222 cases of bilateral primary breast cancer prognostic factors
【Abstract】 Objective To study the bilateral primary breast cancer (Bilateral Primary Breast Cancer, BPBC) and its prognostic factors. Methods of Tianjin Medical University
Cancer Hospital in March 1972 ~ December 2003 admitted to 222 BPBC clinical data of patients with prognostic factor analysis. Results BPBC The 5,10-year cumulative survival rates
were 78.73%, 69.09%. sBPBC the overall survival rates compared
with mBPBC difference, but no statistical significance. The first side of node-positive result, and the second side of node-positive result, and the second side of tumor size, histological grading of the second side of the role of survival was statistically significant. Conclusion At the same time and the survival rate of metachronous BPBC similar. The second side of tumor ? 5cm, bilateral lymph node-positive
poor prognosis. Multivariate analysis showed that the second side of tumor size and the first side, second side with lymph
node-positive factors influencing the prognosis.
Key words bilateral primary breast cancer; prognosis; survival rate
Prognostic of 222 Cases Bilateral Primary Breast Cancer
Abstract: Objective To evaluate the outcome and prognosis
analyze of bilateral primary breast cancer (BPBC). Methods The
clinical data of 222 patients with BPBC, admitted to Tianjin Medical University Cancer Institute and Hospital from March 1972 to December 2003 were collected and analyzed on prognosis
factors. Results 5 year and 10 year Cumulative Survival
rate of BPBC were 78.73% and 69.09%. Cumulative Survival rate of sBPBC (Synchronous BPBC, sBPBC) is lower than mBPBC's (Metachronous BPBC, mBPBC), but there is no significant difference . The status of bilateral lymph node of and tumor size of secondary cancer affect the survival of BPBC significantly. Conclusion The survival rate of sBPBC is similar to that of mBPBC. The prognosis of patients with negative lymph node of two sides and tumor size <5cm of
secondary cancer are better than those with positive lymph node and tumor size ? 5cm. The results of multivariate
analysis showed that tumor size of secondary cancer and lymph node status ofbilateral breast cancer are prognostic factors of bilateral primary breast cancer.
Key words: Bilateral breast cancer; Prognostic analysis; Survival Rate
As the breast is subject to the role of female hormones affect the symmetry of the target organ, the possibility of
cancer occurring on both sides, and the side of the breast disease, the contralateral breast as the only target organ, so the possibility of a marked increase in cancer occurrence , that is, unilateral breast cancer patients have a high risk of development of bilateral breast cancer. Donovan  through the study found that the side of the risk of breast cancer, the contralateral breast recurrence risk of new breast cancer was 5 times higher than the general population. Pomerantz et al  reported that the side contralateral breast cancer
occurrence in patients with cancer whose chances of women in the census 2 ~ 7 times. With the Breast Cancer Detection and Diagnosis and treatment advances in technology improvements in survival in patients with unilateral breast cancer patients
generally longer on one side contralateral breast cancer after treatment of breast cancer occurring opportunities are also increasing. Bilateral primary breast cancer pairs (Bilateral
Primary Breast Cancer, BPBC) the incidence of a majority in
the country reported at 2.1% or less , the highest 4.97% . Currently in the country on the primary bilateral breast cancer survival rates vary widely reported, and the mostly small sample of relevant research findings, a larger number of
cases is still a lack of information in support of the longer follow-up observation of the multi-factor analysis of the
systematic study of . To this end, we Tianjin Medical University Cancer Hospital admitted 222 cases of BPBC clinical data and follow-up results of the prognostic factor analysis, the results reported as follows.
An object and method
1.1 The object of study
March 1972 ~ December 2003 pairs of bilateral primary breast cancer were treated 222 cases of breast cancer patients, both female, aged 26 to 95 years old, with a median age of 45.55 years with a mean age of 47.27 years. Survival years from the start to the second side of the day of surgery until death, recurrence, metastasis or last follow-up time.
The two breast cancer interval calculation, using the second admission date to the date of the first operation time interval shall prevail.
1.2 Case inclusion criteria
(1) on both sides have surgery. (2) side or the second side to check the ingredients, see carcinoma in situ, that is,
or possession of lobular carcinoma in situ component. (3) The second occurred in the first lateral side of at least five years after treatment, and no other distant parts of the transfer, but also consider the primary lesion. (4)
Organization Type: both sides of the breast cancer tissue types are completely different.
1.3 Statistical Methods
Application of SPSS11.5 statistical package used for statistical analysis of survival using Kaplan Meier's
method, the analysis of prognostic factors using Cox univariate and multivariate analysis of prognostic factors of grouping data using Kaplan Meier method and Log Rank
test done .
2.1 The incidence of
As of the end of December 2003, in the cancer hospital admissions over the same period, 20 308 breast cancer patients found 222 cases of BPBC patients, BPBC incidence of patients was 1.09%, of which pairs of simultaneous bilateral primary breast cancer (Synchronous Bilateral Primary Breast Cancer, sBPBC) 69 cases, the incidence of 0.34%, metachronous bilateral primary pairs of breast cancer (Metachronous Bilateral Primary Breast Cancer, mBPBC) 153 cases, incidence rate of 0.75%.
Follow-up to early April 2006, 49 cases of death due to cancer, 49 cases had distant metastases. The shortest follow-