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RULES, REGULATIONS AND SYLLABUS FOR

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RULES, REGULATIONS AND SYLLABUS FOR

    RULES, REGULATIONS AND SYLLABUS FOR B.PHARM (FOUR YEAR INTEGRATED COURSE) DEGREE

    COURSE

    KAKATIYA UNIVERSITY, WARANGAL 506 009

    From the academic year 2000 - 2001 onwards

    (Applicable to the UCPSc and other Pharmacy colleges affiliated to KU, Warangal)

    I. GENERAL RULES AND REGULATIONS

1. Eligibility for admission

    Candidates for admission to the Degree of Bachelor of Pharmacy shall be required to have passed

    the Intermediate Examination of the Board of Intermediate Education, Andhra Pradesh or an

    Examination recognized as equivalent there to with Physics, Chemistry and Mathematics or

    biology as subjects.

    OR

    The Diploma in Pharmacy Examination from an Institute in AP recognized by the Pharmacy

    Council of India (or a local candidate with a Diploma in Pharmacy from outside AP).

    2. The degree of Bachelor of Pharmacy will be conferred on the candidates who have subsequently

    undergone the prescribed course of study of the Kakatiya University for a period of not less than

    four academic years.

    3. The course and Examination for the four year shall be designated as I-B.Pharm., II-B.Pharm., III-

    B.Pharm., and IV-B.Pharm. The examination for each year shall be on the basis of the Scheme of

    Examinations.

    4. The distribution of marks shall be as indicated in the Scheme of Examinations and the scope of

    subjects as indicated in the syllabus.

    5. In every academic year there shall be one annual examination, ordinarily in April/May and one

    supplementary examination in October/November or on such dates as may be fixed by the

    University.

    6. Candidates admitted to any year of the courses of study shall pursue in each academic year, the

    regular courses of lectures, tutorials, Practicals etc, as mentioned in the Scheme of Instructions and

    after satisfying the conditions laid down in these ordinances will be eligible to appear for the

    examinations on such dates as may be fixed by the University.

    7. A candidate to be eligible to take an examination specified in paragraph [4] shall prosecute a

    regular course of study in the courses prescribed for the examination concerned, for not less then

    one academic year in the University College of Pharmaceutical Sciences and affiliated colleges of

    Kakatiya University.

    8. A student shall be deemed to have pursued a regular course of study in a subject during each

    academic session, if he/she attended at least 75% of the classes held in each subject of

    examination and had produced a certificate of good conduct from the principal of University

    College of Pharmaceutical Sciences/other affiliated Pharmacy colleges. Provided that the Vice-

    Chancellor of the University may condone shortage in attendance not exceeding 10% in each

    subject due to one or more of the following reasons involving absence from classes.

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    a. Participation in NCC camp duly supported by a certificate to that effect from the Officer-

    Commanding, NCC.

    b. Participation in University or College team in games or cultural activities at Inter-state or

    Inter-University level duly supported by the certificate from the Office concerned;

    c. Participation in Educational excursions conducted on working days certified by the

    principal of the College. No credit will be given for excursions conducted on holidays;

    d. University deputation for young festival certified by the Principal of the College;

    e. Prolonged illness duly certified by the Medical Officer of the University Hospital or any

    Government Hospital.

9. In order to pass an examination, the candidate (i) shall obtain not less then 45 (forty five) % of the

    Marks allotted for the examination in each paper and (ii) shall obtain not less than 50 (fifty) % of

    all papers of examination for that particular year.

10. A candidate who fails in four papers or less, may be promoted to next higher class. Such candidate

    may take the examination in the papers in which he/she has failed, at the subsequent annual or

    supplementary examination.

11. The candidates of II, III and IV year B.Pharm., who failed in some of the I, II or III year papers,

    respectively may be permitted to appear for these papers at the Annual/Supplementary

    examinations together with II, III or IV year examinations provided, however, that the total

    number of papers in which they have failed is not more than four at any time for the promotion to

    next higher class.

12. The award of division shall be based on the aggregate marks obtained by a candidate in B.Pharm. I,

    II, III and IV, years examinations put together. Those who obtain 50 % marks and more but less

    than 60 % will be awarded Second Division and those who obtain 60 % and above will be

    awarded First Division. Candidates securing 75 % and the above in the aggregate of all

    examinations of B.Pharm. I, II, III and IV in first attempt shell be declared to have passed in First

    Division with Distinction. Any candidate who carries a back log at any stage, will not be eligible

    for distinction and rank.

