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Supplementary Table 1 Genes showing differential expression

By Gordon Smith,2014-11-25 19:13
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Supplementary Table 1 Genes showing differential expression

Supplementary Table 2: Gene Set Enrichment Analysis (GSEA). 177 gene sets were identified as sharing up-regulated genes with

    our data and 54 gene sets were identified as sharing down-regulated genes (NOM p-value ? 0.05 and FDR q-value ? 0.25).

    FWER Rank at Gene Set (Up-Regulated) Size ES NES NOM p-val FDR q-val p-val Max Leading Edge CARIES_PULP_UP 195 0.542 2.375 0 0.001 0.001 3690 tags=52%, list=21%, signal=66% CARIES_PULP_HIGH_UP 87 0.56 2.208 0 0.003 0.006 3878 tags=57%, list=22%, signal=73% TAKEDA_NUP8_HOXA9_3D_UP 177 0.493 2.137 0 0.005 0.016 2571 tags=36%, list=15%, signal=41% ERYTHPATHWAY 15 0.8 2.126 0 0.005 0.019 1517 tags=67%, list=9%, signal=73% LINDSTEDT_DEND_8H_VS_48H_UP 61 0.562 2.071 0 0.01 0.046 3773 tags=56%, list=22%, signal=71% CMV_HCMV_TIMECOURSE_12HRS_UP 25 0.65 2.051 0 0.012 0.07 3281 tags=60%, list=19%, signal=74% TSA_CD4_DN 17 0.719 2 0 0.023 0.145 2186 tags=53%, list=12%, signal=60% TAKEDA_NUP8_HOXA9_10D_UP 156 0.459 1.985 0 0.026 0.183 2005 tags=27%, list=11%, signal=30% SANA_TNFA_ENDOTHELIAL_UP 77 0.508 1.94 0 0.032 0.306 3315 tags=40%, list=19%, signal=49% CROONQUIST_IL6_RAS_UP 23 0.645 1.941 0 0.035 0.304 4406 tags=70%, list=25%, signal=93% UVB_NHEK1_UP 162 0.459 1.958 0 0.036 0.256 3509 tags=35%, list=20%, signal=43% IRITANI_ADPROX_DN 56 0.534 1.945 0.002 0.037 0.294 3314 tags=48%, list=19%, signal=59% IGF_VS_PDGF_DN 41 0.565 1.922 0 0.041 0.402 1366 tags=27%, list=8%, signal=29% UVB_NHEK1_C2 22 0.656 1.917 0 0.041 0.428 3509 tags=59%, list=20%, signal=74% DAC_PANC50_UP 40 0.575 1.912 0.002 0.041 0.455 2324 tags=35%, list=13%, signal=40% HINATA_NFKB_UP 105 0.466 1.882 0 0.048 0.597 3024 tags=35%, list=17%, signal=42% DAC_BLADDER_UP 26 0.613 1.891 0.002 0.049 0.564 1147 tags=35%, list=7%, signal=37% HBX_HCC_UP 16 0.678 1.894 0.002 0.049 0.545 1769 tags=44%, list=10%, signal=49% TAKEDA_NUP8_HOXA9_16D_UP 143 0.442 1.867 0 0.051 0.668 2770 tags=31%, list=16%, signal=37% HSA04950_MATURITY_ONSET_DIABETES_OF_THE

    _YOUNG 20 0.633 1.883 0 0.051 0.596 3814 tags=60%, list=22%, signal=77% TAKEDA_NUP8_HOXA9_8D_UP 135 0.445 1.868 0 0.052 0.665 2448 tags=31%, list=14%, signal=36% STEMPATHWAY 15 0.691 1.869 0 0.054 0.661 966 tags=53%, list=6%, signal=56% BRG1_SW13_UP 42 0.548 1.854 0 0.056 0.724 4893 tags=55%, list=28%, signal=76% HSA04740_OLFACTORY_TRANSDUCTION 30 0.572 1.83 0.002 0.07 0.823 973 tags=23%, list=6%, signal=25% GALINDO_ACT_UP 76 0.478 1.833 0 0.071 0.813 3521 tags=33%, list=20%, signal=41% TAKEDA_NUP8_HOXA9_6H_UP 76 0.48 1.82 0 0.076 0.867 2732 tags=36%, list=16%, signal=42% VERHAAK_AML_NPM1_MUT_VS_WT_UP 158 0.429 1.808 0 0.078 0.899 3328 tags=36%, list=19%, signal=44% HSA04640_HEMATOPOIETIC_CELL_LINEAGE 83 0.465 1.813 0 0.079 0.883 2277 tags=37%, list=13%, signal=43%

