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Wolfs Amnesia

By Paula Elliott,2014-06-26 21:48
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Wolfs Amnesia ...

    Wolf’s Amnesia A transient selective loss of memory during an exam that prevents one

    from remembering the eponymically-named diseases discovered by old, dead doctors.

    ??primary adrenocortical deficiency Addison’s Disease

    ??pernicious anemia (antibodies to intrinsic factor or parietal cells ? ?IF ? ?Vit B ? megaloblastic anemia) 12Addisonian Anemia

    ??polyostotic fibrous dysplasia, precocious puberty, café au lait spots, short stature, young girls Albright’s Syndrome

    ??hereditary nephritis with nerve deafness Alport’s Syndrome

    ??progressive dementia Alzheimer’s

    ??loss of light reflex constriction (contralateral or bilateral) Argyll-Robertson Pupil ??“Prostitute’s Eye” - accommodates but does not react ??Pathognomonic for 3?Syphilis ??cerebellar tonsil herniation Arnold-Chiari Malformation

    ??columnar metaplasia of lower esophagus (? risk of adenocarcinoma) Barrett’s

    ??hyperreninemia Bartter’s Syndrome

    ??similar to Duchenne, but less severe (deficiency in dystrophin protein) Becker’s Muscular Dystrophy

    ??CNVII palsy (entire face; recall that UMN lesion only affects lower face) Bell’s Palsy

    ??IgA nephropathy Berger’s Disease

    ??defect in platelet adhesion (abnormally large platelets & lack of platelet-surface glycoprotein) Bernard-Soulier Disease

    ??circle of Willis (subarachnoid bleed) Berry Aneurysm ??often associated with ADPKD ??carcinoma in situ on shaft of penis (? risk of visceral ca) Bowen’s Disease

    ??somatization disorder Briquet’s Syndrome ??psychological: multiple physical complaints without physical pathology

    ??Motor Aphasia intact comprehension Broca’s Aphasia

    ??hemisection of cord (contralateral loss of pain & temp / ipsilateral loss of fine touch, UMN) Brown-Sequard

    ??X-linked agammaglobinemia Bruton’s Disease

    ??post-hepatic venous thrombosis Budd-Chiari

    ??acute inflammation of small, medium arteries ? painful ischemia ? gangrene Buerger’s Disease

    ??small noncleaved cell lymphoma EBV Burkitt’s Lymphoma ??8:14 translocation

    ??gas emboli Caisson Disease

    ??Trypansoma infection sleeping disease, cardiomegaly with apical atrophy, achlasia Chagas’ Disease

    ??Phagocyte Deficiency: neutropenia, albinism, cranial & peripheral neuropathy Chediak-Higashi Disease ??repeated infections

    ??primary aldosteronism Conn’s Syndrome

    ??glycogen storage disease (debranching enzyme deficiency) Cori’s Disease

    ??prion infection ? cerebellar & cerebral degeneration Creutzfeldt-Jakob

    ??congenital hyperbilirubinemia (unconjugated) Crigler-Najjar Syndrome ??glucuronyl transferase deficiency ??IBD; ileocecum, transmural, skip lesions, lymphocytic infiltrate, granulomas Crohn’s (contrast to UC: limited to colon, mucosa & submucosa, crypt abscesses, pseudopolyps, ? colon cancer risk)

    ??acute gastric ulcer associated with severe burns Curling’s Ulcer

    ??Disease: hypercorticism 2? to ? ACTH from pituitary (basophilic adenoma) Cushing’s ??Syndrome: hypercorticism of all other causes (1? adrenal or ectopic)

    ??acute gastric ulcer associated with CNS trauma Cushing’s Ulcer

    ??self-limiting focal destruction (subacute thyroiditis) de Quervain’s Thyroiditis

    ??thymic hypoplasia ? T-cell deficiency DiGeorge’s Syndrome ??hypoparathyroidism

    ??trisomy 21 or translocation Down’s Syndrome

    ??Post-MI Fibrinous Pericarditis autoimmune Dressler’s Syndrome

    ??congenital hyperbilirubinemia (conjugated) Dubin-Johnson Syndrome ??striking brown-to-black discoloration of the liver

