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BINF 7210: STATISTICAL METHODS IN BIOINFORMATICS

By Brenda Rogers,2014-10-29 16:31
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The objective of this course is the development and application of statistical methods used in bioinformatics. The topics will include analysis of one DNA Sequence, modeling DNA, shotgun sequencing modeling, analysis of patterns (Overlaps counted and not counted), profiles and multiple alignments.

    BINF 7210 STATISTICAL METHODS IN BIOINFORMATIC

    Course Learning Objectives

    The student will be able to

    1. Describe concepts and principles of probability theory 2. Explain the Binomial and Poisson Processes

    3. Describe and compute probability generating functions 4. Describe the shotgun sequencing technique

    5. Explain modeling signals in DNA

    6. Describe and analyze patterns in DNA sequences

    7. Select and apply appropriate methodologies for frequency comparisons of

    two DNA Sequences

    8. Perform statistical tests for similarity in alignment of sequences 9. Describe concepts and principles of protein sequences and substitution matrix 10. Describe and evaluate BLOSUM substitution matrix

    11. Apply the PAM substitution matrix for analyzing protein sequences. 12. Describe the concept of molecular evolution

    13. Develop models for estimating evolutionary distances from aligned sequence 14. Describe and evaluate phylogenetic analysis

    15. Evaluate the Fitch-Margoliash method

    16. Assess the Neighbor-Joining method

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