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Dr - Analyzed the Quality Control/Assurance s

By Troy Gordon,2014-05-19 20:19
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Analyzed the Quality Control/Assurance system and made recommendations for improvements. These were incorporated into the current Quality Assurance System.

Dr. Ghias Uddin

    Ph.D. (PK). Organic Chemistry

    AIST-ITIT (Japan), STA (Japan)

    Res. Associate: Dept. of Medicine, Neurology

    Division, University of Alberta, Canada

    Foreign Professor

    Institute of Chemical Sciences

    Department of Chemistry

    University of Peshawar, Peshawar

    Pakistan Contact:

     Phone: (+92)-91-9216652

     Cell: (+92)-03453256686

    E-mail: Ghiasuddin@upesh.edu.pk

     drghiasuddin@hotmail.com

    ? Current Research Interests: Include isolation, identification and

    characterization of bioactive natural products from traditional medicinal

    herbs/plants to develop biosynthesis of natural products and microbial

    transformations of bioactive chemical constituents and determine their structure-

    activity relationship by advanced chromatographic and spectroscopic techniques

    especially one- and two- dimensional NMR, mass spectrometry, UV and IR

    spectrophotometer. The pure chemical compounds and various fractions of extract

    are examined to discern their modes of action, and biological activity; anti-

    microbial, anti-viral, anti-malarial, anti-cancer, anti-HIV, anti-inflammatory, anti-

    diabetic, anti-oxidant, and lipoxygenase-inhibition activity etc.

     Objects:

    ? To isolate/synthesize new pharmaceutical compounds from natural sources such

    as traditional medicinal herbs/plants, marine organisms, and microorganisms to

    develop biosynthesis of natural products and microbial transformations of

    bioactive natural products and determine their structure-activity relationship using

    by various analytical/chromatographic techniques; such as column

    chromatography, high performance liquid chromatography (HPLC), gas

    chromatography (GC) and thin/thick layer chromatography (TLC), bio-gel

    column chromatography and the structure of the pure secondary metabolites is 1established with the aid of extensive spectroscopic studies: one-dimensional (H-13NMR, C-NMR, DEPT, NOE), two-dimensional (COSY, NOESY, TOCSY,

    HMQC, HMBC) NMR experiments, mass spectrometry (EI, CI, FAB, FD, GC-

    MS, and linked scan), UV and IR spectrophotometer and characterize pure

    chemical constituents are examined to discern their modes of action, and

    biological activity; anti-microbial, anti-viral, anti-malarial, anti-cancer, anti-HIV,

    anti-inflammatory, anti-diabetic, anti-oxidant, and lipoxygenase-inhibition

    activity and Neuroprotective actions etc. Their potential application as novel

    medicinal agents into the basic research of life sciences and standardize as

    clinically useful medications.

? To establish an institutional committee competent to oversee the institution's

    animal program, facilities, and projects involving the use of animals. This

    committee has been designated as the Institutional Animal Care and Use

    Committee (IACUC). Carrying out meaningful scientific research through the use

    of laboratory animals in accordance with humane standards under the provisions

    of the Public Health Service Policy.

    Profile:

    ? As a chemist with wide range of experience in the Pharmaceutical and Medical

    research field, able to work on own initiative and as a part of a team member.

    Proven leadership skills, involving managing, developing, and motivating teams

    to achieve their objectives. Have a first-class analytical designing techniques and

    problem solving skills. Dedicated to maintaining high quality of research

    standards and capable to learn techniques those are more advanced.

    Professional Trainings:

? “Hydrocarbon Fluid Properties and Processing”

     University of Alberta, Edmonton, AB, Canada

    ? “The care and use of Animals in Research, Teaching and Testing”

     Health Sciences Animal Policy and Welfare Committee, University of Alberta,

     Edmonton, AB Canada.

    ? The Care and use of the Laboratory Rats

     Health Sciences Animal Policy and Welfare Committee, University of Alberta,

     Edmonton, AB Canada.

    Major Achievements:

    ? 45 Research Publications.

    ? Co-supervised: Ph.D. Scholars: Mr. M. Rasheed (Azadirachta indica A. Juss.), F.

    Afshan (Azadirachta indica A. Juss.) and R. Noor (Neuro-protection and

    thrombolysis: Neuro-Science University of Alberta Canada). M. Phil. Scholar: S.

    Ahmed (Atripleex stocksii Bios.) and Graduate Student: A. Nasir (Neuro-Science

    University of Alberta Canada).

    ? Increased the acceptance level of finished products from 95% to 99%.