    TAKEDA_NUP8_HOXA9_10D_DN 139 0.43 1.801 0 0.08 0.922 1938 tags=30%, list=11%, signal=34% RUTELLA_HEPATGFSNDCS_UP 142 0.432 1.802 0 0.081 0.92 3495 tags=36%, list=20%, signal=45% YANG_OSTECLASTS_SIG 39 0.526 1.808 0 0.081 0.898 1529 tags=38%, list=9%, signal=42% AGEING_KIDNEY_UP 362 0.381 1.795 0 0.082 0.932 3045 tags=29%, list=17%, signal=34% DER_IFNA_UP 62 0.481 1.79 0 0.082 0.945 3449 tags=35%, list=20%, signal=44% ADIPOGENESIS_HMSC_CLASS1_UP 16 0.649 1.792 0.004 0.082 0.937 3297 tags=50%, list=19%, signal=62% AGEING_KIDNEY_SPECIFIC_UP 165 0.407 1.764 0 0.085 0.975 3039 tags=32%, list=17%, signal=38% IL1_CORNEA_UP 61 0.49 1.785 0 0.085 0.955 3226 tags=38%, list=18%, signal=46% ICHIBA_GVHD 230 0.395 1.782 0 0.086 0.959 3253 tags=30%, list=19%, signal=37% IMMUNE_RESPONSE 211 0.396 1.765 0 0.087 0.972 2854 tags=31%, list=16%, signal=37% CMV_8HRS_UP 29 0.567 1.766 0.002 0.088 0.972 860 tags=21%, list=5%, signal=22% DEFENSE_RESPONSE 242 0.385 1.751 0 0.09 0.982 2489 tags=28%, list=14%, signal=32% HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTE

    RACTION 235 0.398 1.769 0 0.09 0.97 2260 tags=29%, list=13%, signal=32% IRITANI_ADPROX_VASC 146 0.418 1.766 0 0.09 0.972 3449 tags=36%, list=20%, signal=45% NAKAJIMA_MCS_UP 86 0.445 1.753 0 0.09 0.98 2263 tags=34%, list=13%, signal=39% ADIP_DIFF_CLUSTER2 39 0.53 1.755 0.004 0.09 0.979 2052 tags=26%, list=12%, signal=29% VIRAL_GENOME_REPLICATION 19 0.614 1.774 0.008 0.09 0.967 3694 tags=53%, list=21%, signal=67% HALMOS_CEBP_UP 47 0.505 1.756 0.002 0.091 0.979 2742 tags=34%, list=16%, signal=40% JNK_UP 28 0.557 1.771 0.007 0.091 0.968 810 tags=21%, list=5%, signal=22% IFN_ALPHA_UP 38 0.524 1.746 0.004 0.092 0.986 3449 tags=39%, list=20%, signal=49% SCHURINGA_STAT5A_DN 17 0.632 1.746 0.01 0.094 0.986 2365 tags=47%, list=14%, signal=54% NF90_UP 23 0.589 1.739 0.002 0.096 0.99 1147 tags=30%, list=7%, signal=33% IFNA_HCMV_6HRS_UP 48 0.498 1.737 0.002 0.097 0.991 3217 tags=33%, list=18%, signal=41% YAO_P4_KO_VS_WT_UP 66 0.462 1.727 0 0.101 0.993 1669 tags=23%, list=10%, signal=25% VIRAL_INFECTIOUS_CYCLE 28 0.552 1.731 0.004 0.101 0.993 3194 tags=43%, list=18%, signal=52% CHEMOKINE_RECEPTOR_BINDING 42 0.501 1.728 0.002 0.102 0.993 1600 tags=31%, list=9%, signal=34% BOQUEST_CD31PLUS_VS_CD31MINUS_DN 245 0.379 1.722 0 0.105 0.995 2400 tags=27%, list=14%, signal=30% INFLAMMATORY_RESPONSE 120 0.418 1.712 0.002 0.11 1 2489 tags=33%, list=14%, signal=38% CMV_HCMV_TIMECOURSE_20HRS_DN 37 0.507 1.713 0.005 0.11 1 2260 tags=35%, list=13%, signal=40% CELLULAR_DEFENSE_RESPONSE 50 0.483 1.715 0.002 0.112 1 2140 tags=36%, list=12%, signal=41% ADIPOGENESIS_HMSC_CLASS8_DN 30 0.533 1.713 0.009 0.112 1 1830 tags=30%, list=10%, signal=33% WIELAND_HEPATITIS_B_INDUCED 91 0.431 1.705 0 0.113 1 3349 tags=36%, list=19%, signal=45% TARTE_MATURE_PC 351 0.359 1.697 0 0.119 1 3066 tags=28%, list=18%, signal=33% SANA_IFNG_ENDOTHELIAL_UP 73 0.442 1.697 0.004 0.12 1 3253 tags=37%, list=19%, signal=45%