    ??deficiency of dystrophin protein ? MD X-linked recessive Duchenne Muscular Dystrophy

    ??trisomy 18 Edwards’ Syndrome ??rocker-bottom feet, low ears, heart disease

    Milton Wolf Page 1 of 9 06/26/10

??defective collagen Ehler’s-Danlos

    ??late cyanotic shunt (R?L) pulmonary HTN & RVH 2? to long-standing VSD, ASD, or PDA Eisenmenger’s Complex

    ??trauma to superior trunk of brachial plexus Waiter’s Tip Erb-Duchenne Palsy

    ??undifferentiated round cell tumor of bone Ewing Sarcoma

    ??carcinoma in situ on glans penis Eyrthroplasia of Queyrat

    ??impaired proximal tubular reabsorption 2? to lead poisoning or Tetracycline (glycosuria, hyperphosphaturia, Fanconi’s Syndrome aminoaciduria, systemic acidosis)

    ??rheumatoid arthritis, neutropenia, splenomegaly Felty’s Syndrome

    ??adenomatous polyps of colon plus osteomas & soft tissue tumors Gardner’s Syndrome

    ??Lysosomal Storage Disease glucocerebrosidase deficiency Gaucher’s Disease ??hepatosplenomegaly, femoral head & long bone erosion, anemia

    ??benign congenital hyperbilirubinemia (unconjugated) Gilbert’s Syndrome

    ??defective glycoproteins on platelets Glanzmann's Thrombasthenia

    ??autoimmune: ab’s to glomerular & alveolar basement membranes Goodpasture’s

    ??autoimmune hyperthyroidism (TSI) Grave’s Disease

    ??idiopathic polyneuritis (ascending muscle weakness & paralysis; usually self-limiting) Guillain-Barre

    ??idiopathic pulmonary fibrosis Hamman-Rich Syndrome

    ??chronic progressive histiocytosis Hand-Schuller-Christian

    ??autoimmune hypothyroidism Hashimoto’s Thyroiditis

    ??initial hyperthyroidism in Hashimoto’s Thyroiditis that precedes hypothyroidism Hashitoxicosis

    ??hypersensivity vasculitis Henoch-Schonlein purpura ??hemmorhagic urticaria (with fever, arthralgias, GI & renal involvement) ??associated with upper respiratory infections

    ??aganglionic megacolon Hirschprung’s Disease

    ??ptosis, miosis, anhidrosis (lesion of cervical sympathetic nerves often 2? to a Pancoast tumor) Horner’s Syndrome

    ??progressive degeneration of caudate nucleus, putamen & frontal cortex; AD Huntington’s

    ??epileptic events originating in the primary motor cortex (area 4) Jacksonian Seizures

    ??immune deficiency: neutrophils fail to respond to chemotactic stimuli Job’s Syndrome

    ??malignant vascular tumor (HHV8 in homosexual men) Kaposi Sarcoma

    ??immotile cilia 2? to defective dynein arms infection, situs inversus, sterility Kartagener’s Syndrome

    ??mucocutaneous lymph node syndrome (lips, oral mucosa) Kawasaki Disease

    ??47, XXY Klinefelter’s Syndrome

    ??bilateral lesions of amygdala (hypersexuality; oral behavior) Kluver-Bucy

    ??adenocarcinoma with signet-ring cells (typically originating from the stomach) metastases to the Krukenberg Tumor ovaries

    ??alcoholic cirrhosis Laennec’s Cirrhosis

    ??HGPRT deficiency Lesch-Nyhan ??gout, retardation, self-mutilation

    ??acute disseminated Langerhans’ cell histiocytosis Letterer-Siwe

    ??endocarditis with small vegetations on valve leaflets Libman-Sacks ??associated with SLE ??Amyotrophic Lateral Sclerosis degeneration of upper & lower motor neurons Lou Gehrig’s

    ??bleeding from esophagogastric lacerations 2? to wretching (alcoholics) Mallory-Weis Syndrome

    ??connective tissue defect Marfan’s

    ??glycogen storage disease (muscle phosphorylase deficiency) McArdle’s Disease

    ??rule of 2’s: 2 inches long, 2 feet from the ileocecum, in 2% of the population Meckel’s Diverticulum ??embryonic duct origin; may contain ectopic tissue (gastric, pancreatic, etc.)

