Combination of Chinese and Western medicine treatment of type 2 diabetes mellitus

     【Abstract】 Objective To study the combined Chinese and Western medicine to treat diabetes ideal way to observe the traditional Chinese medicine combined Yiqiyangyin glimepiride

    treatment of diabetes clinical effect. Methods Prostisol, promoting blood circulation Huayu Chinese herbs glimepiride treatment of type 2 diabetes mellitus (T2DM) patients with 57 cases, and with simple oral medicine glimepiride group

    compared 54 patients, 6-month course of treatment are to

    observe the blood glucose and the change in glycated hemoglobin. Results between the two groups 1,3,6 months after the change in blood glucose and glycated hemoglobin difference was not statistically significant. 30,60,90 d after stopping to change the blood glucose and glycated hemoglobin significantly statistically significant. Conclusions combination of Chinese and Western medicine to treat diabetes long-term effect is better than Western medicine hypoglycemic

    therapy, but similar short-term effect.

     Key words Type 2 diabetes, blood circulation Huayu Qi Yin combination therapy Glimepiride

     Type 2 diabetes mellitus (T2DM) Western Multi-promoting

    islet β-cell secretion of drugs such as sulfonylureas or

    insulin therapy, the recent significant hypoglycemic effect, but there is increasing very quickly after stopping glucose or secondary failure of sulfonylureas shortcomings, is far phase effect less than expected. The author since 2000, with the Qi

    Yin, promoting blood circulation Huayu Chinese herbs glimepiride treatment of T2DM, long-term efficacy is superior

    to western medicine alone. Are reported below.

     A clinical data

     1.1 The diagnostic criteria for all diabetic patients

    were hospital patients, in line with 1999 WHO diagnostic criteria established T2DM [1].

     1.2 Case selection and treatment group, 57 cases excluded: 33 cases of male and female 24 cases; aged 37 to 69 years, mean 55.7 years; fasting blood glucose (FBG) 8.6 ~ 15.3

    mmol / L, glycosylated hemoglobin (HbA1C) 7.70 ~ 11.67 g / L, diabetes duration of 3 to 17.8 years, with diabetic nephropathy, diabetic retinopathy, coronary heart disease in 15 cases. Control group, 54 cases: 32 cases of male and female 22 cases; age of 37.5 ~ 68.8 years, mean 55.9 years; FBG 8.5 ~ 15.80 mmol / L, HbA1C 8.00 ~ 11.58 g / L, diabetes duration of 2.8 ~ 18.1 years, with diabetic nephropathy , diabetic retinopathy, coronary heart disease a total of 14 cases. Two groups of patients with sex, age, FBG, HbA1C, course,

    complications basically the same as comparable. The following selected cases of patients with omissions: ? primary or

    secondary sulfonylurea failure were, ? gestational diabetes,

    ? clinical symptoms after treatment were significantly

    heavier, ? with severe complications.

     Two treatment

     The original two groups of patients with physical therapy, diet therapy program remains unchanged, pre-treatment

    to stop all antidiabetic drugs 10 d, as a wash off stage, and

    then were treated in two ways.

     Treatment group: traditional Chinese medicine combined glimepiride treatment. Treatment principles: Qi Yin, promoting blood circulation Huayu; party election Shengmaisan All Yiqihuoxue Decoction. Medicinal: Ginseng 10 g, Radix Astragali

    30 g, Ophiopogon japonicus 20 g, Schisandra 15 g, Adenophora 20 g, TCS 20 g, Radix Paeoniae Rubra 15 g, earthworm 12 g, Chuanxiong 15 g. Modified: blood sugar does not drop reused ginseng, plus Zhimu; dizziness headache plus Gastrodia elata,

    Prunella vulgaris, Uncaria; upset insomnia plus Polygalaceae,

    iris; cold limbs plus cinnamon, Fuzi; diabetic retinopathy increases chrysanthemum, Eriocaulon; Diabetic Nephropathy add Fuling, yam. 1 / d, 15 d 1 course of treatment, rest 3 d,

    proceed to the next one course of treatment. At the same time before breakfast Leighton served Glimepiride tablets, the starting dose of 1mg, according to FBG levels, 1 to 2 weeks after the adjustment of dosage of glimepiride, adjust the target: FBG (7.0 ? 1.0) mmol / L, glimepiride maximum dosage of 8 mmg / d, Chaoguo 4 mg taken twice a day and night hours were treated for 6 months. Reposted elsewhere in the paper for free download http://

