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    Song Yi, Ph.D.

    Postdoctoral Research Scholar

    Department of Biology

    The University of Iowa

    314 Biology Building East

    Iowa City, IA 52242

    Tel.: 319-335-1116 E-mail: song-yi@uiowa.edu

EDUCATION

    ? Ph.D. in Biology at the University of Iowa, Iowa City, IA Aug.2003-Jul.2009

    Dissertation: A unique relationship between switching, mating and biofilm formation in the

    human pathogen Candida albicans

    Advisor: Dr. David R. Soll (Roy J. Carver/Emil Witschi Professor; Director of W.M. Keck

    Dynamic Image Analysis Facility and Director of Developmental Studies

    Hybridoma Bank, DSHB)

    ? B.S. in Biological Sciences at Peking University, Beijing, China Sep.1999-Jul.2003

    Thesis: Plasticity of neuropeptide Y in the central nervous system of ground squirrel

    (Citellus dauricus) during hibernation

    Advisor: Dr. Long-Chuan Yu (Vice Director of State Key Laboratory of Biomembrane and

    Membrane Biotechnology, China)

PROFESSIONAL EXPERIENCE

    2009- Postdoctoral Research Scholar, Department of Biology, the University of Iowa, Iowa

    City, IA

    ? Investigating the targets of the transcription factor Tec1 by ChIP-chip analysis in

    yeast.

    2003-2009 Graduate Research Assistant, Department of Biological Sciences, the University of

    Iowa,Iowa City, IA

    ? Established a transcription factor misexpression library to explore unique regulators

    in biofilm development.

    ? Proficient in molecular biology, including Southern, Northern and Western blot,

    SDS-PAGE, RT-PCR, FACS, microarray analysis, and transfection of cells by

    electroporation.

    ? Familiar with bioinformatic programs, hierarchical clustering dendrograms, and

    phosphorylation and ubiquitination analyses.

    ? Proficient in imaging techniques, including DIC and fluorescence microscopy,

    confocal and multi-photon microscopy, and scanning electron microscopy. 2001-2003 Research Assistant, State Key Lab of Biomembrane and Membrane Bioengineering,

    Beijing, China

    ? Performed independent neuroscience thesis projects in rats and ground squirrels.

    ? Proficient in neural cell culture, immunohistochemistry, rat dissection and

    cryo-sectioning, antibody generation and purification, ELISA, and behavioral

    pharmacology.

     Song Yi, Ph.D. (Updated Sep., 2009)

    PUBLICATIONS

    Research Articles:

    1. Sahni, N., Yi, S., Daniels, K.J., Srikantha, T., Soll, D.R. (2009). Genes selectively up-regulated

    by pheromone in white cells are involved in biofilm formation in Candida albicans. PLoS

    Pathog. In press.

    2. Yi, S., Sahni, N., Pujol, C., Daniels, K.J., Srikantha, T., Ma, N., Soll, D.R. (2009). A Candida

    albicans-specific region of the α-pheromone receptor plays a selective role in the white cell

    pheromone response. Mol. Microbiol. 71, 925-947.

    3. Huang, G., Yi, S., Sahni, N., Daniels, K.J., Srikantha, T., Pujol, C., Soll, D.R. (2009).

    N-acetylglucosamine induces white to opaque switching through the cAMP pathway in Candida

    albicans. PLoS Biol. submitted.

    4. Sahni, N., Yi, S., Soll, D.R. (2009). The white cell response to pheromone is a general

    characteristic of Candida albicans strains. Eukaryot. Cell 8, 251-256.

    5. Huang, G., Srikantha, T., Sahni, N., Yi, S., Soll, D.R. (2009). CO2 regulates white-opaque

    switching in Candida albicans. Curr. Biol. 19, 330-334.

    ? Highlighted in a dispatch: Yeast mating: putting some fizz into fungal sex? Curr. Biol. 19,

    R258-60.

    6. Yi, S., Sahni, N., Daniels, K.J., Pujol, C., Srikantha, T., Soll, D.R. (2008). The same receptor, G

    protein, and mitogen-activated protein kinase pathway activate different downstream regulators

    in the alternative white and opaque pheromone responses of Candida albicans. Mol. Biol. Cell

    19, 957-970.

    ? Highlighted in “InCytes from MBC - ASCB Newsletter”. Vol. 18, #11.

    7. Srikantha, T., Daniels, K.J., Wu, W., Lockhart, S.R., Yi, S., Sahni, N., Soll, D.R. (2008). Dark

    brown is the more virulent of the switch phenotypes of Candida glabrata. Microbiology 154,

    3309-3318.