    ??Triad: ovarian fibroma, ascites, hydrothorax Meig’s Syndrome

    ??giant hypertrophic gastritis (enlarged rugae; plasma protein loss) Menetrier’s Disease

    ??calcification of the media (usually radial & ulnar aa.) Monckeberg’s Arteriosclerosis

    ??factitious disorder (consciously creates symptoms, but doesn’t know why) Munchausen Syndrome

    ??1? Adrenal Cushings ? surgical removal of adrenals ? loss of negative feedback to pituitary ? Nelson’s Syndrome Pituitary Adenoma ??Lysosomal Storage Disease sphingomyelinase deficiency Niemann-Pick ??“foamy histiocytes”

    Milton Wolf Page 2 of 9 06/26/10

??Hereditary Hemorrhagic Telangiectasia Osler-Weber-Rendu Syndrome

    ??abnormal bone architecture (thickened, numerous fractures ? pain) Paget’s Disease

    ??bronchogenic tumor with superior sulcus involvement ? Horner’s Syndrome Pancoast Tumor

    ??dopamine depletion in nigrostriatal tracts Parkinson’s

    ??melanin pigmentation of lips, mouth, hand, genitalia plus hamartomatous polyps of small intestine Peutz-Jegher’s Syndrome

    ??subcutaneous fibrosis of dorsum of penis Peyronie’s Disease

    ??progressive dementia similar to Alzheimer’s Pick’s Disease

    ??hyperthyroidism, nodular goiter, absence of eye signs (Plummer’s = Grave’s - eye signs) Plummer’s Syndrome

    ??esophageal webs & iron-deficiency anemia, ? SCCA of esophagus Plummer-Vinson

    ??glycogen storage disease ? cardiomegaly Pompe’s Disease

    ??tuberculous osteomyelitis of the vertebrae Pott’s Disease

    ??renal agenesis ? oligohydramnios ? hypoplastic lungs, defects in extremities Potter’s Complex

    ??Disease: recurrent vasospasm in extremities Raynaud’s ??Phenomenon: 2? to underlying disease (SLE or scleroderma)

    ??urethritis, conjunctivitis, arthritis non-infectious (but often follows infections), HLA-B27, polyarticular Reiter’s Syndrome

    ??microvesicular fatty liver change & encephalopathy Reye’s Syndrome ??2? to aspirin ingestion in children following viral illness

    ??idiopathic fibrous replacement of thyroid Riedel’s Thyroiditis

    ??congenital hyperbilirubinemia (conjugated) Rotor Syndrome ??similar to Dubin-Johnson, but no discoloration of the liver

    ??leukemic form of cutaneous T-cell lymphoma (mycosis fungoides) Sezary Syndrome

    ??aluminum inhalation ? lung fibrosis Shaver’s Disease

    ??postpartum pituitary necrosis Sheehan’s Syndrome

    ??parkinsonism with autonomic dysfunction & orthostatic hypotension Shy-Drager

    ??pituitary cachexia Simmond’s Disease

    ??MEN type IIa (pheochromocytoma, thyroid medulla, parathyroid) Sipple’s Syndrome

    ??triad: dry eyes, dry mouth, arthritis ? risk of B-cell lymphoma Sjogren’s Syndrome

    ??juvenile melanoma (always benign) Spitz Nevus

    ??polycystic ovary Stein-Leventhal

    ??erythema multiforme, fever, malaise, mucosal ulceration (often 2? to infection or sulfa drugs) Stevens-Johnson Syndrome

    ??juvenile rheumatoid arthritis (absence of rheumatoid factor) Still’s Disease

    ??aortic arch syndrome Takayasu’s arteritis ??loss of carotid, radial or ulnar pulses

