oxide. Recommended dosage of L-arginine: 4-6 g (4000-
6000 mg) per day. Recommended dosage of L-citrulline: 200-1000 mg per day.
SAY YES TO NO-BOOSTING FITNESS!
; The acceleration of blood flow that occurs during exercise can stimulate the
production of the enzyme NO synthase, which is important for the body’s production
of nitric oxide.
; Regular physical activity can reduce blood pressure and cholesterol levels.
; Exercise prevents blood platelets from adhering to vessel walls, lowering the
likelihood of plaque accumulation and blood clotting.
SAY YES TO NO-BOOSTING NUTRITION
Heart Friendly Fats
Any fat – good or bad is high in calories and should be used sparingly. Here are fats recommended by the American Heart Association.
Canola oil Light and dark sesame oil
Corn oil Vegetable oil
Safflower oil Pure and virgin olive oil
High intake of dietary fiber helps lower the rate of coronary artery disease. Gradually work your way up to 25 grams of fiber per day by eating:
Vegetables (raw or steamed) Brown rice
Whole-grain breads and cereals Nuts and seeds
Beans and peas
The following seafoods are great sources of omega-3 fatty acids and NO-producing proteins.
Functional Foods to Keep You Heart-Healthy
Below is a list of foods with the uniquely powerful capacity to protect your cardiovascular health.
Egg whites Dark chocolate
Garlic Red wine
Green Tea Grape juice
Soy Pomegranate juice
“Winning the 1998 Nobel Prize in Medicine, the culmination of my professional life,
confirmed that my decades of research had produced a breakthrough that would profoundly and permanently alter medical science. My colleagues, Ferid Murad and Robert Furchgott, and I had discovered “the atom” of cardiovascular health – a tiny molecule called nitric
oxide. NO – as it is known by chemists – is produced by the body specifically to help keep
arteries and veins free of the plaque that causes stroke and to maintain normal blood pressure by relaxing the arteries, thereby regulating the rate of blood flow and preventing coronaries. Nitric oxide is the body’s natural cardiovascular wonder drug.”
~ Dr. Louis Ignarro
THE NO BENEFITS THAT AWAIT YOU
“Preventing cardiovascular disease always goes back to the choices you make. It’s up to you to create an environment that lets NO do its’ job.” ~ Dr. Louis Ignarro
Dr. Ignarro’s “Say Yes to NO” program has the potential to restore the normal production and activity of nitric oxide in your body, and in turn, improve your cardiovascular health. Following his plan will:
; Lower your blood pressure
; Improve your circulation
; Delay the onset or progression of atherosclerosis
; Reduce your likelihood of (and possibly prevent) having a heart attack or a stroke
“These are not unfounded, unsubstantiated claims. Grounded in science, these claims are supported by studies in my own lab at the UCLA school of Medicine and by many other research scientists around the world.
No matter what your age or physical condition, you can put your body’s NO to work
effectively by adopting my recommendations.
When you say yes to NO, you do your heart and body good.”
~Dr. Louis Ignarro
1 Ignarro, Louis J., Ph.D., NO More Heart Disease, 2005, Healthwell Ventures by Saint Martins Press * [Note: These statements have not been evaluated by the Food and Drug Administration. This information or product is not intended to diagnose, treat, cure or prevent any disease.]