Chuanmutong Research Progress_777

By Phyllis Willis,2014-10-30 13:09
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Chuanmutong Research Progress_777

Chuanmutong Research Progress

     Abstract Chuanmutong Textual research in recent years, resource status, chemical composition, quality evaluation and pharmacological aspects of the role of research are reviewed for their further study and application provide a more

    comprehensive introduction.

     Key words Chuanmutong Textual Research Resources in the quality evaluation of Pharmacological Science ingredients

     Progress on Studies of Caulis Clematidis Armandii

     Abstract: The studies about Caulis Clematidis Armandii's textual research, resources, chemical constituent, quality evaluation and pharmacological action are reviewed in this paper for its further research and application.

     Key words: Caulis Clematidis Armandii; Textual research;

    Resources; Chemical constituent; Quality evaluation; Pharmacological action

     Chuan Mu Tong for the more commonly used traditional Chinese medicine, its tasteless, slightly bitter, cold, hearts, lungs, small intestine, bladder through, with diuretic

    Tonglin, pass through the milk under the effect, Gu Chang for the edema, gonorrhea, urine unreasonable, joint numb pain, less milk embolism after closed treatment. "Chinese Pharmacopoeia" 2005 edition of ? provides for their plant

    sources Ranunculaceae Clematis Clematis armandii Clematis armandii Franch. Or hydrangea vine Clematis montana Buch .-

    Ham.'s Dry cane. In addition to these two kinds of plants, according to literature, there are more than ten kinds of plants belong to the same as Chuanmutong medicine, such as

    coarse teeth Clematis C. argentilucida WT Wang, a blunt calyx clematis such as C. peterae Hand-Mazz.

     In recent years, Guan Mu Tong for containing aristolochic acid, kidney toxicity has been banned at home and abroad, and

    Guan Chuan Mu Tong Mu due to the traditional wooden gang-pass

    class medicine, in this storm also affected. Therefore, the understanding of the status quo Chuanmutong research resource for the rational development and utilization of important practical significance. In this, special right Chuanmutong In recent years, herbal medicine research, resources, status, chemical composition, quality and pharmacological aspects of the role of research are summarized below.

     1 Textual research

     Chuan Mu Tong Herbs was first seen in the Song Dynasty, "Certificate Class Materia Medica" grass pass under the "state of Tong Xie grass" [1], similar to the current textual Ranunculus Ke Chuan Mu Tong. "Compendium of Materia Medica" Pass Grass item to download: "This year's wood-pass, there are

    purple, white 2-color, purple Weixin those thick-skinned, thin

    unleavened white person. Sutra Introduction Weixin, do not record made sweet, are both Tom Lee have encountered also "[2]. From the description of view, similar to present-day

    white Chuanmutong. "Plants were actually map test" collection contains four Akebia (Akebia mountains, wooden-pass, large

    wooden pass, Dian Huai Akebia), and a hydrangea vine are all run Ranunculaceae Clematis, and now used by Kawaki pass is

    similar to [3]. The Qing Dynasty in Sichuan and local Materia Medica, "Tian Bao Materia Medica" records (4 plum) "4 plum to the wood-pass, 4 Mahogany side to expensive. Informality cold-

    temperature gas disease pain, can benefit a hundredfold reactive urine" [4]. According to Xie Wan and other "A New Tian Bao Materia Medica" in the textual research that "four-

    mei," namely, wooden pass RANUNCULACEAE Clematis. Armandii Franch. Or hydrangea vine C. montana Buch .- Ham.'s Dry cane.

    Indicating that they have been in Sichuan Province will

    Chuanmutong medicinal use habits. Chuanmutong one from in the modern "Chinese medicine specimen Figure shadow," Copies of a Pieces (cross section) next to the mark "Chuan Mu Tong" [5]. "Sichuan Chinese Medicine Chi" [6] "Akebia" under the alias

    known as "Chuan Mu Tong." "Chinese Pharmacopoeia" ? edition

    of the Ministry in 1963 began accepting set Chuanmutong, and

    follows the name, but only a wooden pass a kind of plant origin. 1977 edition to 2005 edition of income contained in the plant are small wooden pass and Hydrangea vines [7].

     2 Resource Status

     Chuan Mu Tong of commercial drugs are derived from wild resources, the resources are mainly distributed in Sichuan, Chongqing, Yunnan and Guizhou provinces, Sichuan, in its main

    producing 800 ~ 3 200 m altitude of the mountains are distributed. Among them, wooden-pass are mainly distributed in

    Sichuan Basin, the edge of the mountains and valleys Southwest Sichuan mountain areas, elevation 600 ~ 1 600 m, such as Emei, Dujiangyan, Xichang, and Leibo, the United States regardless, Florida, Ping Shan, Gu Lin, Tian-quan, Yaan, etc. ; Hydrangea

    vine distribution is relatively high altitude, mainly at an altitude of 1 200 ~ 3 900 m high mountain valleys of western Sichuan areas, such as Jiuzhaigou, Songpan, Wenchuan, Li

    County, Kangding, Tianshan, Leibo, Luding, Emei, etc. [ 8,9]. Commodity survey shows that the market circulation Chuanmutong Ranunculaceae Clematis actually comes from a variety of plant stems, such as Sichuan, Chongqing production Chuanmutong

    mainstream varieties of plants and crude wooden tooth Clematis pass, followed by the Clematis is a blunt calyx, while the Pharmacopoeia contains varieties of hydrangea vine in commodities is very difficult to get the view, its causes and

    its growth higher elevations, transportation inconvenience to the [10].