13. A candidate shall be ranked on the basis of his/her grand total provided he/she has passed in all the

    papers of his/her I, II, III and IV year examinations in first attempt.

14. i. A Candidate who fail to secure 50 % in aggregate, but has passed in all papers shall be allowed

    to appear at a supplementary examination in any theory papers of his/her choice of that particular

    year.

    ii. A Candidate who fails to secure 50 % in aggregate and also fails in not more than one paper

    shall be allowed to appear at a supplementary examination in the paper failed and two theory

    papers of his/her choice.

15. The college, if possible will organize an educational and Industrial tours for 15 days during III

    year B.Pharm. Students as a part of the teaching program, may take part accompanied by faculty

    members deputed by the college.

16. Industrial/Hospital training: It is compulsory that every student of B.Pharm shall undergo training

    for a period of 6 weeks during final B.Pharm (in summer vacation) in Pharmaceutical Company or

    in a Hospital.

    .

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    SCHEME OF INSTRUCTIONS AND EXAMINATIONS

B.PHARM I YEAR

    ========================================================================= Sl.No. Subjects Hours\Week Sessional Annual Total Exam

     Marks Marks Marks duration(hrs)

    ========================================================================= THEORY PAPERS:

01) Dispensing & General Pharmacy 3 20 80 100 3

    02) Pharmaceutical Inorganic Chem. 2 20 80 100 3

    03) Analytical Chemistry 2 20 80 100 3

    04) Pharmaceutical Organic Chem. - I 4 20 80 100 3

    05) Biostatistics & Comp. Applications 3 20 80 100 3

    06) Remedial Mathematics\Biology 2 20\10 80\40 100\50 3/1.5 07) Pharmacognosy - I 2 10 40 50 1.5

     ----------------------------------------------------------------

     Total 18 130\120 520\480 650\600

     ----------------------------------------------------------------

PRACTICAL PAPERS:

01) Dispensing & General Pharmacy 3 20 80 100 3

    02) Pharm.Inorganic & Anal.Chemistry 3 20 80 100 3

    03) Pharm.Organic Chemistry-I & II 3 20 80 100 3

    04) Remedial Biology 3 10 40 50 2

    05) Biostatistics & Comp. Applications 3 20 80 100 3

     --------------------------------------------------------

     Total 15 80\90 400\440 400\450

     --------------------------------------------------------

     3

B.PHARM II YEAR

THEORY PAPERS:

    ===================================================================== Sl.No. Subjects Hours Sessional Annual Total Duration of

     \Week Marks Marks Marks Examination (hrs) ===================================================================== 01) Pharm. Jurisprudence 2 20 80 100 3 02) Pharm. Engineering 3 20 80 100 3 03) Pharm.Org. Chemistry-II 3 20 80 100 3 04) Pharm.Micr & Immunol. 3 20 80 100 3 05) Human Physiology 3 20 80 100 3

    06) Bio-Chemistry 2 20 80 100 3

    07) Pharmaceutical 2 20 80 100 3

     Administration

     --------------------------------------------------------------

     Total 18 140 560 700

     --------------------------------------------------------------

PRACTICAL PAPERS:

01) Pharm.Engineering 3 20 80 100 6

    02) Pharm.Org Chemistry -II 3 20 80 100 6

    03) Pharm.Micr & Immunol. 3+1 20 80 100 6

    04) Human Physiology 3 20 80 100 6

    05) Bio-Chemistry 3 20 80 100 6

     -------------------------------------------------------------

     Total 18+1 120 480 600

     -------------------------------------------------------------

     4

B.PHARM III YEAR

    ===================================================================== Sl.No. Subjects Hours\Week Sessional Annual Total Duration of

     Marks Marks Marks Examination (hrs)

    ===================================================================== THEORY PAPERS:

01) Cosmetic Technology 2 20 80 100 3

    02) Pharmaceutical Analysis 3 20 80 100 3

    03) Medicinal Chemistry 3 20 80 100 3

     (Natural Prod.)

