Bio-flavonoids on the cardiovascular, digestive and analgesic effect of research_45

By Roberto Allen,2014-10-30 11:22
8 views 0
Bio-flavonoids on the cardiovascular, digestive and analgesic effect of research_45

    Bio-flavonoids on the cardiovascular, digestive and analgesic effect of research

     Abstract Objective To review the recent bio-flavonoid

    compounds in the cardiovascular, digestive, etc. are reviewed. Methods to check the two more than thirty domestic and foreign literature, to conduct systematic retrospective analysis and synthesis. The results of extensive pharmacological effects of plant flavonoid, in which the cardiovascular, digestive system abnormalities inhibition is particularly evident in a high

    practical value. Conclusion flavonoid compounds are used as resources for new drug development worthy of attention.

     Key words bio-flavonoids; cardiovascular effect; digestive role of the

     In recent years, bio-flavonoids compounds has achieved

    many encouraging results, especially in the cardiovascular, digestive and analgesic role. In this paper, recent progress in related research and its clinical application are summarized below.

     A cardiovascular system

     1.1 Astragalus complanatus Astragalus complanatus flavonoids flavonoids (total flavonoid fractiono Astra) stems from the legume Astragalus bian to separate the dry mature seeds derived from the early 20th century, 80 years Yoon Jong-

    soo, etc. [1] observed that had an initial intravenous

    injection of sand Yuan sub-decoction and the total flavonoids

    can cause blood pressure decreased significantly, Jing-Xin Li

    et al [2] reported that total flavonoids of Astragalus

complanatus renal hypertensive rats (RHR) marked

    antihypertensive effect, its mechanism may be related to the decrease of angiotensin (Ang ) related to the level. WU Jie et al [3] that Astragalus complanatus flavonoids can inhibit the myocardial cells calcium influx.

     1.2 TFH (TFH) Seabuckthorn in many similar

    pharmacological effects with ginkgo and ginkgo (TFG) of anti-

    heart and brain ischemia has been widely applied in clinical practice, Wang Liqun, etc. [4] experimental results show that, TFH, and TFG right the work of isolated rat heart function

    after myocardial ischemia and hemodynamics in various indicators of the role of different degree of improvement is mainly reflected in the can significantly reduce the ischemia LVPSP, dp / dtmax decreased, TFH was superior to TFG.

     Flavonoid antioxidant, eliminating free radicals. Wu Ying et al [5] studies have shown that sea buckthorn flavonoids on myocardial ischemia-reperfusion injury can significantly

    reduce the ischemia-reperfusion injury in zone ultrastructural pathological changes in myocardial tissue of rats

    significantly increased SOD activity and reduce the MDA's generation. TFH on myocardial ischemia-reperfusion injury in

    rats may be related to increased free radical scavenging activity and inhibit lipid peroxidation reaction.

     1.3 epimedium flavonoids such as Ashland's [6] studied the flavonoids of Epimedium (TFE) on the role of adrenergic receptor blockers and found that TFE selectively block away from the body and the whole animal cardiac β1 receptors, on

    the trachea β2 receptor and vascular smooth muscle α

    receptor non-blocking role, in this study for clinical

    application of the treatment of angina pectoris Epimedium provides a theoretical basis.

     1.4 TFM Hong Cheng et al [7] reported that using TFM 10 mg / kg ip will be delayed aconitine-induced arrhythmia in

    rats appeared time and shorten the duration; raise the threshold calcium chloride-induced arrhythmia dose; increase

    wow Pakistan-induced guinea pig arrhythmia due to the

    consumption; also against myocardial ischemia-reperfusion-

    induced arrhythmias in rats, indicating that TFM has a wide range of anti-arrhythmic effect. TFM can significantly reduce the thyroxine-induced cardiac hypertrophy in rat heart weight,

    shortening of myocardial fiber diameter, reducing ventricular protein and RNA content, reduced ventricular Na-K ATP enzyme

    and Na-Ca2 ATP activity, indicating that TFM on thyroid hormone-induced inhibition of cardiac hypertrophy, suggesting a reversal of TFM-induced cardiac hypertrophy with heart

    failure have a certain sense [8].