     Control group: a single treatment with glimepiride. Oral

    administration of glimepiride tablets (Glimepiride, Beijing Pharmaceutical Co., Ltd. Hokuriku production, trade names, Di North Diabell), initial dose of 1 mg, 1 times / d, before breakfast Dayton clothes, according to FBG levels, 1 to 2 weeks After the adjustment of dosage, adjusting the target: FBG (7.0 ? 1.0) mmol / L, glimepiride maximum dosage of 8 mmg / d, Chao Guo 4 mg twice a day and night hours using it, treatment with the former.

     3 Treatment outcome

     3.1 short-term effect in Table 1.

     3.2 Long-term effect in table 2. 10,30,60,90 d after treatment were assayed by FBG, HbA1C.

     Table 1 Comparison of two short-term effect (omitted)

     Comparison of short-term effect between the two groups, * P> 0.05

     Table 2 Comparison of two long-term effects (omitted)

     Comparison of two groups of long-term effect, * P <0.05

     4 Discussion

     Diabetes is a Chinese medicine, "Diabetes" category. Known as congenital deficiency, combined with emotional loss Shu, diet disloyal, exogenous pathogenic toxin, such as caused by too much room workers Qi and Yin Deficiency, congestion block, made of Diabetes. Diabetes course of time, loss Yin gas consumption, gas for the blood Shuai, gas line is the blood line, unable to transport the blood Er Zhi Qi stasis,

    congestion Serve to check the air machine, air-disorders,

    Mizutsu lost cloth, its thirst is even worse this disease there is always Qi and Yin Deficiency, congestion deter pathological changes, for the etiology and pathogenesis,

    Expelling Prostisol, promoting blood circulation Huayu. Fang ginseng, astragalus qi spleen; Ophiopogon, Schisandra, Adenophora, TCS Yin Shengjinzhike; TPG, Chuanxiong, angelica blood circulation Huayu; to Long pass through up to network. Combination of various drugs were played Prostisol, promoting blood circulation Huayu achievements. Modern pharmacological studies have shown that ginseng, astragalus can change the function of islet cell secretion of insulin to enhance tissue sensitivity to insulin and reduce insulin resistance [2]. Most patients with diabetes, the course of time there

    microcirculation, blood viscosity stasis, the blood was "hyperviscosity syndrome" performance, promoting blood circulation Huayu Chinese Herbs Radix Paeoniae Rubra,

    Chuanxiong, angelica have lower blood viscosity, increase anticoagulation and fiber solvent activity, improving microcirculation role.

     Assessment of diabetes, glycosylated hemoglobin changes are an important indicator of long-term efficacy, when the

    glycated hemoglobin below 7 g / L, all kinds of complications (cardiovascular disease, diabetic nephropathy, diabetic

    retinopathy, etc.) significantly reduced the incidence of diabetes Evaluation of hypoglycemic effect of not only look at the recent, but also look at long-term efficacy (glycated

    hemoglobin changes, sooner or later complications, severity,

    quality of life, etc.). Hypoglycemic range size, speed, speed does not mean efficacy, especially Chinese medicine treatment of diabetes effects, we should not simply increase the size determined from the hypoglycemic effect. Chinese medicine

    treatment of this disease is to make the overall function of the body to achieve balance, lower blood sugar regulating bodily functions is only part of it. I believe that combining Chinese and Western medicine prevention and treatment of diabetes and its complications is an ideal therapy, Western medicine to quickly lower the blood sugar may be short-term

    effect, traditional Chinese medicine from a multi-system,

    multi-level, multi-link, multi-target, all-round adjustment of

    yin and yang, qi and blood, thereby to treating the symptoms, reduce or delay complications and improve quality of life purposes.

     【References】

     [1] often had mishaps, high-Yan-bin, money autumn sea.

    TCM and Western medicine treatment of diabetes mellitus [M] Beijing: People's Health Press, 2002:7.

     [2] Weng Liang. Fang Shuting clinical pharmacy [M]. Zhengzhou: Henan Science and Technology Press, 2001:431. Reposted elsewhere in the paper for free download http://