    ??gangliosidosis (hexosaminidase A deficiency ? G ganglioside) M2Tay-Sachs

    ???VSD, ?overriding aorta, ?pulmonary artery stenosis, ?right ventricular hypertrophy Tetralogy of Fallot

    ??involuntary actions, both motor and vocal Tourette’s Syndrome

    ??adenomatous polyps of colon plus CNS tumors Turcot’s Syndrome

    ??45, XO Turner’s Syndrome

    ??“trench mouth” - acute necrotizing ulcerative gingivitis Vincent’s Infection

    ??glycogen storage disease (G6Pase deficiency) von Gierke’s Disease

    ??hemangioma (or hemangioblastoma) von Hippel-Lindau ??adenomas of the viscera, especially renal cell carcinoma

    ??neurofibromatosis & café au lait spots von Recklinghausen’s

    ??osteitis fibrosa cystica (“brown tumor”) 2? to hyperparathyroidism von Recklinghausen’s Disease of Bone

    ??defect in platelet adhesion 2? to deficiency in vWF von Willebrand’s Disease

    ??proliferation of IgM-producing lymphoid cells Waldenstrom’s macroglobinemia

    ??Posterior Inferior Cerebellar Artery (PICA) thrombosis “Medullary Syndrome” Wallenberg’s Syndrome ??Ipsilateral: ataxia, facial pain & temp; Contralateral: body pain & temp

    ??catastrophic adrenal insufficiency 2? to hemorrhagic necrosis (eg, DIC) Waterhouse-Friderichsen ??often 2? to meningiococcemia

    ??Paramedian Infarct of Midbrain Weber’s Syndrome ??Ipsilateral: mydriasis; Contralateral: UMN paralysis (lower face & body)

    ??necrotizing granulomatous vasculitis of paranasal sinuses, lungs, kidneys, etc. Wegener’s Granulomatosis

    ??leptospirosis Weil’s Disease

    ??MEN type I (thyroid, parathyroid, adrenal cortex, pancreatic islets, pituitary) Wermer’s Syndrome

    Milton Wolf Page 3 of 9 06/26/10

??Sensory Aphasia impaired comprehension Wernicke’s Aphasia

    ??thiamine deficiency in alcoholics; bilateral mamillary bodies (confusion, ataxia, ophthalmoplegia) Wernicke-Korsakoff Syndrome

    ??malabsorption syndrome (with bacteria-laden macrophages) & polyarthritis Whipple’s Disease

    ??hepatolenticular degeneration (copper accumulation & decrease in ceruloplasmin) Wilson’s Disease

    ??immunodeficiency: combined B- &T-cell deficiency (thrombocytopenia & eczema) Wiskott-Aldrich Syndrome

    ??high iodine level (?)’s thyroid hormone synthesis Wolff-Chaikoff Effect

    ??esophageal; cricopharyngeal muscles above UES Zenker’s Diverticulum

    ??gastrin-secreting tumor of pancreas (or intestine) ? ? acid ? intractable ulcers Zollinger-Ellison

    Hallmark Findings

    ??Guillain-Barre (markedly increased protein in CSF with only modest increase in cell count) Albumino-Cytologic Dissociation

    ??idiopathic thrombocytopenic purpura Antiplatelet Antibodies

    ??Marfan’s Arachnodactyly

    ??rheumatic fever Aschoff Bodies

    ??acute promyelocytic leukemia (AML type M) 3Auer Rods

    ??sickle cell anemia Autosplenectomy

    ??UMN lesion Babinski

    ??lead poisoning Basophilic Stippling of RBCs

    ??multiple myeloma free light chains (either kappa or lambda) Bence Jones Protein ??Waldenstrom’s macroglobinemia

    ??histiocytosis X (eosinophilic granuloma) Birbeck Granules

    ??Chronic Bronchitis Blue Bloater

    ??Tetralogy of Fallot Boot-Shaped Heart

    ??osteoarthritis (PIP) Bouchard’s Nodes

    ??rheumatoid arthritis Boutonniere’s Deformity

    ??hyperparathyroidism Brown Tumor

    ??Down’s Brushfield Spots

    ??granulosa cell tumor Call-Exner Bodies

    ??Chagas’ Disease Cardiomegaly with Apical Atrophy

    ??1? Syphilis Chancre

    ??Haemophilus ducreyi Chancroid

    ??multiple sclerosis (nystagmus, intention tremor, scanning speech) Charcot Triad