     2 digestive system

     2.1 Huang TF Huang TF dose-dependently inhibit the

    absorption of bile salt (P <0.01), with colestyramine the role of inhibition of bile salt absorption in comparison, there is no significant difference ( P> 0.05). Tip inhibit the

    absorption of bile salts may be yellow SSTF lipids regulating effects of one of the mechanisms. Huang TF applied to lipid-

    lowering and prevention of coronary heart disease may be better than colestyramine. However, Huang TF inhibit absorption of bile salts, while the absorption of fat-soluble

    vitamins would not be inhibited further investigation [9].

     I am Room Recent studies have shown that C.speciosa according to dose of extract inhibited gastrointestinal motility; inhibit spontaneous contraction of ileum and non-

    competitive antagonist of acetylcholine-induced stomach fundus

    smooth muscle contraction dose-response curves; the same time

    can be reduced Ca2 induced contraction in rabbit ileum, papaya extract on gastrointestinal smooth muscle relaxation and anti-

    relating to the role of calcium [10]. Tips C.speciosa have a spasm.

     3 anti-inflammatory analgesic

     3.1 Ginkgo biloba flavonoids

     Writhing in the mouse model, subcutaneous injection of Ginkgo biloba flavonoids 20 ~ 80 mg / kg, can significantly

    reduce the number of writhing in mice, and a dose-dependent

    relationship; in the mouse hot plate model, subcutaneous, and intracerebroventricular injection of Ginkgo biloba flavonoids may significantly prolong the latency of paw-licking in mice

    showed that ginkgo biloba significantly analgesic effect of total flavonoids and its analgesic effect may be the involvement of central mechanisms [11].

     3.2 Rutin Bi-Wei Song et al [12] The analgesic effect of rutin results show that rutin (6.25 ~ 100 mg / kg, ip) in a dose-dependent inhibition of writhing response in mice; rutin (50 ~ 100 mg / kg, ip) markedly improved in mice screamed stimulation threshold significantly prolong the mice hot-plate

    paw-licking response latency, indicating that rutin has

    analgesic effect. Stronger analgesic effects than aspirin, but weaker than morphine.

     Wild Papaya 3.3 Papaya Department Lardizabalaceae wild papaya species, with Qufeng pain relief. Wild papaya on the myelin sheath and axon membrane has affinity myelin sheath and axon membrane can cause changes in the structure, leading to nerve conduction block [13]. I am Room The experimental results show that: capital papaya extract on acetic acid, the temperature-induced pain, a better analgesic effect, but p-

    xylene-induced ear swelling of the swelling effect will be negligible [14].

     3.4 buckwheat leaves flavonoids Buckwheat leaves flavonoids (TFBL) can significantly reduce the formation of granuloma, reducing capillary permeability and inhibiting ear

    swelling, indicating TFBL has obvious analgesic anti-

    inflammatory effects [15]. The mechanism may be related to TFBL the main ingredient contained in the rutin and quercetin. It was reported that quercetin on the activity of 12-

    lipoxygenase has a strong inhibitory effect, may affect the metabolism of arachidonic acid. Rutin, quercetin analgesic mechanisms related with the calcium antagonist. TFBL have a clear free radicals, anti-lipid peroxidation [16], may also be involved in anti-inflammatory effect, needs further

    investigation. Buckwheat leaves rich in natural resources, their extraction TFBL virtually non-toxic, worthy of further

    development and utilization. Reposted elsewhere in the paper for free download http://

