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Study_3

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Study_3

    Study

;Vo1.16.No.1CHINESEMEDICALSCIENCESJOURNAL55

    ;4.LiuHG,HuaB,DaiW,eta1.Spirochetesinthecheilitis8.ZhuYX.WangY,HeX,eta1.Cheilitisgranulomatosaand

    ;granulomatosaandsarcoidosis.NatlMedJChina,1993,73MelkerssonRo

    senthalsyndrome.ChinJStomatol,1985,20

    ;(3):142.(4):345.

    ;5.HuaB,LiQL,WangFM,eta1.BorreliaBurgdolferiinfection9.WangHQ,LiRW,WangZY,eta1.Cheilitisanu1omatosa.

    ;maybethecauseofsarcoidosis.ChinMedJ,1992,105(7):ChinJStomatol,1984,19(2):112.

    ;560.10.NakashimaT,MalluoS,WyedaA,eta1.0demgebundene ;6.LiuHG,ZhengLF,WuQG,eta1.Histopathologicalresearchganulomatosis:reportofacase.ClinDermatol,1990,32(9):

    ;ofcheilitisgranulomatosaof59cases.ChinJStomatol,1994,1177. ;29(2):198.11.ChenQc.Spirochetesdiseases.In:BatXQ(ed).Pathology.2nd ;7.?

    uHG,ZhengLF,YuSF,eta1.MelkerssonRosenthalsyned.Beijing:Scienc

    ePublishingPress,1987;459.

    ;drome:clinicalpathologicalstudyof89cases.ModStomatol, ;1994,8(1):6.

    ;StudyofTCellReceptorGeneRearrangementsin

    ;PatientswithMyastheniaGravis

    ;GaoFeng(高枫),LiXiaodong(李晓东)andChenQingtang(陈清棠)

    ;DepartmentofNeurology,TheFirstTeachingHospitalofPekingUniversity,Beijing100034

    ;Tcellreceptors(TCR)areacollectionofseveralpatients.Allthefourpatientshadbeenfoundtohave

    ;proteinslocatedintheoutermembraneoftheTcel1.thymoma,ofwhich2werelymphocyteand2mixedtype.

    ;MatureTcellhasdefinitiveTCRgenes,whichmaybeButrearrangedbandscouldnotbedetectedintheDNAs

    ;usedasaclonalmarker.ToinvestigatewhetherTCRgeneofanotherfourpatientswiththymoma,ofwhich2were

    ;analysismaybeusefulfordiagnosisofmyastheniagravisepithelialand2mixedtype.WhenDNAwasdigestedwith

    ;(MG)withthymoma,weusedthecDNAofthepsub-HindlIIandBglII,ger

    mlinebandsappearedinDNAsfrom

    ;unitoftheTCRservedasprobestoanalyzethestructureallpatients.Norearrangedbandscouldbeobserved.Single

    ;oftheTCRBgeneandtodeterminetheextentofdiversityrearrangedbandswer

edetectedinfourpatientswiththy.

    ;betweenMGwiththymomaandMGwithoutthymoma.moma,thisshowedthatspecificTCRgenerefirrangement

    ;Eighteenpatientswereclinicallydiagnosedgeneralizedmayberelatedtocertaintypesofthymoma.Detectionof

    ;MG,eightofthemhadthymoma.Peripheralbloodlym-TCRgenerearrangementmightbehelpfultotheearly

    ;phocytes(PBL)wereobtainedatorshortlybeforediagnosisofMGwiththymoma.Butwewereunableto

    ;thymectomy(exceptone,2yearsafterthymectomy).findgenerearrangementinanotherfourthymoma(2were

    ;WhenDNAwasdigestedwithEcoRIandhybridizedwithepithelialand2mixedtype).Therearethreepossible

    ;thePlabeledprobes,twogermlinebandsof10.5kbandexplanationsfortheresults.First,thymomahashetero.

    ;4.0kbappearedinDNAsfromall18patients.The10.5geneity.Second,TCRgenerearrangementonlyreflects

    ;kbbandcontainstheCB1regionandthe4.0kbfragmenttheclonaloriginoftheTcelltumor.Third,inonepa-

    ;theCB2region,respectively.The4.0kbbandisUSU-tient,peripheralbloodlymphocyteswereobtainedtwo

    ;allyreducedascomparedwiththe10.5kbband.Thiscanyearsafterthymecto

my,neoplasticTcellsmaybedisap.

    ;beexplainedbythepreferentialrearrangementoftheCBpear.Thus,ourresultssuggestedthatTCRgenerear-

    ;2geneinTcellwithMG.WewereabletodemonstratearangementinpatientswithMGmaybehelpfulfordiag.

    ;rearrangedbandof9kbinEcoRI--digestedDNAsoffournosingcertaintypeofthymoma.

    ;}

    ;_豳隧l蕊豳碧_?鬣露戮羞

    ;

    ;

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