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Polymorphisms

By Emily Rodriguez,2014-02-18 17:51
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Polymorphisms

    Polymorphisms

Wcobserve(1allincreasedriskoi'ESC(associatedwithtilel'53J

    ro/I'ro(()R,1.83;95%Cl,1.432.35;P<0.001)

    orMI)M2(;(j(OR,1.49;95%Cl,1.161.91;lJ

    0.002)gcnotype,comparedwiththe1'53Arg/ArgorMDM211, gcnotype.rcspectivclyInteractionbetweentheseP53a1]dM1)M2polylnorphismsincrease

    driskofESCCi11a

    multiplicafivc111allllcr,withthe0Rbeing3.0(95%CI,2.07

    4.69)forSt1bectscarryingbothP53Pro/Proand

    MDM2GGgcnotypcs.Significantinteractionswereobservedbetweenthesepolylnorphisn

    ~andsmoking.with

    riskbeingtilehighest(OR,5.29;95%C1,2.9

    9.61)insmokershavingboth1'53Pro/ProandMDM2GGgenotypcs. lhcM1)M2GGgenotypcwasalsoassociatedwithriskofdevelopingpoorlydifiercntiatedan

    dadvancedESCCcorn

    paredwiththeG1'()rll'genotypc(ORforhigh-gradealldstapesIIIIVversuslow

    gradeandstagesIII=:1.60;

    95%(:l'1,0(2.64;l.().049).qhel

    53andM1)M2tx)lynlolphislllSnmybcoenetic{tetcnnil]~lntstbrthedevclo~ncntofESCC.

    Kcywords:CO1)ON72p()IYM()RllIISM:CNCF.RMORTIITY:(:IIIN

    :GENE;PROfEIN:

    MPLIFICTION;MET人人NI.YSIS;SSOC1T10N:

    PO1l,()SIS:IR0MOTER

    C/1NCERRESEARCH2005.65t2o:95829387

    PolymorphismsinI)NAbaseexcisionrepairgenesAI)PRTandXRCC1and riskoflungcancer

    ZhangXM,MiaoxP,LiangG,IIaoI3lWangYG,FanW,LiY'OuoYL,HcFC,WciQY'LinDX ChineseAcadMedSci,lnstCane,DeptEtiol&Carcinogel1esis,Belling,10002IPeoplesRChina

    ChineseAcadMedSci,Canehlst&fIosp,DeptThoracSurg,lleijing,l0002IPeoplesRChina

    PekingUnionMedCoil,Beijfilg,PeoplesRChina

    l'singhuaUniv,1)eptBiolSci&Biotechnol,Belling,PeoplesRChina BellinghlstRadiatMed,LabSystBiol,Beijiilg,PeoplesRChina

    NChinaCoalMedCoil,1)eptSciBiol,Jlebei,PeoplesRChina

    tJni~,t'exas,MI)AndersonCaneClr,1)eptEpidcnliol,Jlouston,I'X77030tJSA Abstract:Adenosinediphosphatcribosyltransfcrase(ADPRT)andXrayrepaircross

    complementingI(XRCC1)

    aretwolnajorI)NAbaseexcisionrepair(1j

    R)proteinsandactinteractivelyillstimulatingandexecutingBEl1.

    processes.1}olylnorphiSlllSofDI'ITVa1762

    laandXRCC1Arg399Glnhavebeenassociatedwithalteredprotein

    functionandBERactivity.Thiscasc

    controlstudyexalninedtilecontribution()fthesetwopolymorphisms.alone ,

    andinconlbination.o1"ininteractionwithslnokillg,totileriskot'developinglungcancer.Weestimatedtileriskof

    lungcancerassociatedwiththesepolymorphislnsin1,000cascsand1,000cancer

    freecontrolsusinglogistic

    regressionmodels.SubjectshavingtileAD1'lu'Ala/Alagenotypehadanoddsratio(0R)of1.6895%confidence

    interval(95%CI),1.27

    2.23ICOlnparcdwiththoschavingtileVal/Valgenotypc.Agreaterthannmltiplicativejoint cflbctbctwcelltileAI)PR'I,polylnorphisnlandsmokingwas{}bscrved.l'heORs(95%C1)oftheA1a/Alagenotype