    ??bronchial asthma Charcot-Leyden Crystals

    ??cerebral lesion Cheyne-Stokes Breathing

    ??endometriosis Chocolate Cysts

    ??Hypocalcemia facial spasm in tetany Chvostek’s Sign

    ??Gardnerella vaginitis Clue Cells

    ??osteosarcoma Codman’s Triangle

    ??Mycoplasma pneumoniae Cold Agglutinins ??infectious mononucleosis

    ??2? Syphilis Condyloma Lata ??new coffee flavor at Bagel & Bagel

    ??HTN Cotton Wool Spots

    ??dying hepatocytes Councilman Bodies

    ??rapidly progressive (crescentic glomerulonephritis) Crescents In Bowman’s Capsule

    ??Klebsiella Currant-Jelly Sputum

    ??bronchial asthma Curschmann’s Spirals

    ??Parkinson’s Depigmentation Of Substantia Nigra

    ??granuloma inguinale (STD) Donovan Bodies

    ??osteoarthritis (polished, ivory-like appearance of bone) Eburnation

    ??Marfan’s Ectopia Lentis

    ??Lyme Disease Erythema Chronicum Migrans

    ??Alcoholism Fatty Liver

    Milton Wolf Page 4 of 9 06/26/10

??asbestosis Ferruginous Bodies

    ??Tuberculosis (1? & 2?, respectively) Ghon Focus / Complex

    ??Duchenne’s MD use of arms to stand Gower’s Maneuver

    ??Osteoarthritis (DIP) Heberden’s Nodes

    ??G6PDH Deficiency Heinz Bodies

    ??Henoch-Schonlein Hemorrhagic Urticaria

    ??infectious mononucleosis (EBV) Heterophil Antibodies

    ??Alzheimer’s Hirano Bodies

    ??Megaloblastic anemia Hypersegmented PMNs

    ??iron-deficiency anemia Hypochromic Microcytic RBCs

    ??Syphilis over-aggressive treatment of an asymptomatic pt. that causes symptoms 2? to rapid lysis Jarisch-Herxheimer Reaction

    ??osteoarthritis (fractured osteophytes) Joint Mice

    ??acidosis Kaussmaul Breathing

    ??SCCA Keratin Pearls

    ??Wilson’s Keyser-Fleischer Ring

    ??diabetic nephropathy Kimmelstiel-Wilson Nodules

    ??HPV Koilocytes

    ??measles Koplik Spots

    ??Parkinson’s (eosinophilic inclusions in damaged substantia nigra cells) Lewy Bodies

    ??arterial thrombus Lines of Zahn

    ??neurofibromatosis (von Recklinhausen’s disease) Lisch Nodules

    ??poststreptococcal glomerulonephritis Lumpy-Bumpy IF Glomeruli

    ??appendicitis (McBurney’s Point is 2/3 of the way from the umbilicus to anterior superior iliac spine) McBurney’s Sign

    ??Malakoplakia Michealis-Gutmann Bodies

    ??multiple myeloma this is called the M protein (usually IgG or IgA) Monoclonal Antibody Spike ??MGUS

    ??hypothyroidism Myxedema

    ??rabies Negri Bodies

    ??Alzheimer’s Neuritic Plaques

    ??Alzheimer’s Neurofibrillary Tangles

    ??Myxedema Non-pitting Edema ??Anthrax Toxin

    ??Coarctation of Aorta Notching of Ribs

    ??CHF Nutmeg Liver

    ??pancreatic CA (head) Painless Jaundice

    ??rheumatoid arthritis Pannus

    ??mycosis fungoides (cutaneous T-cell lymphoma) Pautrier’s Microabscesses

    ??CML Philadelphia Chromosome ??ALL

    ??Pick’s Disease Pick Bodies

    ??Emphysema Centroacinar smoking Panacinar - ?-antitrypsin deficiency 1Pink Puffer