    04) Pharmacognosy - II 3 20 80 100 3

    05) Pharmacology - I 3 20 80 100 3

    06) Physical Pharmacy 3 20 80 100 3

     -------------------------------------------------------------

     Total 18 120 480 600

     -------------------------------------------------------------

PRACTICAL PAPERS:

01) Cosmetic Technology 3 20 80 100 6

    02) Pharmaceutical Analysis 3 20 80 100 6

    03) Medicinal Chemistry-I(Nat. Prod.) 3 20 80 100 6 04) Pharmacognosy - II 3 20 80 100 6

    05) Pharmacology - I 3 20 80 100 6

    06) Physical Pharmacy 3 20 80 100 6

     --------------------------------------------------------------

     Total 18 120 480 600

     --------------------------------------------------------------

     5

B.PHARM IV YEAR

    ========================================================================= Sl.No. Subjects Hours\Week Sessional Annual Total Duration of

     Marks Marks Marks Examination (hrs)

    =========================================================================

THEORY PAPERS:

01) Pharm. Technology 3 20 80 100 3

    02) Pharm. Biotechnology 3 20 80 100 3

    03) Bio-Pharmaceutics & 2 20 80 100 3

     Pharmacokinetics

    04) Medicinal Chemistry-II 3 20 80 100 3

     (Synthetic)

    05) Pharmacognosy - III 3 20 80 100 3

    06) Pharmacology - II 3 20 80 100 3

    07) Hospital & 2 20 80 100 3

     Clinical Pharmacy

     -------------------------------------------------------------

     Total 19 140 560 700

     -------------------------------------------------------------

PRACTICAL PAPERS:

01) Pharm.Technology 3 20 80 100 6

    02) Pharm.Biotechnology 3+1 20 80 100 6

    02) Bio-pharmaceutics &

    Pharmacokinetics 3 20 80 100 6

    03) Medicinal Chemistry-II 3 20 80 100 6

     (Synthetic)

    04) Pharmacognosy III 3 20 80 100 6

    05) Pharmacology - II 3 20 80 100 6

    06) Project Work 3 20 80 100 6

     ----------------------------------------------------------------------

     Total 18+1=19 120 480 600

     ----------------------------------------------------------------------

     6

    B.PHARM - FIRST YEAR

I.T.1. DISPENSING AND GENERAL PHARMACY

    (Theory)[3hrs/Week]

    1.History of Pharmacy; Development of Pharmacy Education, Industries and Research.

    a) Pharmacy literature: History of I.P., B.P., lU.S.P., B.P.C, and N.F. of India and

    Extra Pharmacopoeia.

     b) Pharmacy Ethics: Introduction to code of Ethics of Pharmacy.

2.Galenicals: Methods of preparation, storage and packing. Of Infusions, Decoctions,

    Tinctures, Liquid extracts, Dry extracts, Study in detail of extraction processes, like

    Maceration and Percolation.

3.Principles and various methods involved in the preparation of the following:

    Solutions, Aromatic waters, Syrups, Mucilages, Spirits, Elixirs, Magmas and Glycerines.

4. Pharmaceutical calculations (only in C.G.S system): Percentage calculations,

    Proportional calculations, allegation, Isotonic solutions, Proof spirits and Displacement

    values.

    5. Principles of dispensing: The form of prescription Handling, Pricing and Refilling of prescription, Prescription containers, Labelling and Packing.

6. Posology: Calculation of doses and a general know-how of the doses.

7. Principles involved and procedures adopted in the dispensing of the following

    classes of Pharmaceutical preparations: Mixtures, Emulsions, Powders, Lotions,

    Liniments, Ointments, Creams, Pastes and jellies, Suppositories, Pessaries, Nasal bougies,

    Inhalations, Eye drops, Ear drops, Throat paints and Gargles.

    8. Incompatibnility: Scope, Classes of incompatibility, Correction of incompatibilities, Handling of incompatible prescriptions pertaining to: alkaloidal incompatibility,

    Incompatibility of soluble iodides, soluble salicylates and benzoates with acids, ferric

    salts and alkaline substances, incompatibility causing evalution of carbondioxide of

    soluble barbiturates and emulsifying agents.

I.P.1. DISPENSING AND GENERAL PHARMACY

    (Practicals) [3hrs/week]

    1. Preparation involving Pharmaceutical calculations.

    2. Preparation of galenicals-Tinctures, Liquid extracts.

    3. Preperation of some solutions, Aromatic waters, syrups, Mucilayes, Elixirs,

    glycerines, Magmas.

    4. Dispensing of Mixtures, Emulsions, Lotoions, Liniments, Ointments, Creams,

    Pastes, Jellies, Suppositories, Ear drops, gargles and throat paints.

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5. Incompatible mixtures and their handling.