    8. Wessels, D., Srikantha, T., Yi, S., Kuhl, S., Aravind, L., Soll, D.R. (2006). The Shwachman-

    Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the

    pseudopod of Dictyostelium amoebae during chemotaxis. J.Cell Sci. 119, 370-379.

    ? Highlighted in a “Research Highlights” section in the journal Nature, 26 Jan 2006, 439,

    372-373.

    9. Srikantha, T., Borneman, A.R., Daniels, K.J., Pujol, C., Wu, W., Seringhaus, M.R., Gerstein, M.,

    Yi, S., Snyder, M., Soll, D.R. (2006). TOS9 regulates white-opaque switching in Candida

    albicans. Eukaryot. Cell 5, 1674-1687.

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     Song Yi, Ph.D. (Updated Sep., 2009)

    Research Manuscripts in Preparation:

    1. Sahni, N.*, Yi, S.*, Huang, G., Daniels, K.J., Soll, D.R. (2009). Identification of a critical

    transcription regulator in the signaling circuitry of white cell pheromone response in Candida

    albicans. *, these two authors contributed equally. In preparation for PLoS Biol.

    2. Yi, S., Sahni, N., Srikantha, T., Daniels, K.J., Soll, D.R. (2009). Phosphorylation and

    ubiquitination of Far1 plays a critical role in the regulation of opaque pheromone response in

    Candida albicans. In preparation for Mol. Biol. Cell.

    Seminar Presentations:

    1. Song Yi. A unique relationship between switching, mating and biofilm formation in the human

    pathogen Candida albicans. Special Ph.D. seminar, the University of Iowa, Iowa, 2009. 2. Song Yi. Identification and characterization of signaling circuitry for novel white pheromone

    response in the human pathogen Candida albicans. James F. Jakobsen Graduate Forum, Iowa,

    2008.

    3. Song Yi. From fungal biofilm to human tissue: a pheromone-signalling perspective. Graduate

    Student Steering Committee (GSSC) conference, the University of Iowa, Iowa, 2008.

    4. Song Yi. The alternative white and opaque responses to pheromone in the human pathogen

    rdCandida albicans. 3 Annual Biology Retreat, Davenport, Iowa, 2008.

    Poster Presentations:

    1. Song Yi, Nidhi Sahni, Karla J. Daniels, Claude Pujol, Thyagarajan Srikantha and David R. Soll.

    Pheromone responses in alternative cell types of the human pathogen Candida albicans and its

    evolutionary significance. First international conference on the evolution of sex &

    recombination by the Roy J. Carver Center for Comparative Genomics, Iowa City, Iowa, 2009. 2. Nidhi Sahni, Song Yi, Karla J. Daniels, Thyagarajan Srikantha, Claude Pujol and David R. Soll.

    A pheromone response pathway in mating-incompetent cells that facilitates mating by

    competent cells evolved from the mating pathway. First international conference on the

    evolution of sex & recombination by the Roy J. Carver Center for Comparative Genomics,

    Iowa City, Iowa, 2009.

    3. Song Yi, Nidhi Sahni, Claude Pujol, Karla J. Daniels, Thyagarajan Srikantha, Ning Ma and

    David R. Soll. A Candida albicans-specific region of the ;-pheromone receptor plays a

    selective role in the white cell pheromone response: a regulatory configuration in cellular

    rddifferentiation. 3 Annual Biology Retreat, Davenport, Iowa, 2008.

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     Song Yi, Ph.D. (Updated Sep., 2009)

    4. Song Yi, Nidhi Sahni, Thyagarajan Srikantha and David R. Soll. Identification of transcription

    regulators in the MAPK-mediated white pheromone response pathway in Candida albicans.

    thAmerican Society of Microbiology (ASM) 9 conference, New Jersey, 2008.

    5. Nidhi Sahni, Song Yi, Thyagarajan Srikantha, Karla J. Daniels and David R. Soll. The cell

    surface hydrophobicity gene CSH1 is regulated by the pheromone response pathway and plays

    a role in the unique white cell pheromone response of Candida albicans. American Society of

    thMicrobiology (ASM) 9 conference, New Jersey, 2008.

    6. Song Yi, Nidhi Sahni, Claude Pujol, Karla J. Daniels, Thyagarajan Srikantha, Ning Ma and

    David R. Soll. A Candida albicans-specific region of the intracellular loop I of the

    ;-pheromone receptor plays a role in white-specific, but not opaque-specific, pheromone thresponse. American Society of Microbiology (ASM) 9 conference, New Jersey, 2008.