    ??gout (MP joint of hallux) Podagra

    ??Hemangioma Port-Wine Stain

    ??tearing of the ACL Posterior Anterior Drawer Sign

    ??Papillary adenocarcinoma of the thyroid Psammoma Bodies ??Serous papillary cystadenocarcinoma of the ovary ??Meningioma ??Mesothelioma

    ??Duchenne muscular dystrophy Pseudohypertrophy

    ??multiple myeloma Punched-Out Bone Lesions

    ??2? Syphilis Rash on Palms & Soles ??RMSF

    ??paroxysmal nocturnal hemoglobinuria Red Morning Urine

    ??Hodgkin’s Disease Reed-Sternberg Cells

    Milton Wolf Page 5 of 9 06/26/10

??chronic bronchitis Reid Index Increased

    ??Leydig cell tumor Reinke Crystals

    ??multiple myeloma RBC’s stacked as poker chips Rouleaux Formation

    ??L?R Shunt (VSD, PDA) S3 Heart Sound ??Mitral Regurg ??LV Failure

    ??Pulmonary Stenosis S4 Heart Sound ??Pulmonary HTN

    ??Neisseria meningitidis impressive rash with bugs Schwartzman Reaction

    ??Down’s Simian Crease

    ??SLE (also anti-dsDNA) Smith Antigen

    ??giant cell tumor of bone Soap Bubble on X-Ray

    ??membranous glomerulonephritis Spike & Dome Glomeruli

    ??Crohn’s bowel wall thickening String Sign on X-ray

    ??Thalassemia Target Cells

    ??Familial Hypercholesterolemia Tendinous Xanthomas

    ??chronic pyelonephritis Thyroidization of Kidney

    ??gout Tophi

    ??membranoproliferative glomerulonephritis Tram-Track Glomeruli

    ??visceral ca, classically pancreatic (migratory thrombophlebitis) Trousseau’s Sign ??hypocalcemia (carpal spasm)

    These are two entirely different disease processes and different signs, but they unfortunately have the same name.

    ??supraclavicular node enlargement by metastatic carcinoma of the stomach Virchow’s Node

    ??Measles Warthin-Finkeldey Giant Cells

    ??pyelonephritis WBC Casts

    ??lupus nephropathy, type IV Wire Loop Glomeruli

    ??Spina Bifida ? AFP in amniotic fluid or mother’s ??Anencephaly serum

    ??Gout ? Uric Acid ??Lesch Nyhan ??Myeloproliferative Disorders ??Diuretics (Loop & Thiazides)

    ??COPD ? FEV/FVC 1

    Most Common…

    ??Multiple Myeloma 1? Tumor arising from bone in adults

    ??Pheochromocytoma Adrenal Medullary Tumor Adults

    ??Neuroblastoma Adrenal Medullary Tumor Children

    ??Neisseria meningitidis Bacterial Meningitis adults

    ??Strep pneumoniae Bacterial Meningitis elderly

    ??E. coli Bacterial Meningitis newborns

    ??Hib Bacterial Meningitis toddlers

    ??Metasteses from Breast & Prostate Bone Tumors

    ??Medulloblastoma (cerebellum) Brain Tumor Child

    ??Astrocytoma (including Glioblastoma Multiforme) then: mets, meningioma, Schwannoma Brain Tumor Adult

    ??Invasive Duct Carcinoma Breast Carcinoma

    ??Fibrocystic Change (Carcinoma is the most common is post-menopausal women) Breast Mass

    ??Staph aureus Bug in Acute Endocarditis

    ??Klebsiella Bug in debilitated, hospitalized pneumonia pt

    ??Hib Bug in Epiglottitis nd??Bacteroides (2 E. coli) Bug in GI Tract

    ??Staph aureus Bug in IV drug user bacteremia / pneumonia

    ??N. Gonnorrhoeae Bug in PID

    Milton Wolf Page 6 of 9 06/26/10

??Strep Viridans Bug in Subacute Endocarditis

    ??Myxoma “Ball Valve” Cardiac 1? Tumor Adults

    ??Rhabdomyoma Cardiac 1? Tumor Child

    ??Metasteses Cardiac Tumor Adults

    ??Dilated (Congestive) Cardiomyopathy Cardiomyopathy

    ??Renal Disease Cause of 2? HTN nd??Autoimmune (2 infection) Cause of Addison’s

    ??21-Hydroxylase Deficiency (then, 11-) Cause of Congenital Adrenal Hyperplasia

    ??Exogenous Steroid Therapy (then, 1? ? ACTH, Adrenal Adenoma, Ectopic ACTH) Cause of Cushings