    ? Solved major Quality Assurance problems, which temporarily halted production.

    ? Successfully developed, and formulated new products and documented their SOP.

    ? Successfully documented Institutional Bio-safety Protocol.

    Professional Experiences and Responsibilities:

    04/2006 Present Foreign Professor

    Institute of Chemical Sciences, Department of Chemistry,

    University of Peshawar, Peshawar, Pakistan

    Tel: (+92)-091-9216652, Fax: (+92)-091-9216652 ? To carrying out research along with teaching.

? Prepare course materials such as syllabi, homework assignments, and handouts

    and deliver lectures to graduate and postgraduate students on topics such as

    organic chemistry, and Natural Products Chemistry.

Course: M. Sc. Organic Chemistry

     Oxidation / Reduction

     Heterocyclic / Natural Products Chemistry.

     Course: M. Phil. & Ph.D.

     CHEM-764: Organic Name Reactions and Synthetic Reagents.

    ? Supervise Students' / Research Scholars

     Five Ph. D. (HEC Indigenous Scholars)

     (Research Area: Natural Products/Synthesis)

     M. Sc. (Final) Research Projects:

     (Research Area: Natural Products)

    08/2001 3/2006 Research Associate

    Department of Medicine, Division of Neurology, Stroke Research

    EPC Lab.533 HMRC, University of Alberta, Edmonton, AB,

    T6G 2S2, Canada. Tel: (780)-492-7503, Fax: (780)-492-1617 ? Neuro-protection and thrombolysis in ischemic brain injury.

    ? Patency of cerebral micro-vessels after focal embolic stroke in the rats.

    ? Proficient in cryostat and fluorescent microscopy.

    ? Endothelial Progenitor cells and their vascular function-to repair the endothelial

    dysfunction.

    ? Endothelial Progenitor cells culture, separation of mononuclear cells and plasma

    from peripheral blood.

    ? Immunostaining of Endothelial Progenitor Cells culture.

    09/1998 08/2001 Assistant Quality Control Manager

    Hilton Pharma (PVT) Ltd., Karachi, Pakistan

    ? Managed all Quality Control/Assurance.

    ? Products development, formulation, conducted their chemical experiments and

    documented new products SOP.

    ? Formulated new product lines and conducted the relevant laboratory experiments.

    ? Analyzed the Quality Control/Assurance system and made recommendations for

    improvements. These were incorporated into the current Quality Assurance

    System.

    ? Ensured that stability of different products and chemical testing for validation

    purposes.

    ? Documented of Institutional Bio-safety Protocol and followed up safety protocol

    compliance.

     Senior Research Associate 01/1997 09/1998

    HEJ Research Institute of Chemistry, University of Karachi,

    Pakistan.

    ? Structure elucidation and characterization (using GC-MS, UV, IR Spectroscopy, 113EI, FAB-Mass, 1D, and 2D-NMR (H-C-NMR) Spectroscopy) of isolated and

    synthesized chemical substances.

    ? Designed New Research Projects.

    ? Supervised M. Phil. and Ph.D. Research Scholars.

    01/1996 01/1997 STA-Japan (Guest Research Fellow)

     Osaka National Research Institute, Ikeda, Osaka, Japan.

    ? Cultivation of Botryococcus braunii bacteria cells, Extraction, DNA Purification,

    Electrophoresis, PCR, Cloning transformation, and synthesis of hydrocarbon

    (Botryococcen).

    03/1995 01/1996 Research Associate

    HEJ Research Institute of chemistry, University of Karachi,

    Karachi, Pakistan.

    ? Extraction, Isolation and Purification of chemical substances from medicinal

    plants & herbs and also synthesized their biologically active analogues.

    ? Structure elucidation and characterization (by using GC-MS, UV, IR 113Spectroscopy, EI, FAB-Mass, 1D, 2D-NMR (H C) Spectroscopy) of isolated

    and synthesized chemical substances.

03/1994-03/1995 AIST-ITIT- Japan (Guest Research Fellow)

     Shikoku National Industrial Research Institute, Takamatsu, Japan.

    ? Extraction, Isolation, Purification and Characterization of Lipopolysaccharide and

    related chemical constituents of Cyanobacteria.

    ? Cultivation of Cyanobacteria cells, Bio gel P-2 Column Chromatography,

    Lyophilization and Centrifugation, SDS-polyacrylamide Gel electrophoresis, SDC

    (Scanning Differential Calorimeter), HPLC, GC-MS, FAB-Mass Spectroscopy 113and H-C- NMR Spectroscopy, AFM (Atomic force Microscope) and QCM

    (Quartz Crystal Microbalance).