    7. Guanghua Huang, Thyagarajan Srikantha, Song Yi, Nidhi Sahni, Claude Pujol, Karla J. Daniels

    and David R. Soll. A potential phosphorylation site for an A-type kinase in the Tos9p (Wor1p)

    thprotein is important for opaque cell formation. American Society of Microbiology (ASM) 9

    conference, New Jersey, 2008.

    8. Song Yi, Nidhi Sahni, Karla J. Daniels, Claude Pujol, Thyagarajan Srikantha and David R. Soll.

    Different downstream regulators of the same signal, receptor, heterotrimeric G protein and

    MAP kinase pathway elicit different pheromone responses in white and opaque Candida

    ndalbicans. 2 Annual Biology Retreat, Dubuque, Iowa, 2007.

    9. Song Yi, Wei Wu, Karla J. Daniels and David R. Soll. Candida albicans in humans: Benign

    commensal yeast becomes potential lethal pathogen. Distinguished Alumni Forum, University

    of Iowa, Iowa, 2007.

    10. Song Yi, Thyagarajan Srikantha, Deborah Wessels, Vesna Stepanovic, Jeremy Geiger and

    David R. Soll. Using Candida albicans as a model for elucidating the molecular basis of

    Shwachman- Diamond Syndrome, a human autosomal recessive disease that affects cell

    thpolarity. American Society of Microbiology (ASM) 7 conference, Texas, 2004.

    11. Song Yi. Investigating the molecular basis of the human Shwachman-Diamond Syndrome

    using a fungal model. James F. Jakobsen Graduate Forum, Iowa, 2004.

    EDITORIAL SERVICE

    2009 Reviewer for the journal Cellular Microbiology

TEACHING EXPERIENCE

    The University of Iowa, Iowa City, IA

    ? Research Mentor

    Biology Honors Student Anita Cheruvillil (Fall 2009)

    Graduate Student Jeffery Ross (Summer 2009)

    ? Instructor

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     Song Yi, Ph.D. (Updated Sep., 2009)

    Honors Primetime Workshop (143:020) (Fall 2009) ? Invited Lecturer

    Basic Biology of Human Disease (2:192) (Spring 2009) ? Teaching Assistant

    Bioinformatics (2:170) (Fall 2007)

    Cell Biology Laboratory: Bioimaging and Biotechnology (2:133) (Fall 2006)

    Principles of Biology I (2:010) (Fall 2005)

    Human Biology (2:021) (Fall 2004)

HONORS AND AWARDS

    2003-2009 Graduate Assistantship and Tuition Scholarship, the University of Iowa

    rd2008 Excellent Scientific Speaker Award, 3 Annual Biology Retreat, the University of Iowa

    nd2007 Best Poster Presentation Award, 2 Annual Biology Retreat, the University of Iowa

    2002 May Fourth” Fellowship for Academic Excellence, Peking University, China

    2002 National Honor for Outstanding Academic Achievement, Beijing, China

    2001-2003 University Tuition Scholarship, Peking University, China

MEMBERSHIP IN SCIENTIFIC SOCIETIES

    Member of the American Society for Microbiology (ASM)

SOCIAL AND ORGANIZITIONAL ACTIVITIES

    2009 Co-organizer, Raymond Fong Special Seminar (hosting renowned cancer biologist, Dr.

    Robert Weinberg), the University of Iowa

    2004-2005 Graduate Representative, Department of Biological Sciences, the University of Iowa 2004-2006 President, Chinese Students and Scholars Association (CSSA), the University of Iowa 2002 Advisor, Internet-based interactive training platform for higher education, Beijing,

    China

    2000-2001 Student Supervisor, Student Union and Service Center, Peking University, China

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     Song Yi, Ph.D. (Updated Sep., 2009)

    REFERENCES

    David R. Soll, Ph.D. Professor, Department of Biology

    The University of Iowa

    302 BBE

    Iowa City, IA 52242

    Tel.: 319-335-1111

    E-mail: david-soll@uiowa.edu

Jim Lin, Ph.D.

    Professor, Department of Biology and Program of Genetics

    The University of Iowa

    340 BBE

    Iowa City, IA 52242

    Tel.: 319-335-1075

    E-mail: jim-lin@uiowa.edu

Chun-Fang Wu, Ph.D.

    Professor, Neuroscience Program and Department of Biology

    The University of Iowa

    239 BB

    Iowa City, IA 52242

    Tel.: 319-335-1091

    E-mail: chun-fang-wu@uiowa.edu

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