    ERM_KO_SERTOLI_DN 16 0.619 1.693 0.013 0.12 1 1352 tags=38%, list=8%, signal=41% GLUTATHIONE_TRANSFERASE_ACTIVITY 15 0.626 1.688 0.009 0.121 1 3087 tags=47%, list=18%, signal=57% CROONQUIST_RAS_STROMA_UP 24 0.562 1.693 0.012 0.121 1 1346 tags=29%, list=8%, signal=32% STAEGE_EFTS_UP 26 0.554 1.69 0.013 0.121 1 3101 tags=50%, list=18%, signal=61% METALLOENDOPEPTIDASE_ACTIVITY 26 0.54 1.683 0.015 0.122 1 1814 tags=31%, list=10%, signal=34% OXIDOREDUCTASE_ACTIVITY__ACTING_ON_CH_O

    H_GROUP_OF_DONORS 54 0.468 1.683 0.002 0.124 1 3739 tags=41%, list=21%, signal=52% KNUDSEN_PMNS_UP 73 0.438 1.683 0.002 0.125 1 2852 tags=30%, list=16%, signal=36% ZUCCHI_EPITHELIAL_DN 45 0.487 1.676 0.003 0.127 1 1148 tags=22%, list=7%, signal=24% VIRAL_REPRODUCTION 36 0.506 1.675 0.005 0.127 1 3194 tags=36%, list=18%, signal=44% HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE

    _DEGRADATION 22 0.567 1.677 0.004 0.128 1 1128 tags=27%, list=6%, signal=29% TSA_PANC50_UP 38 0.499 1.672 0.005 0.128 1 2424 tags=37%, list=14%, signal=43% VIRAL_REPRODUCTIVE_PROCESS 32 0.514 1.665 0.011 0.131 1 3194 tags=38%, list=18%, signal=46% GERY_CEBP_TARGETS 106 0.407 1.666 0.002 0.132 1 2686 tags=31%, list=15%, signal=37% ET743_HELA_UP 53 0.464 1.667 0.009 0.132 1 4173 tags=40%, list=24%, signal=52% AGED_MOUSE_MUSCLE_UP 29 0.523 1.662 0.016 0.132 1 3471 tags=48%, list=20%, signal=60% ELECTRON_TRANSPORT_CHAIN 98 0.412 1.641 0.007 0.134 1 5876 tags=62%, list=34%, signal=93% HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PA