     3 Chemical Composition

     Chuan Mu Tong containing mainly triterpenoid saponins, flavonoids and lignans.

     Wooden Messenger 3.1 saponin saponin saponin, after

    hydrolysis, there are two, one of which oleanolic acid [11]. Hydrangea vine leaves with with oleanolic acid as aglycone of the hydrangea vine saponins A, B, C (Clementanoside A, B, C) [12,13] and in hederagenin of daidzein and three of the six sugar sugar saponin , such as: (3 O β pyran-ribose)

     (1 3) α rhamnopyranosyl (1 2) α

    arabinopyranosyl - hederagenin 28 O α L

    rhamnopyranosyl (1 4) β D glucopyranosyl (1 6)

     β glucopyranoside [Hederagenin (3 O β

ribopyranosyl) (1 3) α rhamnopyranosyl (1 2)

     α arabinopyranoside 28 O α L

    rhamnopyranosyl (1 4) β D glucopyranosyl (1 6)

     β D glucopyranoside], Chang Harufuji sapogenin - (3

     O β pyran-ribose) (1 3) α rhamnopyranosyl

     (1 2) α pyrano arabinoside [Hederagenin (3

    O β ribopyranosyl) (1 3) α rhamnopyranosyl-(1

     2) α arabinopyranoside] [14], stem contains hederagenin 3 O α L arabinopyranoside, hederagenin 3 O α L rhamnopyranosyl (1

    2) α L arabinopyranoside, hederagenin-3 O α

     L arabinopyranosyl (1 2) α L

    arabinopyranoside [15], 3 O β D glucopyranosyl

    28 O β D galactopyranosyl (1 6) [α L

    rhamnopyranosyl (1 2)] β D glucopyranosyl 3β

     hydroxy olean 12 en 28 oate [16], etc. Saponins.

     3.2 flavone flavonoid glycosides containing wooden Pass:

    5,4 ' 2-hydroxy 3' methoxy-flavone 7 O (1

    ", 6" O β L pyran-buckthorn) β

    glucopyranoside (clematine) [17].

     3.3 Lignans wooden pass contains armandiside, liriodendrin, () pinoresinol 4,4 ' O bis β D

    glu copyranoside, () pinoresinol 4' O β D

    glucopyranoside, () syringa -resinol 4 ' β D

    glucopyranoside, () lariciresinol 4,4' O bis β

    D glucopyranoside, () lariciresinol 4 O β D

    glu-copyranoside, () lariciresinol 4 ' O β D

    glu copyranoside, salvadoraside such as lignans [18].

     3.4 Other wooden-pass also with 2,7 - dimethoxy--5 -

    methyl-chromone, 24R-ethyl-5α-cholest-3β, 6α-diol,

    daucosterol, esculetin dimethyl ether, Hook catechin

    (Berchemolide) and other ingredients [19]. Hydrangea vine still containing α-amyrin (α-Amyrin), β-amyrin (β-Amyrin), friedelin (Friedelin), 25 alkane (n-Pentacosane), 28 alcohol (N - Octacosanol), β-sitosterol and β-sitosterol glucoside and other constituents [20].

     4 Quality evaluation

     Chuanmutong from different sources (wooden pass,

    hydrangea vine, crude and blunt calyx tooth Clematis Clematis), may be based on its stem traits (such as thickness, surface longitudinal edges, longitudinal grooves and cross-

    section of gray-black gum characteristics of objects) and the organization structure (such as the thick-walled cells, phloem

    and xylem ring features) to identify [21]. For the Mu-Tong,

    Chuan Guan Mu Tong Akebia and three kinds of medicinal herbs Akebia class identification, in addition to the traditional

    character and microscopy addition, LC-MS method showed that

    Lardizabalaceae Ranunculus Ke Chuan Mu Tong Akebia and contain more similar to composition, similarity is greater, and Guan Mu Tong and the first two very different, similar ingredients

    less [22]; ultraviolet spectrum group method showed that three of water, anhydrous ethanol, chloroform and petroleum ether UV spectra of four infusion groups map shifts and peak shape is very close, but there are significant differences in

    absorption coefficient can be used as identification based on [23]. Chuan Mu Tong can be generated by the hydrolysis of oleanolic acid, "Chinese Pharmacopoeia" without the determination of items, Tang Sheng-wu, etc. [24] was

    determined by TLC-scanning Chuanmutong of the four kinds of

    plant stems decoction of oleanolic acid content, results showed that the blunt calyx clematis oleanolic acid were significantly higher than the wooden pass, Hydrangea Clematis vines and coarse teeth, and for the first time from the coarse

    teeth, and blunt calyx Clematis Clematis hydrolyzate The detection of oleanolic acid. Qing Lin Sen et al [25] established the use of HPLC determination after hydrolysis Chuanmutong medicinal content of oleanolic acid method and with the LC / MS method was determined by Chuanmutong in aristolochic acid content, the results indicate that Chuan Mu Tong ? samples of aristolochic acid content of the USFDA under the provisions of the limits (0.5 μg * g-1), that the

    clinical use of safety Chuanmutong. Reposted elsewhere in the

    paper for free download http://

     5 Pharmacological Research

     5.1 diuresis Chuanmutong obvious diuretic effect, the water decoction of 20 g / kg to rats gavage, 24 h average voiding percentage (167.32 ? 4.91)%, showed a significant

    diuretic effect (P

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