    '

f0rnonsnlokersandsnlokcrswhosmokedlCSSthanorequalto16,16to28,or>28pack

    yearswere1.13(0.791.62),

    1.35(0.68-2.70),2.46(1.354.51)or17.09(8.1535.83),respcctively(1

    trendtest<0.001).Gencgeneinteractionof

    ADPR'I'andXRCC1pobanorphismsincreasedriskoflungcancerinasupennultiplicativemannerfORforlhepresence

    ofboth1)l'R'l'762Ala/AlaandXRCC1399GllVGlngenotyt~zs,5.91;95%C1,2.09

    16.72),althoutileXRCC1poly-

    nlorphisnlitselfwasnotassociatedwiththel'isk_InconclusiontheAI)I'RTVal762Alatx}lym{}rplfisnlplaysanimportant

    roleinsm(1king

    relatedlungCallCCl'andtheXRCC1Arg399(}lnpolymorphismmayserveasariskmodifier.

    l5

Keyw0rSQUAMOUS

    CELLCARCINOMA;CHINESEPOPULATION;POLY(ADP-RIBOSE)POLYMERAS

    E;

    ASSOCIAT'IoNs;VARIANTS;XPD;SUSCEPTIBILITY;FREQUENCY;D?~VIAGE'.0'

    CANCERRESEARCH2005,653l:722726

    LackofevidenceforamajorgeneintheMendeliantransmissionofBMIin Chinese

    LiuPY,LiYM,LiMX,Mal~nI,QinYJ,ChenXD,LiuYJ,DengHW

    CreightonUniv,MedCtr,OsteoporosisResCtr,Omaha,NE68l3lUSA

    HunallNormalUniv,CoilLifeSci,LabMol&StatGenet,Hunan,PeoplesRChina TelAvivUniv,SacklerFacMed,DeptAnat&Anthropol,HumanPopularBiolResUnit;TelAviv,儿一69978Israel

    ShanghaiSixthPeoplesHosp,CtrPrevent&TreatingOsteoporosis,Shanghai,PeoplesRChina

HuaihHaUniV,DeptMath,Hunan,PeoplesRChina

    Abstract:0bjectives:TodeterminetheheritabilityofBMIandtoexaminethemodeofinheritanceofBMIvariation

    inChinese.

    ResearchMethodsandProcedures:FamilialcorrelationandcomplexsegregationanalysesforBM1wereunder

    takeninaChinesesamplecomposedof392nuclearfamilies,with1190totalindividuals. Results:AmoderateheritabilitywasfoundforBMI(h(2)=O.419-0.492).Theobtainedresultsdonotsupport

    amajorgeneforBMIinoursamples.BMImaybeinheritedinacomplexandnon

    MendelianmannerinChinese.

    Discussion:ThefindingsofthisstudysuggestthatidentificationofspecificgenesforBMIinChinese,atleast

    withinthesamedataset,isaseriouschallengebecauseofthelackofevidenceofamajorgeneforBMIinour

    Chinesesample.

    Keywords:BMI;Chinesepopulation;familialcorrelation;segregationanalysis;majorgenes

    OBESITYRESEARCH2004.12l2l:1967l973

    Atherapeuticstrategyuseshistonedeacetylaseinhibitorstomodulatethe expressionofgenesinvolvedinthepathogenesisofrheumatoidarthritis ChungYL,LeeMWangAJ,YaoLF

    KooFdn,SunYatSenCancCtr,DeptRadiatOncol,Taipei,112Taiwan~'China KooFdn,SunYatSenCancCtr,DeptPathol,Taipei,112Taiwan~'China

    lndTechnolReslnst,CtrBiochemEngn,DrugDeliveryDept,Hsinchu,300Taiwan~'China NatlYangMingUniv,SchMed,Taipei,ll2Taiwan~'China

    Abstract:Rheumatoidarthritis(RA)ischaracterizedbyprogressivedestructionoftheaffectedjoints.Thepatho

    

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