    THWAY 92 0.414 1.639 0.002 0.135 1 1985 tags=23%, list=11%, signal=26% TAKEDA_NUP8_HOXA9_8D_DN 187 0.373 1.636 0 0.136 1 3165 tags=33%, list=18%, signal=40% AUXILIARY_TRANSPORT_PROTEIN_ACTIVITY 24 0.544 1.641 0.024 0.136 1 1300 tags=25%, list=7%, signal=27% INTERMEDIATE_FILAMENT 19 0.574 1.635 0.027 0.136 1 2032 tags=37%, list=12%, signal=42% BAF57_BT549_UP 214 0.371 1.646 0 0.137 1 3225 tags=30%, list=18%, signal=36% LEE_CIP_DN 63 0.433 1.633 0.005 0.137 1 2038 tags=29%, list=12%, signal=32% TAVOR_CEBP_UP 48 0.469 1.641 0.006 0.137 1 3280 tags=40%, list=19%, signal=49% LAL_KO_6MO_UP 62 0.443 1.648 0.007 0.137 1 1831 tags=29%, list=10%, signal=32% G_PROTEIN_COUPLED_RECEPTOR_BINDING 51 0.465 1.637 0.011 0.137 1 1784 tags=29%, list=10%, signal=33% INTERMEDIATE_FILAMENT_CYTOSKELETON 19 0.574 1.646 0.011 0.137 1 2032 tags=37%, list=12%, signal=42% PASSERINI_INFLAMMATION 24 0.542 1.643 0.012 0.137 1 2852 tags=46%, list=16%, signal=55% LVAD_HEARTFAILURE_DN 36 0.491 1.631 0.013 0.137 1 3107 tags=50%, list=18%, signal=61% CMV-UV_HCMV_6HRS_UP 114 0.393 1.644 0 0.138 1 2393 tags=23%, list=14%, signal=26% SHEPARD_NEG_REG_OF_CELL_PROLIFERATION 110 0.403 1.649 0 0.138 1 3319 tags=32%, list=19%, signal=39% CALCIUM_INDEPENDENT_CELL_CELL_ADHESION 19 0.565 1.656 0.009 0.138 1 1323 tags=26%, list=8%, signal=28% WANG_HOXA9_VS_MEIS1_DN 21 0.565 1.652 0.017 0.138 1 3439 tags=62%, list=20%, signal=77%

    LAL_KO_3MO_UP 47 0.475 1.652 0.009 0.139 1 1529 tags=30%, list=9%, signal=33% IFN_BETA_GLIOMA_DN 43 0.48 1.649 0.015 0.139 1 3243 tags=33%, list=19%, signal=40% LEE_TCELLS7_UP 15 0.631 1.654 0.016 0.139 1 3608 tags=67%, list=21%, signal=84% IFNA_UV-CMV_COMMON_HCMV_6HRS_UP 26 0.52 1.629 0.025 0.139 1 4241 tags=50%, list=24%, signal=66% CHIARETTI_T_ALL_DIFF 248 0.355 1.623 0 0.143 1 3500 tags=33%, list=20%, signal=40% RESPONSE_TO_WOUNDING 177 0.368 1.624 0 0.143 1 2489 tags=28%, list=14%, signal=32% BENNETT_SLE_UP 26 0.531 1.62 0.018 0.144 1 2428 tags=35%, list=14%, signal=40% TSADAC_PANC50_UP 40 0.475 1.616 0.007 0.145 1 2909 tags=35%, list=17%, signal=42% OXIDOREDUCTASE_ACTIVITY_GO_0016616 50 0.458 1.62 0.009 0.145 1 3739 tags=40%, list=21%, signal=51% CHEMOKINE_ACTIVITY 41 0.479 1.616 0.015 0.146 1 1600 tags=29%, list=9%, signal=32% HOGERKORP_ANTI_CD44_UP 24 0.526 1.616 0.006 0.147 1 2398 tags=29%, list=14%, signal=34% MULTI_ORGANISM_PROCESS 134 0.387 1.61 0.002 0.151 1 2143 tags=25%, list=12%, signal=28% FLECHNER_KIDNEY_TRANSPLANT_REJECTION_UP 76 0.424 1.609 0.002 0.151 1 2365 tags=26%, list=14%, signal=30% ADIP_VS_PREADIP_DN 38 0.47 1.609 0.015 0.151 1 2517 tags=26%, list=14%, signal=31% DAC_IFN_BLADDER_UP 17 0.578 1.603 0.021 0.156 1 3011 tags=47%, list=17%, signal=57% FEMALE_GAMETE_GENERATION 16 0.596 1.602 0.028 0.156 1 2000 tags=31%, list=11%, signal=35% ET743_SARCOMA_72HRS_UP 58 0.442 1.597 0.008 0.16 1 3403 tags=33%, list=19%, signal=41% CMV_UV-CMV_COMMON_HCMV_6HRS_UP 19 0.557 1.598 0.014 0.16 1 4276 tags=53%, list=24%, signal=70% APOPTOSIS_KEGG 48 0.457 1.595 0.009 0.161 1 1637 tags=19%, list=9%, signal=21% IFN_GAMMA_UP 37 0.472 1.594 0.011 0.161 1 3449 tags=32%, list=20%, signal=40% ECTODERM_DEVELOPMENT 72 0.415 1.587 0.007 0.162 1 3237 tags=29%, list=18%, signal=36% KERATINOCYTE_DIFFERENTIATION 15 0.59 1.591 0.029 0.162 1 5552 tags=67%, list=32%, signal=98% CELL_CELL_SIGNALING 380 0.332 1.59 0 0.163 1 3338 tags=33%, list=19%, signal=39% KANG_TERT_UP 79 0.409 1.588 0.004 0.163 1 3015 tags=30%, list=17%, signal=37% RESPONSE_TO_VIRUS 41 0.458 1.592 0.013 0.163 1 4206 tags=51%, list=24%, signal=67% TRANSFERASE_ACTIVITY__TRANSFERRING_ALKYL