     3.5 total flavone Abelmoschus manihot (TFA) of total flavonoids Abelmoschus manihot TFA (ig or ip) in mice can be inhibited to varying degrees, writhing; TFA (140,280 mg / kg, ig) can formalin-induced pain in mice the ?, ? reaction

    significantly reduced, TFA (ip) on formalin-induced pain in

    the ipsilateral ip can produce the same inhibitory effect, but the opposite ip formalin-induced pain in mice had no

    significant impact; arterial injection of TFA 200 mg / kg can

significantly reduce the KCl-induced pain response in rabbits;

    continuous medication can jump in the mouse experiments, TFA-

    positive rate is 0. The above results show that the TFA has some analgesic effect and the local administration of an effective, continuous non-addictive drug. TFA's analgesic

    mechanism may be different from that of opiates, but also different from the non-steroidal anti-inflammatory drugs, is

    an analgesic mechanism worthy of further exploration of new analgesic drugs [17].

     3.6 propolis flavonoids (TFP) propolis flavonoids have a

    wide range of biological activity, such as analgesic role. After the injection of TFP can reduce the number of mice writhing. Hot-plate test results also show that TFP extend the paw-licking latency in mice, namely, delayed pain reaction. Formaldehyde-induced pain model results show that in the first hours after the injection of TFP is relatively pain reaction in mice had no significant effect, but can significantly reduce the second phase of the pain reaction. Description TFP on inflammatory pain response induced significant analgesic

    effect. icv TFP low-dose (for the ip dose of 1 / 20, that is, 5 mg / kg), they can extend the warm bath tail response latency induced contraction, suggesting that TFP in mice with a central analgesic effect. NO is known peripheral and central

    pain in order to participate in the regulation of different levels. High dose of TFP in inhibiting mouse hot-plate

    reaction time can reduce the levels of NO in brain tissue in mice, suggesting that TFP may be related to analgesic effect in mice brain tissue release of NO-related; In addition, ip

    TFP in inhibiting mouse hot-plate reaction At the same time,

    can reduce brain tissue, serum MAD concentration, suggesting that the analgesic effect of TFP and inhibit free radicals and peroxides there is a certain relationship. PEGz is a very important medium of pain, PEG-induced pain of peripheral role

    has long been clear. ip TFP can reduce the brain tissue and serum in PEGz content, suggesting that the analgesic effect of TFP and inhibit synthesis of PEG there is a certain

    relationship. TFP in a variety of pain in animal models have shown significant analgesic effect and may be by reducing the brain tissue NO, MAD, PEG content and the blood in the MAD, PEG content to play analgesic effect. As to the exact

    mechanism of analgesia remains to be further research [18].

     4 Other

     Hyperin, rutin, quercetin and so have a good analgesic effect [19], its mechanism and Ca2 antagonist, in particular, Hyp, not only in a variety of systemic analgesic models play a

    role, but also in the rabbit saphenous nerve discharge, rabbit ear skin infiltration of local K-induced pain model of the

    local analgesic effect of a more favorable [20], its mechanism of action of morphine and aspirin are different, the Department of a new analgesic.

     In conclusion, bio-flavonoids wide variety of sources, with analgesic anti-inflammatory and other pharmacological effects, and some even are widely used in clinical practice, is a large class worthy of further research and development of



     [1] Yin ZZ, Chen SH, Ma BB.Pharmacological studies of totalFlavonoid fraction of Astragalus complanatus [J]. R. Brown. Pharmacol Clin Chin Mater Med, 1988,4 (4): 26.

     [2] Jing-Xin Li, Xue Bing, Chen Lian-Bi, et al.

    Astragalus complanatus total flavonoids of the

    antihypertensive effect in hypertensive rats and angiotensin content of [J]. Chinese Journal of Pharmacology and Toxicology, 2002, 16 (5): 336.

     [3] Wu Jie, Xiao-Jiang Yu, Mahin, et al. Astragalus

    complanatus total flavonoids in guinea pig ventricular papillary muscles and cultured rat myocardial cells electrophysiological effects [J]. Chinese Pharmacology Bulletin, 1994,15 (4): 343.

