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The 5th International Symposium on

    Chromosomal Aberrations

    Perspectives for the 21st Century


    MMS 20th anniversary meeting

    October 26-28, 2001

Organizing Committee

    T. Ikushima K. Kondo

     (President of the conference) A. Kurishita M. Ishidate, Jr. (President Emeritus) Y. Miyamae M. Hayashi (Secretary General) T. Morita N. Asano (Treasurer) A.T. Natarajan S. Hitotsumachi G. Obe Y. Ishii T. Okigaki Y. Kikuchi T. Sofuni

Co-organized by

    Mammalian Mutagenicity Study Group/Japanese Environmental Mutagen

    Society (JEMS?MMS)

    The Society of Chromosome Research

    The Japan Radiation Research Society

    Awaji Yumebutai International Conference Center,

    Awaji Island, Hyogo, Japan

    October 26-28, 2001 at Awajishima Umebutai


October 26

16:00 Registration

17:30-20:00 5th ISCA/JEMS?MMS 20th anniversary meeting

    17:30-17:35 Welcome address by Dr. M Hayashi

    17:35-17:45 Opening remarks by Dr. M Ishidate, Jr.

    17:45-20:00 Keynote lectures Chairperson: Dr. M Ishidate, Jr

     Keynote lecture-1

    Chromosome Aberrations: Past, Present and Future

    Dr. AT Natarajan

    Leiden University Medical Centre, The Netherlands

     Keynote lecture-2

    Spontaneous and Induced Aneuploidy, Considerations

    Which May Influence Chromosome Malsegregation

    Dr. JM Parry

    Centre for Molecular Genetics and Toxicology,

    University of Wales Swansea, UK October 27

8:30-up to the end of the symposium Exhibition of posters

8:30-12:30 Session-1 Chairpersons: Drs. AT Natarajan & M Hayashi

    1-1 (8:30-9:00) 1,222344Tanabe H, Müller S, Neusser M, Habermann FA, von Hase J, Calcagno E, 2242 Solovei I, Cremer M, Cremer C, and Cremer T1Division of Genetics and Mutagenesis, National Institute of Health Sciences, Japan, 2Institute of Anthropology and Human Genetics, Ludwig Maximilians University,

    Germany, 3 Chair of Animal Breeding, Technical University of Munich, Germany,4Kirchhoff Institute of Physics, University of Heidelberg, Germany

    Radial Arrangements of Chromosome Territories in Chicken and Primate Cell

    Nuclei by Multicolor 3D-FISH: Evolutionary Considerations

    1-2 (9:00-9:30)

    Umezu K, Hirooka M, Watanabe K, Mori M, Yoshida J, Ajima J, Sakasai R and

    Maki H

    Graduate School of Biological Sciences, Nara Institute of Science and Technology,


    Spontaneous Loss of Heterozygosity (LOH) in Diploid Cells of Saccharomyces



1-3 (9:30-10:00)

    Griffin CS, Deans B, and Thacker J

    Medical Research Council, Radiation and Genome Stability Unit, Harwell, UK

    Aneuploidy, Centrosome Activity and Chromosome Instability in Cells

    Deficient in Homologous Recombination Repair

1-4 (10:00-10:30)

    Pfeiffer P, Goedecke W, and Obe G

    Dept. of Genetics, University of Essen, Germany DSB Repair and Chromosomal Aberrations

    10:30-11:00 Coffee break

1-5 (11:00-11:30) 12, and Ikushima T Ishii Y1Department of Medical Genetics, Graduate School of Medicine, Osaka University,

    Japan 2Kyoto University of Education, Kyoto, Japan

    Effects of Inhibitors of DNA Topoisomerases on the Formation of Chromatid-

    and Chromosome-type Aberrations

1-7 (11:30-12:00)

    Surrallés J, Callén E, Ramírez MJ, Creus A, and Marcos R Department of Genetics and Microbiology, Universitat Autònoma de Barcelona,


    Impaired Telomeres in the Cancer-Prone Syndrome Fanconi Anemia

    12:00-13:30 Lunch

    13:30-16:00 Session-2 Chairpersons: Drs. G Obe & T Sofuni

2-1 (13:30-14:300

    Boei JJWA, Vermeulen S, Mullenders LHF, and Natarajan AT Leiden University Medical Center, The Netherlands Complex Chromosomal Aberrations

2-2 (14:00-14:30) 1231Satoh T, Hatanaka M, Yamamoto K, Kuro-o M, and Sofuni T 1Life-science Technology Research Center, OLYMPUS Optical Co., Ltd., Tokyo, 2Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 3Department of Biofunctional Science, Faculty of Agriculture and Life Science,

    Hirosaki University, Aomori, Japan

    Application of mFISH for Analysis of Chemically induced Chromosomal

    AberrationsA Model for the Formation of Triradial Chromosomes

2-3 (14:30-15:00) 112Stack HF, Jackson MA, and Waters MD 1Alpha-Gamma Technologies, Inc., Raleigh, NC, USA. 2US EPA, Research Triangle Park, NC, USA