    _OR_ARYL__OTHER_THAN_METHYL__GROUPS 26 0.515 1.589 0.022 0.163 1 3252 tags=31%, list=19%, signal=38% SHIPP_DLBCL_CURED_UP 29 0.493 1.579 0.016 0.171 1 3608 tags=45%, list=21%, signal=56% RADAEVA_IFNA_UP 48 0.443 1.58 0.017 0.171 1 2428 tags=27%, list=14%, signal=31% REPRODUCTION 226 0.346 1.568 0 0.178 1 3984 tags=37%, list=23%, signal=47% JECHLINGER_EMT_UP 57 0.429 1.568 0.008 0.179 1 2453 tags=32%, list=14%, signal=37% HSA00190_OXIDATIVE_PHOSPHORYLATION 107 0.384 1.57 0.012 0.179 1 3148 tags=34%, list=18%, signal=41% CROONQUIST_IL6_STROMA_UP 37 0.468 1.566 0.021 0.179 1 2561 tags=32%, list=15%, signal=38% INFLAMPATHWAY 27 0.507 1.573 0.022 0.179 1 2633 tags=44%, list=15%, signal=52% POSITIVE_REGULATION_OF_CELL_DIFFERENTIATI21 0.535 1.571 0.039 0.179 1 4146 tags=52%, list=24%, signal=69%

ON

    EXTRACELLULAR_MATRIX_PART 52 0.438 1.568 0.012 0.18 1 1010 tags=19%, list=6%, signal=20% BLEO_HUMAN_LYMPH_HIGH_24HRS_UP 92 0.394 1.563 0.003 0.182 1 3139 tags=33%, list=18%, signal=40% MATRIX_METALLOPROTEINASES 29 0.495 1.56 0.021 0.186 1 2436 tags=41%, list=14%, signal=48% PROLIFERATION_GENES 368 0.332 1.556 0 0.189 1 3241 tags=28%, list=19%, signal=33% LEE_E2F1_UP 62 0.426 1.557 0.014 0.189 1 2957 tags=31%, list=17%, signal=37% HBX_NL_DN 16 0.564 1.552 0.036 0.193 1 2488 tags=44%, list=14%, signal=51% TIGHT_JUNCTION 26 0.504 1.545 0.032 0.203 1 3675 tags=35%, list=21%, signal=44% VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX 15 0.575 1.543 0.039 0.203 1 3095 tags=53%, list=18%, signal=65% CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRAN

    SDUCTION 134 0.365 1.541 0.003 0.204 1 2852 tags=28%, list=16%, signal=33% LYMPHOCYTE_DIFFERENTIATION 25 0.514 1.544 0.026 0.204 1 2617 tags=40%, list=15%, signal=47% DAC_PANC_UP 351 0.327 1.536 0 0.205 1 2550 tags=25%, list=15%, signal=28% EPIDERMIS_DEVELOPMENT 64 0.415 1.538 0.011 0.205 1 3237 tags=31%, list=18%, signal=38% HDACI_COLON_BUT24HRS_UP 59 0.418 1.537 0.014 0.205 1 2692 tags=31%, list=15%, signal=36% TOB1PATHWAY 18 0.55 1.541 0.046 0.205 1 2110 tags=39%, list=12%, signal=44% MAMMARY_DEV_UP 53 0.434 1.538 0.022 0.206 1 3688 tags=38%, list=21%, signal=48% REPRODUCTIVE_PROCESS 138 0.361 1.529 0 0.211 1 3890 tags=38%, list=22%, signal=49% DORSEY_DOXYCYCLINE_UP 30 0.491 1.53 0.03 0.211 1 2343 tags=33%, list=13%, signal=38% BASSO_GERMINAL_CENTER_CD40_DN 61 0.411 1.53 0.011 0.212 1 2423 tags=33%, list=14%, signal=38% ZHAN_MMPC_SIMAL 45 0.431 1.527 0.02 0.212 1 4799 tags=51%, list=27%, signal=70% LIPID_RAFT 25 0.493 1.527 0.036 0.212 1 3333 tags=44%, list=19%, signal=54% CYTOKINEPATHWAY 20 0.529 1.526 0.044 0.212 1 756 tags=30%, list=4%, signal=31% HSA04340_HEDGEHOG_SIGNALING_PATHWAY 54 0.423 1.531 0.01 0.213 1 3149 tags=26%, list=18%, signal=32% LU_IL4BCELL 66 0.41 1.524 0.022 0.213 1 3602 tags=38%, list=21%, signal=48% KANG_TERT_DN 92 0.377 1.521 0.002 0.214 1 3412 tags=35%, list=19%, signal=43% ROS_MOUSE_AORTA_DN 73 0.4 1.522 0.016 0.215 1 2453 tags=25%, list=14%, signal=29% BIOGENIC_AMINE_SYNTHESIS 16 0.556 1.521 0.04 0.215 1 3294 tags=44%, list=19%, signal=54% RESPONSE_TO_OTHER_ORGANISM 70 0.398 1.521 0.022 0.216 1 4293 tags=41%, list=25%, signal=55% CHIARETTI_T_ALL 226 0.335 1.512 0.003 0.225 1 3500 tags=32%, list=20%, signal=39% ION_HOMEOSTASIS 116 0.362 1.51 0.009 0.225 1 2418 tags=28%, list=14%, signal=33% CHANNEL_REGULATOR_ACTIVITY 22 0.52 1.513 0.034 0.225 1 1300 tags=23%, list=7%, signal=25% EICOSANOID_SYNTHESIS 18 0.554 1.51 0.045 0.226 1 1632 tags=39%, list=9%, signal=43% EXTRACELLULAR_REGION 413 0.313 1.507 0 0.228 1 2596 tags=26%, list=15%, signal=29% ET743_SARCOMA_6HRS_UP 28 0.476 1.498 0.048 0.228 1 1533 tags=21%, list=9%, signal=23%

    HOUSTIS_ROS 31 0.472 1.506 0.05 0.228 1 3521 tags=35%, list=20%, signal=44% IMMUNE_SYSTEM_PROCESS 300 0.324 1.5 0 0.229 1 2854 tags=26%, list=16%, signal=31% UV-CMV_UNIQUE_HCMV_6HRS_UP 96 0.378 1.507 0.011 0.229 1 2393 tags=22%, list=14%, signal=25% HPV31_UP 52 0.418 1.498 0.026 0.229 1 701 tags=12%, list=4%, signal=12% LEUKOCYTE_DIFFERENTIATION 36 0.454 1.505 0.041 0.229 1 2617 tags=36%, list=15%, signal=42% FERRARI_4HPR_UP 22 0.505 1.499 0.031 0.23 1 4400 tags=55%, list=25%, signal=73% RAS_ONCOGENIC_SIGNATURE 235 0.331 1.5 0.002 0.233 1 2424 tags=22%, list=14%, signal=25% DER_IFNG_UP 59 0.402 1.489 0.03 0.236 1 3449 tags=31%, list=20%, signal=38% BRENTANI_IMMUNE_FUNCTION 50 0.422 1.489 0.031 0.236 1 2936 tags=32%, list=17%, signal=38% LEE_TCELLS6_UP 22 0.506 1.488 0.044 0.236 1 1967 tags=27%, list=11%, signal=31% ROSS_MLL_FUSION 70 0.392 1.49 0.027 0.237 1 4640 tags=37%, list=26%, signal=50% RECEPTOR_COMPLEX 51 0.423 1.49 0.03 0.238 1 2534 tags=31%, list=14%, signal=37% TAKEDA_NUP8_HOXA9_16D_DN 194 0.338 1.49 0 0.239 1 2853 tags=27%, list=16%, signal=32% IL6_FIBRO_UP 43 0.432 1.491 0.043 0.239 1 3081 tags=37%, list=18%, signal=45% EGF_HDMEC_UP 41 0.44 1.485 0.031 0.24 1 4691 tags=49%, list=27%, signal=66% IMMUNE_EFFECTOR_PROCESS 32 0.462 1.484 0.034 0.241 1 3918 tags=47%, list=22%, signal=60%