     [4] Li-Qun Wang, Zheng Jinsheng. TFH (TFH) and ginkgo flavonoids (TFG) Comparative study of cardiovascular

    pharmacodynamics [J]. China Coal Industry Medicine, 2002,5 (12): 1205.

     [5] Wu Ying, Wang Bingwen, Wang Yi, et al. Seabuckthorn flavonoids on rat myocardial reperfusion injury in rats [J]. Chinese Pharmacology Bulletin, 1997,13 (1): 53.

     [6] Ashland's, Chen Weining. Epimedium total flavonoids of β1-adrenergic receptor-specific blocking effect [J].

    Chinese Pharmacology Bulletin, 1994,10 (4): 311.

     [7] Cheng Hong, Liu Wei-Wan, Chen Xiang, et al. TFM on

    experimental arrhythmias [J]. Hubei Medical University,

    1999,20 (1): 28.

     [8] Cheng Hong, Liu Wei-Wan, Tu Zhi-Dong, et al. TFM on

    thyroxine-induced cardiac hypertrophy in inhibition of [J]. Chinese Pharmacology Bulletin, 2000,16 (3): 277.

     [9] Zhou Chong Tan, Feng, Zhao-hui, et al. Huang TF on

    isolated rat ileum bile salt absorption [J]. Shanxi Medical Journal, 2003,32 (12): 1093.

     [10] Yang Xinghai, Liu Wei, Qian Jing-ping, et al. Owned

    ethanol extract of papaya on gastrointestinal smooth muscle of the experimental study [J]. Sichuan Traditional Chinese Medicine, 2004,22 (3): 116.

     [11] Chen Zhiwu, Fang Ming, Ma CG, et al. Ginkgo biloba flavonoids analgesic effect [J]. Anhui Medical University,

1997,32 (1): 15.

     [12] Bi-Wei Song, et al. Rutin analgesic effect [J].

    Anhui Medical University, 1995; 30 (3): 177.

     [13] Ye Wenbo, Zhang Hui Qi, Yung-Hua, et al. Stauntonia

    saponins on rat nerve myelin sheath and axon of the role of the membrane [J]. Neural anatomy, 2003,19 (3): 311.

     [14] Liu Wei, Yang Xinghai, Qian Jing-ping, et al. Owned

    ethanol extract of papaya analgesic anti-inflammatory effects

    of experimental study [J]. Sichuan Traditional Chinese Medicine, 2004,22 (8): 6.

     [15] Wang Yuan-fu. Sweet buckwheat leaves flavonoids

    analgesic anti-inflammatory effects of experimental study [J]. Shanghai Journal of Traditional Chinese Medicine, 2004,38 (11): 55.

     [16] Han Shuying, Zhu Lisha, Shu-Mei Liu, et al.

    Buckwheat leaves flavonoids and lipids and anti-lipid

    peroxidation [J]. China Coal Industry Medicine, 2002,5 (7): 711.

     [17] Fan, Dong 61, Zhiwu, et al. Abelmoschus manihot analgesic effect of total flavonoids [J]. Traditional Chinese Medicine and Clinical Pharmacology, 2003; 19 (1): 12.

     [18] Zhang Bo, Wang Dongfeng, Wang Shuang, et al. Propolis flavonoids analgesic effect and its mechanism [J].

Chinese Pharmacy, 2005,16 (19): 1458.

     [19] Bi-Wei Song, Tian Wei, Liu Ying Xue, et al.

    Quercetin analgesic effect of [J]. Anhui Medical University, 1994,29:168.

     [20] Chen Zhi Wu, Hong-Guang Wang, Fang, et al. A simple

    and practical model for peripheral analgesia [J]. Chinese Journal of Pharmacology, 1990,6:394. Reposted elsewhere in the paper for free download http://www.hi138 . com

Report this document

For any questions or suggestions please email