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AGPCP363

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AGPCP363

    AGP:CP/363, 1998

    FIPRONIL

    ()-5-amino-1-(2,6-dichloro-,,-trifluoro-p-tolyl)-4-trifluoromethylsulphinylpyrazole-3-

    carbonitrile

    INFORMATION

COMMON NAME: fipronil (ISO)

STRUCTURAL FORMULA:

    N Cl

    N

    N CF3 CF3 S

    ClNHO 2

EMPIRICAL FORMULA: C H Cl F N O S 12 4264

RMM: 437.1

CAS REGISTRY NUMBER: 120068-37-3

CIPAC CODE NUMBER: 581

CHEMICAL NAMES: ()-5-amino-1-(2,6-dichloro-,,-trifluoro-p-tolyl)-

    4-trifluoromethylsulphinylpyrazole-3-carbonitrile

    (IUPAC).

     5-amino-;2,6-dichloro-4-(trifluoromethyl)phenyl-4-

    (1R,S)-(trifluoromethyl)sulfinyl-1H-pyrazole-3-

    carbonitrile (CA).

    FIPRONIL TECHNICAL

    FAO Specification 581/TC/S/F (1998)

.1 DESCRIPTION

    The material shall consist of fipronil together with related manufacturing impurities and

    shall be a white to yellowish crystalline powder free from visible extraneous matter and

    added modifying agents. It is usually manufactured as a wet material to reduce its dustiness

    and the resulting risk of inhalation.

.2 ACTIVE INGREDIENT

.2.1 Identity tests (581/TC/M2, CIPAC J, p. 60)

    An identity test is required if the identity of the active ingredient is in doubt (e.g.

    chromatographic retention time under analytical conditions of the method of analysis or IR

    spectrum).

.2.2 Fipronil (581/TC/M3, CIPAC I J, p. 60)

    The fipronil content shall be declared (not less than 950 g/kg on the dry weight basis) and,

    when determined, the content obtained shall not differ from that declared by more than

    ? 25 g/kg.

.3 IMPURITIES

.3.1 Water (MT 30.5, CIPAC J, p. 60)

    For the wet material : 60 to 90 g/kg

.4 PHYSICAL PROPERTIES

.4.1. Melting point (MT 2, CIPAC F, p.5)

    Range after drying at 100?C for 4 hours : 194?C to 203 ?C (Note 1)

.4.2. pH range (MT 75 adapted, CIPAC F, p.205)

    pH range of a 1 % dispersion in a water + acetonitrile 98/2 vol./vol. mixture : 5.0 to

    7.0

NOTES

    1 This range covers the melting temperatures of the two crystalline forms possibly present in

    the technical material.

    FIPRONIL

    ULTRA LOW VOLUME LIQUIDS

    FAO Specification 581/UL/S/F (1998)

.1 DESCRIPTION

    The material shall consist of fipronil, complying with the requirements of FAO specification

    581/TC/S/F (1998), in the form of an organic solution, together with related manufacturing

    impurities and any necessary formulants. It shall be in the form of a stable liquid, free from

    visible suspended matter and sediment.

.2 ACTIVE INGREDIENT

.2.1 Identity tests (581/UL/M2, CIPAC J, p. 63)

    An identity test is required if the identity of the active ingredient is in doubt (e.g.

    chromatographic retention time under analytical conditions described in the method of

    analysis or IR pectrum.

.2.2 Fipronil (581/UL/M3, CIPAC J, p. 63)

    The fipronil content shall be declared (g/kg or g/l) and, when determined, the content

    obtained shall not differ from that declared by more than the following amounts :

    Declared content Permitted tolerance

    Up to 25 g/kg or g/l ? 15 % of the declared content

    Above 25 up to 100 g/kg or g/l ? 10 % of the declared content

.3 IMPURITIES

.3.1 Water (MT 30.5, CIPAC J, p. 63)

    Maximum : 2 g/l

.4 PHYSICAL PROPERTIES

.4.1 Mass per millilitre at 20?C (MT 3.3, CIPAC F, p.18)

    If required, the range of the mass per millilitre at 20 ? 2?C (g/ml) shall be declared.

.4.2 pH range (MT 75.2, CIPAC F, p.206)

    pH range : 6.0 to 8.0

.4.3 Flash point (MT 12.2, CIPAC F, p.37)

    Minimum : 61 ?C

.4.4 Kinematic viscosity (MT 22.1, CIPAC F, p.75)

    The respective viscosity range at 20 2?C shall be declared for individual formulations.

    Maximum : 50 Centistokes

    .4.5 Volatility (Method under consideration)

    The respective non volatile residue at 20 2?C (Note 1) shall be declared for individual

    formulations and the testing method provided.

.5 STORAGE STABILITY

.5.1 Stability at 0?C (MT 39.1, CIPAC F, p.128)

    After storage at 0 1?C for 7 days, the volume of solid and / or liquid which separates shall

    not be more than 0.3 ml.

.5.1 Stability at 54?C (MT 46.1.1, CIPAC F, p.149) (Note 4)

    After storage at 54 + 2?C for 14 days, the determined average active ingredient content

    must not be lower than 95 % relative to the determined average content found before

    storage and the product shall continue to comply with .4.2 and .4.4.

NOTES

1. Unless another temperature is specified.

    2. Analysis of the product before and after storage should be carried out at the same time

    (i.e. after storage) to reduce the analytical error.

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