    FWER Rank at Gene Set (Down-Regulated) Size ES NES NOM p-val FDR q-val p-val Max Leading Edge ZHAN_MM_CD138_PR_VS_REST 36 -0.643 -2.253 0 0.002 0.002 4544 tags=69%, list=26%, signal=94% SERUM_FIBROBLAST_CELLCYCLE 115 -0.502 -2.182 0 0.003 0.007 4541 tags=55%, list=26%, signal=73% CELL_CYCLE_PROCESS 162 -0.472 -2.164 0 0.003 0.01 4726 tags=48%, list=27%, signal=65% M_PHASE_OF_MITOTIC_CELL_CYCLE 68 -0.521 -2.068 0 0.014 0.065 2441 tags=37%, list=14%, signal=43% MITOSIS 65 -0.524 -2.071 0 0.016 0.063 2441 tags=37%, list=14%, signal=43% CROONQUIST_IL6_STARVE_UP 32 -0.59 -1.988 0.002 0.027 0.199 4085 tags=66%, list=23%, signal=85% M_PHASE 95 -0.482 -2.007 0 0.028 0.156 2441 tags=36%, list=14%, signal=41% CELL_CYCLE_PHASE 142 -0.454 -1.997 0 0.028 0.181 4726 tags=48%, list=27%, signal=65% P21_P53_ANY_DN 42 -0.553 -1.961 0 0.032 0.281 5100 tags=67%, list=29%, signal=94% MITOTIC_CELL_CYCLE 125 -0.447 -1.966 0 0.033 0.264 4726 tags=45%, list=27%, signal=61% LEE_TCELLS3_UP 90 -0.47 -1.949 0 0.035 0.322 4631 tags=54%, list=26%, signal=74% IDX_TSA_UP_CLUSTER3 82 -0.473 -1.943 0 0.036 0.35 6237 tags=63%, list=36%, signal=98% BRENTANI_REPAIR 37 -0.549 -1.896 0 0.056 0.514 5418 tags=57%, list=31%, signal=82% MICROTUBULE_CYTOSKELETON 125 -0.429 -1.864 0 0.078 0.669 3598 tags=38%, list=21%, signal=47% CELL_CYCLE_CHECKPOINT_GO_0000075 40 -0.536 -1.853 0 0.082 0.709 5211 tags=68%, list=30%, signal=96%

    GOLDRATH_CELLCYCLE 26 -0.572 -1.845 0.002 0.083 0.731 4085 tags=50%, list=23%, signal=65% MICROTUBULE_ORGANIZING_CENTER 57 -0.477 -1.834 0.004 0.084 0.772 4311 tags=49%, list=25%, signal=65% DNA_REPAIR 107 -0.424 -1.827 0 0.087 0.799 6101 tags=54%, list=35%, signal=83% CHOLESTEROL_BIOSYNTHESIS 15 -0.683 -1.834 0.006 0.089 0.772 5131 tags=80%, list=29%, signal=113% DOX_RESIST_GASTRIC_UP 39 -0.513 -1.773 0.006 0.124 0.946 4996 tags=56%, list=29%, signal=79% CROONQUIST_IL6_RAS_DN 22 -0.571 -1.785 0.015 0.126 0.925 4491 tags=64%, list=26%, signal=85% SPINDLE 35 -0.528 -1.775 0 0.127 0.943 3598 tags=51%, list=21%, signal=65% CHROMOSOME__PERICENTRIC_REGION 26 -0.547 -1.776 0.002 0.131 0.942 4850 tags=54%, list=28%, signal=74% RNA_HELICASE_ACTIVITY 21 -0.591 -1.76 0.002 0.132 0.959 5199 tags=71%, list=30%, signal=101% PROTEIN_DNA_COMPLEX_ASSEMBLY 35 -0.502 -1.746 0.002 0.134 0.969 4207 tags=46%, list=24%, signal=60% HELICASE_ACTIVITY 42 -0.488 -1.761 0 0.137 0.959 5719 tags=60%, list=33%, signal=88% P21_P53_MIDDLE_DN 21 -0.586 -1.747 0.007 0.138 0.969 5100 tags=67%, list=29%, signal=94% IDX_TSA_DN_CLUSTER6 22 -0.567 -1.75 0.006 0.14 0.967 4211 tags=50%, list=24%, signal=66% DNA_HELICASE_ACTIVITY 18 -0.599 -1.736 0.008 0.143 0.977 5719 tags=67%, list=33%, signal=99% REGULATION_OF_SMALL_GTPASE_MEDIATED_SIG