    Assessment of the Mutagenicity and Clastogenicity of the IARC Known and


Suspected Human Carcinogens (see abstract P-14)

2-4 (15:00-15:30)

    Cao J, Sun H, Cheng G, Zhou Z

    Third Military Medical University, P.R.of China Study on the Changes of Chromosomal Damages, Gene Mutation and DNA

    Breakages as Biological Indicators for the Nasopharynx Cancer Patients

    Receiving Radiation Therapy

2-5 (15:30-16:00) 111123, Ejima Y, Tachibana A, Yamada T, Ishizaki K, Nomura T, and Sasaki MS4Aizawa S 1Radiation Biology Center, Kyoto University, Japan; 2Aichi Cancer Center Research Institute,Japan; 3Faculty of Medicine, Osaka University,Japan; 4Kumamoto Univesity School of Medicine, Japan

    DNA Damage Response Pathway in Radioadaptive Response

    17:00-19:00 Banquet on boat

    20:00-22:00 Poster session

    October 28

    8:30-12:00 Session-3 Chairpersons: Drs. JM Parry & Y Ishii

3-1 (8:30-9:00)

    Kirsch-Volders M, Vanhauwaert A, De Boeck M, and Decordier I

    Vrije Universiteit Brussel, Belgium Importance of Detecting Aneuploidy/Polyploidy versus Chromosome


3-2 (9:00-9:30)

    Kamiguchi Y

    Asahikawa Medical College, Japan

    Radiation- and Chemical-Induced Structural Chromosomal Aberrations in

    Human Spermatozoa

3-3 (9:30-10:00)

    Adler I-D, Schmid TE, and Baumgartner A

    GSF-Institute of Experimental Genetics, Germany

    Induction of Aneuploidy in Mammalian Male Germ Cells Using the

    Sperm-FISH Assay

    10:00-10:30 Coffee break

3-4 (10:30-11:00)

    Sonta S


Institute for Developmental Research, Aichi Human Service Center, Japan

    Transmission of Structurally Abnormal Chromosomes: Meiotic Segregation

    and the Fate of Unbalanced Gametes in Mammals

3-6 (11:00-11:30) Fenech M and Crott JW

    CSIRO Health Sciences and Nutrition, Adelaide BC, SA 5000, Australia

    Folic Acid Deficiency Induces Micronuclei, Nuceloplasmic Bridges and Nuclear

    Buds in Human Lymphocytes in vitro Evidence for Breakage-Fusion-Bridge Cycle

    12:00 Closing remarks by Dr. Takaji Ikushima and adjourn


    Poster Session (October 27, 8:30 am - 28, noon)

    (Discussion: October 27, 20:00 - 22:00)


    Cheriyan VD, Kurien CJ, Ramachandran EN, Karuppasamy CV, Koya PKM, Das 1B, George KP, Rajan VK, Thampi MV, and Chauhan PS

    Cell Biology Division, Bhabha Atomic Research Centre, Mumbai-400 085 1D H S, Government of Kerala, Thiruvananthapuram 695 037, India

    The Nature and Incidence of Cytogenetically Aberrant “Rogue Cells”

    in the Lymphocytes of the Newborns

P-2 122Hoffmann GR, Littlefield LG, Sayer AM 1Department of Biology, Holy Cross College, Worcester, MA 01610, USA; 2Medical Sciences Division, Oak Ridge Institute for Science and Education, Oak Ridge,

    TN 37831, USA.

    Frequencies of X-Ray-Induced Chromosome Aberrations in Early- and Late-

    Arising Metaphases in Human Lymphocyte Cultures

P-3 111111,2Kadhim M, MacDonald D, Boulton E, Pocock D, Goodhead D and Plumb M 1MRC Radiation and Genome Stability Unit, Chilton, Didcot, OXON OX11 ORD, U.K. 2Communicating author; present address: Department of Genetics, University of

    Leicester, Leicester LE1 7RH, U.K.

    Evidence of Genetic Instability in 3Gy X-Ray-Induced Mouse Leukaemias and 3 Gy

    X-Irradiated Haemopoietic Stem Cells

P-4 111112Kodama S, Tamaki T, Yamauchi K, Urushibara A, Suzuki K, Oshimura M, 1and Watanabe M 1Laboratory of Radiation and Life Science, School of Pharmaceutical Sciences, Nagasaki

    University, Nagasaki, Japan, 2Department of Molecular and Cell Genetics, School of Life Sciences, Faculty of

    Medicine, Tottori University, Tottori, Japan

    Radiation-Induced Delayed Chromosome Aberrations Mediated by Telonomic



    Dertinger S, Huther B, Gleason S, Torous D, Hall N, and Tometsko C

    Litron Laboratories, Rochester, New York, USA

    Flow Cytometric Enumeration of Azidothymidine- and Diethylnitrosamine-

    Induced Cytogenetic Damage: An Evaluation of Murine Maternal and Fetal

    Peripheral Blood



    Corso C, Parry EM, and Parry JM

    Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, SA2 8PP. UK.

    Comparison of FISH and CGH Data in the Detection of Aneuploidy in Two Hyperploid Types of Thyroid Tumours


    Corso C and Parry JM

    Centre for Molecular Genetics and Toxicology, University of Wales Swansea, SA2 8PP.UK.