    I.T.2. PHARMACEUTICAL INORGANIC CHEMISTRY

    (Theory) [2hrs/week]

    A systematic study of the following pharmaceutical inorganic compounds with reference to their

    preparations, properties, tests for identity and purity, pharmaceutical uses and assay methods as given in

    Indian Pharmacopiea (IP).

    1. Group IA- Sodium and Potassium Compounds: Sodium acid citrate, Lithium carbonate, sodium

    benzoate, sodium borate, sodium citrate, sodium chloride, sodium hydrogen sulphide, sodium

    metabisulphate, sodium lauryl sulphate, sodium phosphate, sodium hydrogen phosphate, sodium borate,

    sodium potassium tartrate, potassium permanganate, potassium dichromate, potassium chloride,

    potassium bromide and potassium iodide.

    Group-I B-copper, silver and gold compounds: Copper sulphate, silver nitrate, strong silver

    proteins, mild silver proteins, oligodynamic properties of copper and silver.

    2. Group-IIA- Magnesium, Calcium and Barium Compounds: Light and heavy magnesium oxide,

    magnesium hydroxide, magnesium sulphate, magnesium trisilicate, magnesium strearate, calcium

    gluconate, calcium acetate, calcium pantothenate and barium sulphate.

    Group-II B- Zinc and Mercury Compounds: Zinc oxide, zinc sulphate, zinc stearete, zinc

    undecylenate, mercury, mercury with chalk, yellow mercuric oxide, mercurous chloride and

    ammoniated mercury.

    3. Group IIIA and IIIB - Boron and Aluminium Compounds: Boric acid, aluminium hydroxide gel,

    aluminium magnesium trisilicate, alum.

4. Group IVA and IVB Compounds: Bentonite, light and heavy kaolins and kaolin poultice.

5. Group VA and VB, Nitrogen, Antimony, and Bismuth Compounds: Strong and diluted ammonia

    solutions, strong ammonium acetate solutions, aromatic spirit of ammonia, ammonium chloride,

    antimony sodium tartrate, sodium antimony gluconate, bismuth subcarbonate.

    6. Group VIB- Sulphur, Selenium Compounds: Sublimated sulphur, precipitated sulphur and selenium

    sulphide.

7. Group VIIA and VIIB- Hydrogen, Oxygen and Halogen Compounds: Purified water, water for

    injection, hydrogen peroxide, chlorinated lime, aqueous iodine solution and strong iodine solution.

8. Group VIII-Iron Compounds: Ferrous sulphate, ferrous gluconate, ferric ammonium citrate, iron

    and quinine citrate.

9. The occurrence of impurities in pharmaceutical preparations: Types of impurities and limit test for

    chlorides, sulphate, arsenate, lead and iron.

I.T.3. PHARMACEUTICAL ANALYTICAL CHEMISTRY:

    (Theory) [2Hrs/Week]

1. Balances etc.: Different types of balances and weighing. Types of analyses, obtaining samples,

    measurement of sample and types of pipettes.

    2. Computation of Analytical Results: Significant numbers, sources of errors and their rectification,

    statistical traentment of data and rejection of data.

3. Ionic Equations of solutions-Stoichiometry and Analytical Problems: Determination of noramality,

    Percentage purity, Molarity, Molality and their interconversions.

     8

4. Principles of Volumetrric and Gravimetric Analyses: Standardization, use of primary and

    secondary standards, Acid-base concepts, common ion effect and solubility product, PH and Buffers.

    5. General principles and theory of: acidimetry, alkalimetry, oxidation-reduction methods, precipitation

    methods. An account of indicators used in these titrations.

    6. Complexometric Titrations: Theory, types and applications in pharmaceutical analysis. Masking and

    Demasking and its applications.

    7. Non-aqueous Titrations: Theory, types of solvents used, and applications in pharmaceutical analysis.

Application of the above methods in the analysis of drugs official in IP 1996.

I.P.2. PHARMACEUTICAL INORGANIC AND ANALYTICAL CHEMISTRY

    (Practicals) [3Hrs/Week]

Detection and assay of some pharmaceutical inorganic substances

    Limit tests and tests for purity

    I.T.4. PHARMACEUTICAL ORGANIC CHEMISTRY - I

    (Theory)[4hrs/Week]

1.Structure and Activity of Organic Molecules: Shapes of Organic molecules, Bond

    lengths, Bond angles and Bond dissociation energies. Electronic effects in Organic

    Molecules: Inductive effect, Electromeric or Mesomeric Effect, Hyperconjugation,

    concept of resonance, Types of organic reagents and reactions.