    NAL_TRANSDUCTION 22 -0.555 -1.713 0.002 0.162 0.996 2407 tags=27%, list=14%, signal=32% REGULATION_OF_MITOSIS 35 -0.51 -1.715 0.004 0.164 0.995 5004 tags=54%, list=29%, signal=76% NUCLEOTIDE_METABOLISM 16 -0.609 -1.717 0.006 0.167 0.993 3352 tags=56%, list=19%, signal=69% CELL_CYCLE_GO_0007049 274 -0.345 -1.705 0 0.168 0.997 5004 tags=42%, list=29%, signal=58% CENTROSOME 49 -0.465 -1.686 0.002 0.185 0.999 4311 tags=49%, list=25%, signal=65% CHROMOSOME_SEGREGATION 22 -0.556 -1.687 0.002 0.188 0.999 4850 tags=55%, list=28%, signal=75% VERNELL_PRB_CLSTR1 58 -0.44 -1.688 0.002 0.192 0.999 6063 tags=57%, list=35%, signal=87% MITOTIC_CELL_CYCLE_CHECKPOINT 18 -0.575 -1.678 0.014 0.193 0.999 2441 tags=44%, list=14%, signal=52% HOFFMANN_BIVSBII_BI_TABLE2 181 -0.368 -1.663 0 0.215 1 3804 tags=36%, list=22%, signal=45% SPINDLE_POLE 17 -0.579 -1.659 0.009 0.217 1 2711 tags=53%, list=15%, signal=63% INTERPHASE 57 -0.443 -1.653 0.007 0.224 1 4726 tags=44%, list=27%, signal=60% INTERPHASE_OF_MITOTIC_CELL_CYCLE 54 -0.435 -1.638 0.002 0.231 1 4726 tags=43%, list=27%, signal=58% HDACI_COLON_CLUSTER10 38 -0.476 -1.64 0.011 0.232 1 5325 tags=47%, list=30%, signal=68% KINETOCHORE 21 -0.549 -1.63 0.015 0.236 1 2496 tags=33%, list=14%, signal=39% YU_CMYC_UP 29 -0.492 -1.641 0.015 0.236 1 5093 tags=52%, list=29%, signal=73% SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 66 -0.412 -1.63 0.005 0.241 1 5234 tags=45%, list=30%, signal=65% DAMAGED_DNA_BINDING 17 -0.562 -1.642 0.022 0.241 1 5211 tags=65%, list=30%, signal=92% MANALO_HYPOXIA_DN 82 -0.391 -1.618 0.007 0.242 1 5486 tags=46%, list=31%, signal=67%

    MICROTUBULE_BINDING 27 -0.497 -1.611 0.015 0.242 1 3247 tags=41%, list=19%, signal=50% DNA_REPLICATION_REACTOME 46 -0.443 -1.613 0.011 0.243 1 6652 tags=59%, list=38%, signal=94% CPR_LOW_LIVER_UP 16 -0.576 -1.614 0.018 0.244 1 4873 tags=56%, list=28%, signal=78% CELL_CYCLE_KEGG 87 -0.395 -1.618 0.002 0.246 1 5302 tags=52%, list=30%, signal=74% HSA00562_INOSITOL_PHOSPHATE_METABOLISM 42 -0.447 -1.606 0.014 0.247 1 4954 tags=57%, list=28%, signal=79% MOTOR_ACTIVITY 25 -0.512 -1.604 0.025 0.247 1 2994 tags=52%, list=17%, signal=63% CELL_CYCLE 78 -0.396 -1.619 0 0.248 1 5302 tags=49%, list=30%, signal=70%

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