    The Rat as a Model Organism for Carcinogenicity and Mutagenicity: Development and Application of Molecular Cytogenetic Techniques for the Dissection of the Rat Genome


    Strefford C, Parry EM, and Parry JM

    Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK.

    Premature Centromere Division in p53 Modified Cell Lines


    Moore SR, Gibbons CF, Parks KK, Ritter LE, and Grosovsky AJ

    Department of Cell Biology and Neuroscience and Environmental Toxicology Graduate Program, University of California, Riverside, CA.

    Hotspots for Instability-Associated Rearrangements in Human B-Lymphoblastoid Cells

P-10 111121,3, Brassesco MS, D'Arce LPG, Mello SS, Tone LG, Passos GAS, Camparoto ML1,4and Sakamoto-Hojo ET 12Depto Genetica e Depto Pediatria e Puericultura-HC, Faculdade de Medicina de 34Ribeirão Preto-USP; Faculdade de Odontologia de Ribeirao Preto-USP; Depto

    Biologia, Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto-USP, Universidade de São Paulo, Ribeirao Preto, S.P., BRASIL

    Chromosomal Translocations in Cured ALL (Acute Lymphoblastic Leukemia) and Non-Hodgkin’s Lymphoma Patients: Evaluation of the Late Effects of Cancer



    Adekunle SSA

    Biology Department, MSC 181, P. O. Box 179, Lincoln University, PA 19352, USA Localization of Human Interstitial Telomere-Like Repeats: Comparison with Interstitial Sites of Chromosomal Breaks by Diverse Mutagens and Carcinogens


P-12 111223Urushibara A, Kodama S, Suzuki K, Kotobuki N, Oshimura M, Sonoda E, and 1 Watanabe M 1School of Pharmaceutical Sciences, Nagasaki University, Bunkyo-machi, Nagasaki, 2School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-machi, Yonago, 3Graduate School of Medicine, Kyoto University, Kyoto, Japan

    High Susceptibility to the Induction of Genetic Instability by Radiation in DNA Repair Deficient Cells


    Varzegar R, Zakeri F, Assaei R, and Heidary A

    National Radiation Protection Department (NRPD), Iranian Nuclear Regulatory Authority (INRA), Tehran, Iran, P.O. Box: 14155-4492

    Follow-Up Study of Chromosome Aberration in the Personnel of Cardiac

    Catheterization Laboratory with Chronic Low Dose X-Irradiation Exposure

P-14 112Stack HF, Jackson MA, and Waters MD 1Alpha-Gamma Technologies, Inc., Raleigh, NC, USA. 2US EPA, Research Triangle Park, NC, USA

    Assessment of the Mutagenicity and Clastogenicity of the IARC Known and

    Suspected Human Carcinogens


    Zakeri F, Varzegar R, Assai R, and Heidary A

    Radiobiology Division, National Radiation Protection Department (NRPD), Iranian Nuclear Regulatory Authority (INRA), Tehran, Iran. P.O. Box: 14155-4492

    Enhanced Frequency of Chromosomal Aberrations in Different Groups of Workers Occupationally Exposed to Radiation


    Kishi K and Sekizawa K

    Department of Cytogenetics, School of Health Sciences, Kyorin University, Hachioji, Tokyo, Japan.

    Cytogenetic Classification of DNA Damages from the Viewpoint of Induction of Chromosome Rearrangements After Inhibition of Repair Replication in G1 Phase

P-17 123Kurihara T, Inoue M, and Tatsumi K 12Division of Basic Science and Division of Core Facility, Medical Research Institute,

    Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa, 3Research Center for Radiation Safety, National Institute of Radiological Sciences, Inage, Chiba, Chiba, Japan

    Retarded Recovery of DNA Replication in Bloom's Syndrome Fibroblasts

    Following Release from Inhibition by Hydroxyurea



    Yamakage K, Kusakabe H, Wakuri S, Sasaki K, Nakagawa Y, Watanabe M, and

    Tanaka N

    Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano,

    Kanagawa 257-8523, Japan

    Relationship between in vitro Clastogenicity and Cytotoxicity Considered from 98

    Data of High Production Volume Industrial Chemicals


    Heidary A, Assaei R, Zakeri F, Varzegar R

    National Radiation Protection Department (NRPD), Iranin Nuclear Regulatory

    Authority (INRA), Atomic Energy Organization, P.O.Box 14155-4494, Tehran, IRAN

    The Interaction of Radiation and Different Anticancer Drugs in Cultured CHO

    Cells Using Cytokinesis Micronucleus Assay and Cells Survival Fraction (A

    Comparative Study)

P-20 11112, Nakano M, Itho M, Ohtaki K, Kusunoki Y, Nakamura Kodama Y12Departments of. Genetics and Radiobiology, Radiation Effects Research Foundation,

    Hiroshima, 732-0815, Japan

    Evidence for a Single Stem Cell in the Bone Marrow to Reconstitute Nearly One

    Half of the Total Lymphocyte Pool in One A-bomb Survivor




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