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Burn hot burn treatment Filmogen I, Experimental Study of_123

By Tony Butler,2014-10-30 11:40
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Burn hot burn treatment Filmogen I, Experimental Study of_123

Burn hot burn treatment Filmogen I, Experimental Study of

     Authors: Zhao Zhonghua, Wang Yuying, Xiu-Zhen

    Han, Tong Li

     Abstract Objective To study the burn Filmogen I, on experimental therapeutic effects of hot burn. Methods The rats

    were randomly divided into experimental group (burn Filmogen I, group), positive control group (MEBO group) and negative control group (blank control group). ? degree superficial

    burns caused by rats and ? degree burn animal model group

    were administered coated, single-cage rearing, observing the

    first days of wound 5,10,15 scab scab off the area and healing time. Results of the experimental group the first 15 days of the small size of the wound scab, scar healing time is short, compared with the negative control group, significant difference (P <0.01), compared with the positive control group without statistical significance. Conclusion Filmogen I, treatment of burns burns burns curative effect.

     Key Words Burn Remover-I; scalding burns; Pharmacodynamic

     Abstract: ObjectiveTo study the effects of thecal dosage form of burn on scalded and burned rats.MethodsRats were randomly divided into test group (thecal dosage form of burn), positive control group (moist burm ointment) and negative

    control group (no treatment) respectively . The drugs were administered topically on the surface of scalded and burned places respectively after superficial partial thickness scald and burn in rats.The rats were bred separately. The scabbed areas of the wound on the fifteenth day and the decrustation time were recorded.ResultsThe scabbed areas of the wound on the fifteenth day were smaller and the decrustation time was shorter of the test group than that of the negative control

    group with significant differences (P <0.01), but at the same level with the positive control group.ConclusionThecal dosage form of burn appears to be an effective preparation for treating scald and burn.

     Key words: Thecal dosage form of burn; Scalds and burns; Pharmacodynamics

     Burn Filmogen I, Affiliated Hospital of Inner Mongolia University for Nationalities in the long-term clinical

    application, based on the selected treatment ? degree burns

    following hot paste Remover, apply on the wound this medicine can play a protective film role in promoting natural wound healing, has pain, reduce leakage, shorten the course, reduce scar formation and reduce the effectiveness of disability and

    so on. In order to further evaluate its efficacy, and we have carried out a major prescription pharmacodynamics experiments. Are reported below.

     1 Materials

     1.1 Animal Health Wistar rats weighing 150 ~ 200 g, male and female are available, from the Animal Room of Inner Mongolia University for Nationalities.

     1.2 Drugs and reagents burn Remover I, Inner Mongolia University for Nationalities Hospital preparation room self-

    control, batch number 990,812; MEBO MEBO pharmaceutical

    factory in Shantou Special Economic Zone, Lot No. 20,020,604.

     2 Methods and Results

     2.1 The impact of scalded rats [1,2] to take Wistar 30 rats were randomly divided into experimental group (burn Filmogen I, group), positive control group (MEBO group) and

    negative control group (blank the control group) 10. In rats painted with 10% sodium sulfide back hair removal agents, hair removal area after a few minutes gently scrape mouse hair, washed with water shed areas, so that the back hair removal

    area of about 30 cm2. Hair removal after 24 h, with 1% pentobarbital sodium by 30 mg / kg of narcotic. Back hair removal area placed a diameter of 5cm triangular flask, pour 70 ? water, its inside, during a meeting in order to change the water temperature is kept 70 ?, 15 s later, resulting in

    superficial ? degree burn. Scalded 30 min after the animals caged points, respectively, in the burn area smear administration in the experimental group will burn Filmogen-I

    (300 ? 50) mg Apply evenly burn site; positive control group

    will MEBO (300 ? 50) mg Apply evenly burn site; negative control group were not medication. Treatment group are sterile gauze dressing, dressing 1 / d. No. 5,10,15 rats observed three days of wound healing scab scab off the area and time of

    the experimental data t test. The results in Table 1. Table 1 Burn Remover ? on rat experimental burn effects (abbreviated) reposted elsewhere in the paper for free download http://

     Can be seen from Table 1, light experimental group ?

    degree burn wounds scab 15 days, an area of reduced healing scab off time (P <0.05, P <0.01), compared with the negative control group, significant difference; experimental group and the positive control group, the first days of wound 5,10,15 scab scab off the area and healing time there was no significant difference.

     2.2 The impact of burn rats [3] to take Wister rats 30, group, hair removal, and anesthesia with 2.1. A diameter of 3.2 cm with 95% alcohol-impregnated filter paper sheet (the

    middle to open a small hole) on the rat back shed area spot burning filter paper, and continue to the middle hole from the filter paper with the syringe by adding alcohol, continued to burn. 15 s later, removed pieces of paper, put out the fire, causing ? degree burn. Drug delivery methods and observe the targets were the same 2.1. The results in Table 2. Table 2 burn Filmogen ? on rat experimental burn effects

    (abbreviated)

     Can be seen from Table 2, ?-degree burns the

    experimental group the first 15 days of the wound scab area reduced the healing scab off time (P <0.05 or P <0.01), compared with the negative control group, significant difference; experimental group and 5,10,15 positive control group the first days of wound healing scab scab off the area and the time there was no significant difference.

     3 Discussion

     Burn Remover No. ? by the donkey-hide gelatin, Burnet,

    turtles and other version of the composition of the compound

    traditional Chinese medicine preparations, Fang convergence of all drugs have a role in hemostasis, which they contain components related to tannin and calcium, of which the Turtle version of heat sedation, Burnet has a detoxifying anti-

    inflammatory effect. Therefore, the Remover spread onto the

    surface of the skin burns hot, can form a layer of protective film to reduce leakage, effective protection, closed wounds, through heat, detoxification and anti-inflammatory role in

    accelerating wound healing and reduce scar size. The results

    show that burn Remover No. ? can significantly shorten the

    healing time of scab off. Confirmed the treatment of burns burns burns Remover No. ? curative effect.

     References

     [1] m-ching for example, GUO Shou-Yan, WANG Bao-Mei, et

    al. Rat superficial ? degree burn test model of the

    pathological studies [J]. Shanghai Second Medical University, 1998,18 (1): 54.

     [2] Shi new. Medical animal experimental methods [M]. Beijing: People's Health Press, 1980:245.

     [3] Li Ao. Burn Therapy, 2nd Edition [M]. Beijing: People's Health Press, 1995:650. Reposted elsewhere in the paper for free download http://

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