    ??Pneumonia Cause of death in Alzheimer pts

    ??MI Cause of death in Diabetics

    ??Lupus Nephropathy Type IV (Diffuse Proliferative) Cause of Death in SLE pts.

    ??Alzheimer’s Cause of Dementia

    nd??Multi-Infarct Dementia Cause of Dementia (2 most common)

    ??Staph aureus Cause of food poisoning

    ??Down’s Cause of mental retardation

    nd??Fragile X Cause of mental retardation (2 most common)

    ??Chlamydia Cause of preventable blindness

    ??COPD Cause of Pulmonary HTN

    ??Small Cell Carcinoma of the Lung Cause of SIADH

    ??Down’s Chromosomal disorder

    ??VSD (membranous > muscular) Congenital cardiac anomaly

    ??Tetralogy of Fallot Congenital early cyanosis

    ??LAD Coronary Artery thrombosis

    ??Multiple Sclerosis Demyelinating Disease

    ??Iron Dietary Deficiency

    ??CMV (Pneumocystis carinii is most common overall) Disseminated opportunistic infection in AIDS

    ??SCCA Esophageal cancer

    ??Cystic Fibrosis Fatal genetic defect in Caucasians

    ??Leimyoma Female Tumor

    ??Immunologic (Bence Jones protein in multiple myeloma is also called the Amyloid Light Chain) Form of Amyloidosis

    ??Ulceroglandular Form of Tularemia

    ??Endometrial Carcinoma Gynecologic malignancy

    ??Mitral Valve Prolapse Heart Murmur

    ??Mitral Heart Valve in bacterial endocarditis

    ??Tricuspid Heart Valve in bacterial endocarditis in IV drug users

    ??Mitral then Aortic Heart Valve involved in Rheumatic Fever

    ??Von Willebrand’s Disease Hereditary Bleeding Disorder

    ??Hepatoma Liver 1? Tumor

    ??Alcoholic Liver Disease Liver Disease

    ??Above Tentorium Location of Adult brain tumors

    ??Below Tentorium Location of Childhood brain tumors

    ??Gaucher’s Lysosomal Storage Disease

    ??ALS Motor Neuron Disease

    ??Leukemia Neoplasm Child

    nd??Medulloblastoma of brain (cerebellum) Neoplasm Child (2 most common)

    ??Membranous Glomerulonephritis Nephrotic Syndrome

    ??PCP Opportunistic infection in AIDS

    ??Serous Cystadenoma Ovarian Malignancy

    ??Hamartoma Ovarian Tumor

    ??Adeno (usually in the head) Pancreatic Tumor

    ??ALL - Child / CLL - Adult over 60 / AML - Adult over 60 / CML - Adult 35-50 Patient with ALL / CLL / AML / CML

    Milton Wolf Page 7 of 9 06/26/10

    ??Young male Patient with Goodpasture’s

    ??Male Patient with Reiter’s nd??Prolactinoma (2 Somatotropic “Acidophilic” Adenoma) Pituitary Tumor

    ??Adenomas (followed by: hyperplasia, then carcinoma) Primary Hyperparathyroidism

    ??Young Male (except Nodular Sclerosis type Female) Pt. With Hodgkin’s

    ??Young Child Pt. With Minimal Change Disease

    ??Hypocalcemia of Chronic Renal Failure Secondary Hyperparathyroidism

    ??Chlamydia Sexually transmitted disease

    ??Sigmoid Colon Site of Diverticula

    ??Regional Lymph Nodes Site of metastasis

    nd??Liver Site of metastasis (2 most common)