2. A Study of Hydrocarbons:

    (A) Aliphatic/Alicyclic Hydrocarbons: Nomenclature, Isomerism (Chain,

    conformational and geometrical) Relative stabilities (Heats of Combustion and

    Hydrogenation), Ring stabilities of cyclohexane, chair-boat Conformation, Bayer's strain

    theory and Sachse-Mohr theory. Characteristic properties of hydrocarbons: Free radical

    substitution reactions (Halogenation) of Alkanes, Selectivity of Halogen, Electrophilic

    addition reactions of alkenes, Markovnikov's Rule, Kharasch effect, Bayer's Oxidation

    (Cis-hydroxylation, Polymerisation. Alkadienes : 1,4 addition reactions. Acidity of 1-

    alkynes, Formation of Metal acetylides. Stereospecific reduction of alkynes. Addition of

    hydrogen halide (HCI) addition of water and keto-enol tautomerism.

    (B)Aromatic Hydrocarbons:

    Kekule's structure of Benzene, Bond lengths,Heats of hydrogenation and stability,

    Molecular orbital picture of Benzene, Aromaticity, Huckel’s rule, Nomenclalture of Benzene derivatives, characteristic reactions of Benzene, theory of reactivity and

    orientation in monosubstituted benzenes.

    Polynuclear aromatic hydrocarbons: Nomenclature, structure and aromatic character of

    Napththalene and Anthracene. Resonance structures, Electron density and reactivity.

    Electrophilic substitution, Oxidation and reduction reactions.

3. Halogen Compounds:

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(A) Aliphatic: Nomenclature, positional and Conformational isomerism, two major

    methods of preparation, Characteristic Nucleophilic substitution reactions, SN1 and SN2,

    Walden inversion, Elimination reaction, and saytzef’s rule Factors that play role.

    (B) Aromatic: Nomenclaturte, Low reactivity of halobenzenes towards nucleophilic

    substitution, Benzyne ion concept.

4. Hydroxy Compounds and Ethers:

    (A) Alcohols: Nomenclature, classification, Two important methods of preparation,

    physical properties, Hydrogen bonding, characteristic Nucleophilic substitution, reactions

    (Replacement of -OH by -Cl), Elimination reactions Reimer Tiemann reaction and ooo , 2 and 3 alcohols. Relative reactivities of 1

    (B) Phenols: Nomenclature, Two important methods of preparation, Physical properties,

    Acidity of Phenols, Stability of phenoxide ion, Reactions of Phenols, Kolbe-Schmidt

    reaction stability of conjugated dienes, and Fries rearrangement.

    (C) Ethers: Nomenclature, Williamson's synthesis, Action of HI on ethers(Ziesel’s

    method).

    5. Carbonyl Compounds: Nomenclature, Two important methods of preparation, polarity of carbonyl group, Relative reactivities of carbonyl Compounds, Nucleophilic

    addition and Addition-Elimination reactions, Oxidation-Reduction reactions, Aldol

    condensation, Cannizzaro reaction, Benzoin Condensation, Perkins reaction,

    Reformatsky reaction.

6. Carboxylic acids and their derivatives:

    (A) Carboxylic acids: Nomenclature, Inter molecular association, stability of carboxylate anion, Two important methods of preparation, Decarboxylation, functional groups

    Reactions, Reduction of Carboxylic acids. A note on dicarboxylic acids.

    (B) Acid derivatives: (Acid Chlorides, anhydrides, esters and amides). Nomenclature, Reactions like hydrolysis, Reduction of estersand amides, Hofmann's degradation of

    amides. Brief account of Malonic and acetoacetic esters. Their importance in synthesis.

7. Nitrogen Compounds:

    (A) Amines: Nomenclature, Basicity of amines, Classification, Relative reactivity,

    Hinsberg method of separation, Acylation reactions, Diazotisation and Reactions of

    Diazonium salts.

I.P.3. PHARMACEUTICAL ORGANIC CHEMISTRY - I

    (Practicals)[3 hrs/Week]

    A. Organic Preparations: Iodoform, nitrobenzene, n-butyl acetate,

    sulphanilamide, B-naphthyl methyl ether, benzoic acid, aspirin, acetanilide

    and p-bromoacetanilide.

    B. Identification of Mono-functional Organic Compounds: by studying their

    physical properties, detection of extra elements, characteristic functional

    group reactions and preparation of one of the rational derivatives. The

    following types of compounds are included for the study: Acids, phenols,

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