Computer Skills:

    ? Microsoft Word, Excel, PowerPoint, Internet Explorer.

    ? Chromatography, Spectroscopy and chemical structure drawing database.

    ? Chemical Database: Chemical inventory and tracking.

    ? Scientific Graphics Database: Designed to generate analytical control charts.

    ? Laboratory Management Database: Instruments maintenance, calibration and

    laboratory documentations.

Academic Qualifications:

    ? Ph. D. Organic Chemistry (Awarded 1995)

    HEJ Research Institute of Chemistry, University of Karachi Pakistan

    „Thesis Title: “Chemical Studies on the Constituents of Azadirachta Indica A. Juss.”

    ? M. Sc. (Organic Chemistry)

    University of Karachi, Karachi, Pakistan

    ? B. Sc. (Chemistry)

    University of Karachi, Karachi, Pakistan

    Personal Detail:

     Date of Birth: September 24, 1960

    Marital Status: Married

     Nationality: Canadian and Pakistani

     Children: one

     Selected Research Publications:

    o Samer Aldandashi, Raza Noor, Chen Xu Wang, Ghias Uddin and Ashfaq

    Shuaib (2007). Combination treatment with dipyridamole, aspirin, and tPA in an

    embolic model of stroke in rat. Experimental Neurology., 205, 563-568. o Ghias Uddin, A. Shuaib, M. Hussain, A. Nasir, S. Aldandashi and R. Noor

    (2004). Adjuvant Treatment with Glyco-Protein IIb/IIIa Antagonist Reduces

    Perfusion Deficits and Improves Cerebral Blood Circulation after Middle

    Cerebral Artery Occlusion in Rat Model of Embolic Stroke. J. Pharmaceut. Sci.

    7(2), 55-56.

    o Ghias Uddin, M. Hussain, Chen Xu Wang, Kathryn G. Todd and Ashfaq Shuaib

    (2003) Acetylsalicylic acid reduces perfusion deficit in ischemic injured brain in

    the rats. J. Neuro Report., 14(13), 1753-1755.

    o Bina S. Siddiqui, Ghiasuddin, S. Faizi and M. Rasheed (2000). Biologically

    Active Triterpenoids of Biogenetic interest from the fruit coats of Azadirachta

    indica., Tetrahedron., 56, 3547-3551.

    o Bina. S. Siddiqui, F. Afshan, Ghiasuddin, S. Faizi, S.N.H. Naqvi, R.M. Tariq

    (2000). Two insecticidal Tetranortriterpenoids from Azadirachta indica,

    Phytochemistry., 53, 371-376.

    o Bina. S. Siddiqui, F. Afshan and Ghiasuddin (1999). Meliacinolide and

    Meliacinol, two new tetracyclictriterpenoids from the fresh leaves of Azadirachta

    indica A. Juss. J. Chem. Soc. Perkin Trans 1, 2367 2370. o Bina. S. Siddiqui, Ghiasuddin, S. Faizi and M. Rasheed (1999). Triterpenoids of

    the Fruit coats of Azadirachta indica, J. Nat. prod., 62, 1006-1009. o Bina S. Siddiqui, Ghiasuddin, S. Faizi (1998). Tetracyclictriterpenods from the

    fruit coats if Azadirachta indica. Phytochemistry, 47, 1631 1636. o B.S. Siddiqui, S. Ahmed, Ghiasuddin and Atta-Ullha Khan (1994). Constituents

    of Atripleex stocksii Bios., Phytochemistry, 37, 1123-1125.

    o Bina S. Siddqui, Ghiasuddin, S. Faizi and S. Siddiqui (1992). Triterpenoids

    from the fresh fruit coats of Azadirachta indica., Phytochemistry, 31, 4275-4278. o S. Siddiqui, S. Faizi, Bina S. Siddiqui and Ghiasuddin (1992). Constituents of

    Azadirachta indica (Meliaceae)-isolation and structure elucidation of a new

    antibacterial teteranortrterpenoid, Mahmoodin and a new protolimonoid,

    Naheedin. J. Nat Prod. 55, 303-310.

    o S. Siddiqui, Bina S. Siddiqui, Ghiasuddin and S. Faizi (1991). Terpenoids from

    the fruit coatings of Azadirachta indica. Phytochemistry, 30, 1615-1619. o S. Siddiqui, Bina S. Siddiqui, Ghiasuddin and S. Faiz (1991). Tetracyclic

    triterpenoids of the fruit coats of Azadirachta indica., J. Nat. Prod., 54, 408-415.

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