    ??Abdominal aorta > coronary > popliteal > carotid Sites of atherosclerosis

    ??Basal Cell Carcinoma Skin Cancer

    ??Adeno Stomach cancer

    ??Seminoma Testicular Tumor

    ??Papillary Carcinoma Thyroid Cancer

    ??Lower esophagus joins trachea / upper esophagus blind pouch Tracheoesophageal Fistula

    ??Hemangioma Tumor of Infancy

    ??Mixed Cellularity (versus: lymphocytic predominance, lymphocytic depletion, nodular sclerosis) Type of Hodkin’s

    ??Follicular, small cleaved Type of Non-Hodgkin’s

    ??Temporal Arteritis Vasculitis (of medium & small arteries)

    ??HSV Viral Encephalitis nd??Pinworm (2 Ascaris) Worm infection in US

    Signature Drug Toxicities

    ??Clozapine Agranulocytosis

    ??Chloramphenicol Aplastic Anemia ??NSAIDs ??Benzene

    ??Tricyclics Atropine-like Side Effects

    ??Doxorubicin Cardiotoxicity ??Daunorubicin

    ??Fluoroquinolones (Ciprofloxacin & Norfloxacin) Cartilage Damage in children

    ??Quinidine Cinchonism

    ??ACE Inhibitors Cough

    ??Lithium Diabetes Insipidus

    ??Metronidazole Disulfiram-like effect st??Sulfonylureas (1 generation)

    ??Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine) Extrapyramidal Side Effects

    ??Tetracycline Fanconi’s Syndrome

    ??Valproic Acid Fatal Hepatotoxicity (necrosis) ??Halothane ??Acetaminophen

    ??Phenytoin Gingical Hyperplasia

    ??Chloramphenicol Gray Baby Syndrome

    ??Cimetidine Gynecomastia ??Azoles ??Spironolactone ??Digitalis

    ??Sulfonamides Hemolytic Anemia in G6PD-deficiency ??Isoniazid ??Aspirin ??Ibuprofen ??Primaquine

    Milton Wolf Page 8 of 9 06/26/10

    ??Isoniazid Hepatitis

    ??Niacin Hot Flashes, Flushing ??Tamoxifen ++??Ca Channel Blockers

    ??Barbiturates Induce CP450 ??Phenytoin ??Carbamazepine ??Rifampin

    ??Cimetidine Inhibit CP450 ??Ketoconazole

    ??Methicillin Interstitial Nephritis ??NSAIDs (except Aspirin) ??Furosemide ??Sulfonamides

    ??Nitroglycerin Industrial exposure ? tolerance during week ? loss of tolerance during weekend ? headache, Monday Disease tach, dizziness upon re-exposure

    ??Rifampin Orange Body Fluids

    ??Heparin Osteoporosis ??Corticosteroids

    ??Methyldopa Positive Coombs’ Test

    ??Bleomycin Pulmonary Fibrosis ??Amiodarone

    ??Vancomycin Red Man Syndrome

    ??MAOIs Severe HTN with Tyramine

    ??Procainamide SLE-like Syndrome ??Hydralazine

    ??Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine) Tardive Dyskinesia

    ??Aspirin Tinnitus ??Quinidine

Miscellaneous

    ? Fastest growing tumor Burkitt’s

    ? PE’s are found in half of all autopsies

    ? Courvoisier’s Law: tumors that obstruct the common bile duct cause enlarged gallbladders, but obstructing

    gallstones do not (too much scarring).

    ? Only DNA virus to replicate in cytoplasm: Pox

    ? Only RNA virus to replicate in nucleus: Influenza

    ? Bacillus anthracis has the only protein capsule

    ? Bordetella pertussis (Whooping Cough) elicits lymphocytosis rather than granulocytosis

    ? Bronchioalveolar carcinomas grow without destroying the normal architecture of the lung

    ? Cryptococcus neoformans often lacks a capsule and, when stained with GMS, looks just like Pneumycistis

    carinii, except that Cryptococcus lacks the prominent nucleoli.

    Milton Wolf Page 9 of 9 06/26/10

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