Lateralized Anterior Cingulate Function during Error Processing and Conflict Monitoring as Revealed by High-Resolution fMRI
Henry Lütcke and Jens Frahm
-Institut für Biomedizinische NMR Forschungs GmbH am Max-Planck
biophysikalische Chemie, 37070 Göttingen, Germany
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Recent studies have reported that functional subdivisions ofanterior cingulate cortex (ACC) may be selectively responsiblefor conflict and error-related processing. We examined thisclaim by imaging ACC activation to correct and erroneous responseinhibitions in a Go/Nogo task. After localizing the ACC clusterin individual subjects using functional magnetic resonance imaging(fMRI) at standard resolution 3 3(2 x 2 x 4 mm), high-resolutionfMRI (1.5 x 1.5 x 1.5 mm) of the ACC was performed in a secondsession to investigate its precise functional anatomy. At standardresolution, and in agreement with previous studies, ACC wasactivated for correct and incorrect responses, albeit more sofor errors. High-resolution maps of activated ACC clusters revealedlocalized and reproducible foci in 9 out of 10 volunteers. Multisubjectanalysis suggested a bilateral distribution of error-relatedprocesses in ACC, whereas correct inhibitions only seemed toactivate ACC in the right hemisphere. Subsequent region of interestanalysis largely confirmed the activation maps. Our resultscontribute toward a better understanding of the microanatomyof ACC and demonstrate the potential of fMRI for mapping thefunctional architecture of brain regions involved in cognitivetasks at a previously unaccomplished spatial scale.
Key Words: ACC • fMRI • high resolution • lateralization
Cereb Cortex Volume: 18 Issue: 3 Pages: 508-15 Published: 2008 Mar