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Anti-inflammatory analgesic ancient Uncaria Experimental Study of pharmacological effects_476

By Tony Graham,2014-10-30 10:17
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Anti-inflammatory analgesic ancient Uncaria Experimental Study of pharmacological effects_476

    Anti-inflammatory analgesic ancient Uncaria Experimental Study of pharmacological effects

     Author: Zhang Xingshen Zhoufang Liao Yue-kui Li

    Li Xiong Jing-Yun Lan Guo-Liang Chen Wutangweijiang Hui Qin

    Liping Liang Fei

     Abstract Objective To study the ancient Uncaria Decoction analgesic anti-inflammatory pharmacological effects. Methods The mouse hot plate and writhing analgesia test, observe the ancient Uncaria Decoction analgesic effect was observed in mice capillary permeability and xylene effects on mouse ear swelling was observed its anti-inflammatory effect. Results of

    ancient Uncaria decoction can significantly increase pain threshold in mice, reducing capillary permeability, inhibit the inflammatory response induced by xylene, can significantly reduce the ear swelling in mice. Conclusion of ancient Uncaria decoction has obvious analgesic and anti-inflammatory effects.

     Key words ancient Uncaria; analgesic anti-inflammatory;

    pharmacological effects

     Abstract: ObjectiveTo study the anti

     inflammatory and analgesia actions of the Chinese medicine Gu Gou Teng solution. Methods The effect of Gu Gou Teng solution on analgesia was observed with the response of writhes and hot-plate tests. The effect of anti-inflammation

    was observed by mice inflammation models caused by dimethy benzene and mice models with reinforce permeability of abdominal cavity capillary caused by acetic acid. ResultsGu Gou Teng solution had a prominent analgesia effect. It could restrain the capillary permeability resulted from imflammation by dimethybenzene.ConclusionGu Gou Teng solution has significant effects of analgesia and anti-inflammatory on

    experimental mice.

     Key words: Gu Gou Teng; Anti

     inflammation and analgesic test; Pharmacology

     Ancient Uncaria also known as sea master, white leaf rattan, rattan horn, big dark consumption, etc., for the ancient plant Uncaria Asclepiadaceae Cryptolepis buchananiiRoem. Et Schult part of the ground. Multi-born

    sunny, climbing on other trees, located in Guangdong, Guangxi, Yunnan, Guizhou and other places. With Shujin vibrant, swelling and pain relief, detoxification and other effects, for the treatment of low back pain, abdominal pain, bruises,

    fractures, carbuncle sores, ringworm and other diseases [1]. At present, anti-inflammatory analgesic drugs, mostly western, and more side-effects, while the ancient Chinese herbal medicine Uncaria civil use was also the role in this respect should be worthy of research and development of analgesic anti-inflammatory drugs, yet its domestic and foreign pharmacological studies in this regard a detailed report. The scientific and technological research group of ancient Uncaria analgesic anti-inflammatory role of experimental research

    aimed at their further development and clinical application provide some theoretical basis.

     1 Materials

     1.1 Animals in mice of either sex, weight (20 ? 2) g, by

    the Experimental Animal Center of Guangxi Medical College to

    provide, animal证号1104, according to the experimental nature of the cage to feed and sex, free feed water.

     1.2 Instrument desktop centrifuge; XZB

     2B-type temperature-controlled hot plate instrument,

    Shandong Academy of Medical Sciences Manufacturing equipment

    maintenance stations, equipment number is: 3

     109

     1

     7

     6; 722 model grating spectrophotometer, Shanghai No. three analytical instrument factory, equipment number is: 3

     109

     4

     4

     93

     1.3 Drugs and reagents dry ancient Uncaria collected from Guangxi Baise area Tianlin County suburbs; sulfate Rotundine injection, Guangdong Province, Boluo Vanguard Pharmaceutical Group Co., Ltd. production, batch number 020,902; acetate, dexamethasone, Zhejiang Xian Ju Pharmaceutical Co., Ltd.

    production, batch number 040,405.